PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state

Autor: Mair, Iris, Besusso, Dario, Saul, Louise, Patel, Sarju D, Ravindran, Rahul, McPherson, Rhoanne C, Leech, Melanie D, O'Connor, Richard A, Anderton, Stephen M, Mellanby, Richard J

Publikováno v: Mair, I, Besusso, D, Saul, L, Patel, S D, Ravindran, R, McPherson, R C, Leech, M D, O'Connor, R A, Anderton, S M & Mellanby, R J 2019, ' PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state ', European Journal of Immunology, vol. 49, no. 1, pp. 112-120 . https://doi.org/10.1002/eji.201847868

T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell population can respond effectively to pathogens but remains tolerant to self-antigens. We probed the mechanisms of T cell adaptation using an experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::65a29494fc4458f435ed257809e220d1
https://hdl.handle.net/20.500.11820/2f4a1c10-b517-47f3-877b-d9bb7b317f86

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Autor: Colbeck, Emily J, Hindley, James P, Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C, Turner, Darryl G, Ladell, Kristin, Price, David A, O'Connor, Richard A, Anderton, Stephen M, Godkin, Andrew J, Gallimore, Awen M

Publikováno v: Colbeck, E J, Hindley, J P, Smart, K, Jones, E, Bloom, A, Bridgeman, H, McPherson, R C, Turner, D G, Ladell, K, Price, D A, O'Connor, R A, Anderton, S M, Godkin, A J & Gallimore, A M 2015, ' Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors ', Oncotarget, vol. 6, no. 28, pp. 24649-59 . https://doi.org/10.18632/oncotarget.5584

Foxp3+ regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6610019ae46174a00831709867bcd476

Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells

Autor: Reynolds, Ben C., Turner, Darryl G., McPherson, Rhoanne C., Prendergast, Catriona T., Phelps, Richard G., Turner, Neil A., O'Connor, Richard A., Anderton, Stephen M.

Publikováno v: Reynolds, B C, Turner, D G, McPherson, R C, Prendergast, C T, Phelps, R G, Turner, N A, O'Connor, R A & Anderton, S M 2014, ' Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells ', European Journal of Immunology, vol. 44, no. 11, pp. 3342–3352 . https://doi.org/10.1002/eji.201444687

Interest in manipulating the immunosuppressive powers of Foxp3-expressing T regulatory (Treg) cells as an immunotherapy has been tempered by their reported ability to produce pro-inflammatory cytokines when manipulated in vitro, or in vivo. Understan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ed4b2d5f940c6ab6c696f4b4feaa7b1f
https://eprints.gla.ac.uk/109287/1/109287.pdf

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Induction of Passive EAE Using Myelin-Reactive CD4+ T Cells.

Autor: McPherson, Rhoanne C., Cambrook, Helen E., O'Connor, Richard A., Anderton, Stephen M.

Publikováno v: T-Helper Cells; 2014, p187-198, 12p