Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

Autor: Smith, SA, Sessions, RB, Shoemark, DK, Williams, C, Ebrahimighaei, R, McNeill, MC, Crump, MP, McKay, TR, Harris, G, Newby, AC, Bond, M

Publikováno v: Smith, S A, Sessions, R B, Shoemark, D K, Williams, C, Ebrahimighaei, R, McNeill, M C, Crump, M P, McKay, T R, Harris, G, Newby, A C & Bond, M 2019, ' Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking ', Journal of Medicinal Chemistry, vol. 62, no. 3, pp. 1291-1305 . https://doi.org/10.1021/acs.jmedchem.8b01402

© Copyright 2019 American Chemical Society. The Hippo pathway is an important regulator of cell growth, proliferation, and migration. TEAD transcription factors, which lie at the core of the Hippo pathway, are essential for regulation of organ growt

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Substrate stiffness promotes vascular smooth muscle cell calcification by reducing the levels of nuclear actin monomers.

Autor: McNeill MC; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Li Mow Chee F; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Ebrahimighaei R; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Sala-Newby GB; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Newby AC; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Hathway T; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Annaiah AS; Bristol Heart Institute, University Hospital, Bristol NHS Foundation Trust, Bristol BS2 8HW, United Kingdom., Joseph S; Bristol Heart Institute, University Hospital, Bristol NHS Foundation Trust, Bristol BS2 8HW, United Kingdom., Carrabba M; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom., Bond M; Department of Translational Health Sciences, Bristol Medical School, Bristol BS2 8HW, United Kingdom. Electronic address: Mark.bond@bris.ac.uk.

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Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation.

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Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD.

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