Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.

Autor: Chen Z; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, 37232, TN, USA., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Law PJ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Fernandez-Rozadilla C; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.; Genomic Medicine Group, Instituto de Investigacion Sanitaria de Santiago, Santiago de Compostela, Spain., Ping J; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Jia G; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Li C; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Shen Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Xie Y; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Timofeeva MN; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark., Thomas M; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Schmit SL; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, OH, USA., Díez-Obrero V; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Devall M; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Moratalla-Navarro F; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Fernandez-Tajes J; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Palles C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Sherwood K; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Briggs SEW; Department of Public Health, Richard Doll Building, University of Oxford, Oxford, UK., Svinti V; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Donnelly K; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Farrington SM; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Blackmur J; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vaughan-Shaw PG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Lu Y; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Broderick P; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Studd J; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Conti DV; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Schumacher FR; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Melas M; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Rennert G; Clalit National Cancer Control Center, Haifa, Israel.; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Obón-Santacana M; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Martín-Sánchez V; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Biomedicine Institute, University of León, León, Spain., Oh JH; Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea., Kim J; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea., Jee SH; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Jung KJ; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea., Kweon SS; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea., Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea., Shin A; Cancer Research Institute, Seoul National University, Seoul, South Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea., Ahn YO; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea., Kim DH; Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea., Oze I; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Matsuo K; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Tanikawa C; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Ren Z; School of Public Health, Sun Yat-sen University, Guangzhou, China., Gao YT; State Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Jia WH; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Win AK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Pai RK; Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA., Figueiredo JC; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Haile RW; Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, Los Angeles, CA, USA., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada., Woods MO; Division of Biomedical Sciences, Memorial University of Newfoundland, St. John, ON, Canada., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; School of Public Health, University of Washington, Seattle, WA, USA., Duggan D; City of Hope National Medical Center, Translational Genomics Research Institute, Phoenix, AZ, USA., Cheadle JP; Institute of Medical Genetics, Cardiff University, Cardiff, UK., Kaplan R; MRC Clinical Trials Unit, Medical Research Council, Cardiff, UK., Kerr R; Department of Oncology, University of Oxford, Oxford, UK., Kerr D; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Kirac I; Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia., Böhm J; Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland., Mecklin JP; Central Finland Health Care District, Jyväskylä, Finland., Jousilahti P; Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Knekt P; Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Aaltonen LA; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Rissanen H; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Pukkala E; Faculty of Social Sciences, Tampere University, Tampere, Finland.; Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland., Eriksson JG; Folkhälsan Research Centre, University of Helsinki, Helsinki, Finland.; Human Potential Translational Research Programme, National University of Singapore, Singapore, Singapore.; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Cajuso T; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Hänninen U; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Kondelin J; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Palin K; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Tanskanen T; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Renkonen-Sinisalo L; Department of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland., Männistö S; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Weinstein SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ruiz-Narvaez E; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer JR; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Slone Epidemiology Center at Boston University, Boston, MA, USA., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia., Platz EA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Visvanathan K; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Ulrich CM; Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA., Siegel E; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Brezina S; Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria., Gsur A; Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria., Campbell PT; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany.; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany., Slattery ML; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Potter JD; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand., Tsilidis KK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France., Murphy N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France., Castells A; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain., Castellví-Bel S; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain., Moreira L; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain., Arndt V; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., Shcherbina A; Department of Genetics, Stanford University, Stanford, CA, USA., Bishop DT; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Southey MC; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia., Idos GE; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., McDonnell KJ; Clalit National Cancer Control Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., Abu-Ful Z; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel., Greenson JK; Clalit National Cancer Control Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Shulman K; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel., Lejbkowicz F; Clalit National Cancer Control Center, Haifa, Israel.; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.; Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel., Offit K; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Su YR; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Steinfelder R; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Keku TO; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA., van Guelpen B; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Hudson TJ; Ontario Institute for Cancer Research, Toronto, ON, Canada., Hampel H; Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Pearlman R; Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hayes RB; Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA., Martinez ME; Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.; Population Sciences, Disparities and Community Engagement, University of California San Diego Moores Cancer Center, La Jolla, CA, USA., Thomas SS; Fred Hutchinson Cancer Center, Seattle, WA, USA., Pharoah PDP; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Larsson SC; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Yen Y; Taipei Medical University, Taipei, Taiwan., Lenz HJ; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., White E; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA., Li L; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Doheny KF; Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Pugh E; Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Shelford T; Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chan AT; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Cruz-Correa M; Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico., Lindblom A; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Hunter DJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Joshi AD; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Schafmayer C; Department of General Surgery, University Hospital Rostock, Rostock, Germany., Scacheri PC; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Kundaje A; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Schoen RE; Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Hampe J; Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Stadler ZK; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic., Vodickova L; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic., Vymetalkova V; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic., Edlund CK; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gauderman WJ; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shibata D; Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA., Toland A; Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA., Markowitz S; Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA., Kim A; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., van Duijnhoven F; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands., Feskens EJM; Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands., Sakoda LC; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Gago-Dominguez M; Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Wolk A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Pardini B; Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy.; Italian Institute for Genomic Medicine, Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy., FitzGerald LM; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Lee SC; National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Ogino S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Bien SA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Li CI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Lin Y; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Prentice R; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bézieau S; Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France., Yamaji T; Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Sawada N; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Iwasaki M; Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Le Marchand L; Cancer Center, University of Hawaii, Honolulu, HI, USA., Wu AH; Preventative Medicine, University of Southern California, Los Angeles, CA, USA., Qu C; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., McNeil CE; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Coetzee G; Van Andel Research Institute, Grand Rapids, MI, USA., Hayward C; MRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Deary IJ; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Harris SE; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Theodoratou E; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Reid S; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Walker M; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Ooi LY; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore., Lau KS; Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Zhao H; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Dunlop MG; Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Gruber SB; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA., Houlston RS; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Moreno V; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain., Casey G; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Tomlinson I; Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 26; Vol. 15 (1), pp. 3557. Date of Electronic Publication: 2024 Apr 26.

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.

Autor: Bien SA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. sbien@fredhutch.org.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. sbien@fredhutch.org., Su YR; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Conti DV; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Harrison TA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Qu C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Guo X; Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Lu Y; Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Auer PL; Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53205, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Banbury BL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Bézieau S; Centre Hospitalier Universitaire Hotel-Dieu, 44093, Nantes, France.; Service de Génétique Médiczle, Centre Hospitalier Universitaire (CHU), 44093, Nantes, France.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120, Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Buchanan DD; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.; Colorectal Oncogenomics Group, Department of Pathology, University of Melbourne, Melbourne, VIC, 3010, Australia.; Genetic Medicine and Familial Cancer Centre, The Royal Melbourne Hospital, Parkville, VIC, 3010, Australia.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Caan BJ; Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA, 94612, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Campbell PT; Epidemiology Research Program, American Cancer Society, Atlanta, GA, 30329-4251, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Carlson CS; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Chan AT; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Chang-Claude J; Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Genetic Tumour Epidemiology Group, University Medical Center Hamburg-Eppendorf, University Cancer Center Hamburg, 20246, Hamburg, Germany.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Chen S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Connolly CM; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Easton DF; Department of Public Health and Primary Care School of Clinical Medicine, University of Cambridge, Cambridge, England, 01223, UK.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Feskens EJM; Division of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, 1X5, Canada.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.; Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, 3004, Australia.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Gunter MJ; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Hampe J; Medical Department 1, University Hospital Dresden, TU Dresden, 01307, Dresden, Germany.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Huyghe JR; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Hudson TJ; Ontario Institute for Cancer Research, Toronto, ON, Canada.; AbbVie Inc, 1500 Seaport Blvd, Redwood City, CA, 94063, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Jacobs EJ; Epidemiology Research Program, American Cancer Society, Atlanta, GA, 30329-4251, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Kampman E; Division of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Kang HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Kühn T; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Küry S; Centre Hospitalier Universitaire Hotel-Dieu, 44093, Nantes, France.; Service de Génétique Médiczle, Centre Hospitalier Universitaire (CHU), 44093, Nantes, France.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Lejbkowicz F; Clalit Health Services National Israeli Cancer Control Center, 34361, Haifa, Israel.; Department of Community Medicine and Epidemiology, Carmel Medical Center, 34361, Haifa, Israel.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Le Marchand L; University of Hawai'i Cancer Center, Honolulu, Hawaii, 96813, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Milne RL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.; Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, 3004, Australia.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Li L; Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH, 44106, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Li CI; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Lindblom A; Department of Clinical Genetics, Karolinska University Hospital Solna, 171 77, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet Solna, 171 77, Stockholm, Sweden.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Lindor NM; Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Martín V; Biomedicine Institute (IBIOMED), University of León, León, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., McNeil CE; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Melas M; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Moreno V; CIBER Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08028, Barcelona, Spain.; University of Barcelona, 08007, Barcelona, Spain.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Newcomb PA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Offit K; Department of Medicine, Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Pharaoh PDP; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB2 1TN, UK.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Potter JD; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Qu C; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Riboli E; School of Public Health, Imperial College London, London, UK.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Rennert G; Clalit Health Services National Israeli Cancer Control Center, 34361, Haifa, Israel.; Department of Community Medicine and Epidemiology, Carmel Medical Center, 34361, Haifa, Israel.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Sala N; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Molecular Epidemiology Group, Translational Research Laboratory, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Schafmayer C; Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24118, Kiel, Germany.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Scacheri PC; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Schmit SL; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa, FL, 33612, USA.; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa, FL, 33612, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Severi G; Centre for Research in Epidemiology and Population Health, Institut de Cancérologie Gustave Roussy, Villejuif, France.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Slattery ML; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Smith JD; Department Genome Sciences, University of Washington, 98195, Seattle, WA, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Trichopoulou A; Hellenic Health Foundation, 13 Kaisareias & Alexandroupoleos, 115 27, Athens, Greece.; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 115 27, Athens, Greece.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Tumino R; Affiliation Cancer Registry, Department of Prevention, Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Ulrich CM; Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, 84112, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., van Duijnhoven FJB; Division of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Van Guelpen B; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Weinstein SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., White E; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Wolk A; Institute of Environmental Medicine, Karolinska Institutet Solna, 17177, Stockholm, Sweden.; Department of Surgical Sciences, Uppsala University, 75121, Uppsala, Sweden.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Woods MO; Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, Saint John's, NL, A1B 3V6, Canada.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Wu AH; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Abecasis GR; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Casey G; Centre for Research in Epidemiology and Population Health, Institut de Cancérologie Gustave Roussy, Villejuif, France.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Nickerson DA; Department Genome Sciences, University of Washington, 98195, Seattle, WA, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Gruber SB; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Hsu L; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Zheng W; Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

Publikováno v: Human genetics [Hum Genet] 2019 Apr; Vol. 138 (4), pp. 307-326. Date of Electronic Publication: 2019 Feb 28.

Discovery of common and rare genetic risk variants for colorectal cancer.

Autor: Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Bien SA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Chen S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmit SL; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Conti DV; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jeon J; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Edlund CK; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Greenside P; Biomedical Informatics Program, Stanford University, Stanford, CA, USA., Wainberg M; Department of Computer Science, Stanford University, Stanford, CA, USA., Schumacher FR; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Smith JD; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Levine DM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Sinnott-Armstrong NA; Department of Genetics, Stanford University, Stanford, CA, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Alonso MH; Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain., Anderson K; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Arnau-Collell C; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain., Arndt V; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bamia C; Hellenic Health Foundation, Athens, Greece.; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Banbury BL; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Baron JA; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Bézieau S; Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France., Bishop DT; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Boehm J; Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA., Boeing H; Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Brezina S; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Buch S; Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia., Burnett-Hartman A; Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA., Butterbach K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Caan BJ; Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA, USA., Campbell PT; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA., Carlson CS; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Castellví-Bel S; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain., Chan AT; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Chirlaque MD; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain., Cho SH; Department of Hematology-Oncology, Chonnam National University Hospital, Hwasun, South Korea., Connolly CM; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Cross AJ; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Cuk K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Curtis KR; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., de la Chapelle A; Department of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Doheny KF; Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Duggan D; Translational Genomics Research Institute - An Affiliate of City of Hope, Phoenix, AZ, USA., Easton DF; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Elias SG; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Elliott F; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., English DR; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia., Feskens EJM; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands., Figueiredo JC; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Fischer R; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA., FitzGerald LM; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Forman D; International Agency for Research on Cancer, World Health Organization, Lyon, France., Gala M; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Gauderman WJ; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Giles GG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia., Gillanders E; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA., Gong J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Goodman PJ; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Grady WM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Grove JS; University of Hawaii Cancer Research Center, Honolulu, HI, USA., Gsur A; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Gunter MJ; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France., Haile RW; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA., Hampe J; Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany., Hampel H; Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Harlid S; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden., Hayes RB; Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA., Hofer P; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea., Hsu WL; Department of Biostatistics, University of Washington, Seattle, WA, USA., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hudson TJ; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Hunter DJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Ibañez-Sanz G; Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Gastroenterology Department, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain., Idos GE; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Ingersoll R; Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Jackson RD; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, USA., Jacobs EJ; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Joshi AD; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. 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Publikováno v: Nature genetics [Nat Genet] 2019 Jan; Vol. 51 (1), pp. 76-87. Date of Electronic Publication: 2018 Dec 03.

Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

Autor: Schumacher FR; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Schmit SL; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA., Jiao S; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Edlund CK; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Wang H; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA., Zhang B; Department of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Huang SC; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Fischer CP; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA., Harju JF; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA., Idos GE; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Lejbkowicz F; Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.; Clalit Health Services National Cancer Control Center, Haifa 34361, Israel., Manion FJ; University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA., McDonnell K; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., McNeil CE; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Melas M; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Rennert HS; Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.; Clalit Health Services National Cancer Control Center, Haifa 34361, Israel., Shi W; Department of Surgery, Children's Hospital Los Angeles, Los Angeles, California 90027, USA., Thomas DC; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Van Den Berg DJ; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Hutter CM; Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA., Aragaki AK; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Butterbach K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany., Caan BJ; Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA., Carlson CS; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA., Curtis KR; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Fuchs CS; Department of Medicine, Brigham and Women's Hospital, Brookline, Massachusetts 02115, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, Massachusetts 02115, USA., Gala M; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Giovannucci EL; Harvard Medical School, Boston, Massachusetts 02114, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Hayes RB; Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA., Henderson B; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Hunter DJ; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Jackson RD; Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA., Kolonel LN; Office of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Küry S; Service de Génétique Médicale, CHU Nantes, Nantes 44093, France., LaCroix A; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Laurie CC; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Laurie CA; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Lemire M; Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Levine D; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Ma J; Harvard School of Public Health, Boston, Massachusetts 02114, USA., Makar KW; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Taverna D; Phoenix College, Phoenix, Arizona 85013, USA., Ulrich CM; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.; Division of Preventive Oncology, German Cancer Research Center, Heidelberg 69120, Germany.; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA., Wu K; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Kono S; Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan., West DW; Cancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA., Bezieau S; Centre Hospitalier Universitaire Hotel-Dieu, Nantes, 44093, France., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany., Campbell PT; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA., Chan AT; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Harvard Medical School, Boston, Massachusetts 02114, USA., Chang-Claude J; Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany., Coetzee GA; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Conti DV; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Duggan D; Genetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA., Figueiredo JC; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Fortini BK; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Gallinger SJ; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada., Gauderman WJ; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Giles G; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia., Green R; Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6, Canada., Haile R; Department of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany., Hopper JL; Centre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia., Hudson TJ; Department of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Jacobs E; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA., Iwasaki M; Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan., Jee SH; Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea., Jenkins M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia., Jia WH; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China., Joshi A; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Li L; Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA., Lindor NM; Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA., Matsuo K; Department of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan., Moreno V; Cancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL, 08908, Barcelona, Spain., Mukherjee B; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Newcomb PA; Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Potter JD; Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Raskin L; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.; Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA., Rennert G; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.; Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.; Clalit Health Services National Cancer Control Center, Haifa 34361, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3200003, Israel., Rosse S; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Severi G; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.; Human Genetics Foundation (HuGeF), Torino 10126, Italy., Schoen RE; Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA., Seminara D; Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Shu XO; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.; Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA., Slattery ML; Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA., Tsugane S; Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan., White E; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA., Xiang YB; Department of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China., Zanke BW; The University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1Y 4E9, Canada., Zheng W; Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA., Casey G; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Gruber SB; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.

Publikováno v: Nature communications [Nat Commun] 2015 Jul 07; Vol. 6, pp. 7138. Date of Electronic Publication: 2015 Jul 07.