Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.

Autor: Homan CC; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Drazer MW; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Yu K; Division of Intramural Research, Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Lawrence DM; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia., Feng J; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia., Arriola-Martinez L; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Pozsgai MJ; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., McNeely KE; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Ha T; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Venugopal P; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Arts P; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., King-Smith SL; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Cheah J; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Armstrong M; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Wang P; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia., Bödör C; HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Cantor AB; Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Cazzola M; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Degelman E; Alberta Children's Hospital, Calgary, Alberta, Canada., DiNardo CD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Duployez N; Laboratory of Hematology, Biology and Pathology Center, Centre Hospitalier Regional Universitaire de Lille, Lille, France.; Jean-Pierre Aubert Research Center, INSERM, Universitaire de Lille, Lille, France., Favier R; Assistance Publique-Hôpitaux de Paris, Armand Trousseau Children's Hospital, Paris, France., Fröhling S; Department of Translational Medical Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Rio-Machin A; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Klco JM; St Jude Children's Research Hospital, Memphis, TN., Krämer A; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany., Kurokawa M; Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Lee J; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore., Malcovati L; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Morgan NV; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Natsoulis G; Imago Biosciences, Inc, San Francisco, CA., Owen C; Division of Hematology and Hematological Malignancies, Foothills Medical Centre, Calgary, AB, Canada., Patel KP; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Preudhomme C; Laboratory of Hematology, Biology and Pathology Center, Centre Hospitalier Regional Universitaire de Lille, Lille, France.; Jean-Pierre Aubert Research Center, INSERM, Universitaire de Lille, Lille, France., Raslova H; Institut Gustave Roussy, Université Paris Sud, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villejuif, France., Rienhoff H; Imago Biosciences, Inc, San Francisco, CA., Ripperger T; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Schulte R; Division of Pediatric Hematology and Oncology, Riley Children's Hospital, Indiana University School of Medicine, Indianapolis, IN., Tawana K; Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom., Velloso E; Service of Hematology, Transfusion and Cell Therapy and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31) HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil.; Genetics Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Yan B; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore., Kim E; National Cancer Institute, National Institutes of Health, Rockville, MD., Sood R; Division of Intramural Research, Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Hsu AP; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Holland SM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Phillips K; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Poplawski NK; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Babic M; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia., Wei AH; Department of Haematology, Peter McCallum Cancer Centre, Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, The University of Melbourne, Melbourne, VIC, Australia., Forsyth C; Central Coast Haematology, North Gosford, NSW, Australia., Mar Fan H; Department of Medicine, The University of Queensland, Brisbane, QLD, Australia., Lewis ID; Adelaide Oncology & Haematology, North Adelaide, SA, Australia., Cooney J; Department of Haematology, Fiona Stanley Hospital, Murdoch, WA, Australia., Susman R; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Fox LC; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Blombery P; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Singhal D; Department of Haematology, SA Pathology, Adelaide, SA, Australia., Hiwase D; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.; Department of Haematology, SA Pathology, Adelaide, SA, Australia., Phipson B; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Paediatrics and Department of Molecular Biology, The University of Melbourne, Melbourne, VIC, Australia., Schreiber AW; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia.; School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia., Hahn CN; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Scott HS; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; ACRF Genomics Facility, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, SA, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia., Liu P; Division of Intramural Research, Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Godley LA; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, Center for Clinical Cancer Genetics, and The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Brown AL; Department of Genetics and Molecular Pathology, Centre for Cancer Biology, An alliance between SA Pathology and the University of South Australia, Adelaide, Australia.; UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.; Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.

Publikováno v: Blood advances [Blood Adv] 2023 Oct 24; Vol. 7 (20), pp. 6092-6107.

Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.

Autor: Drazer MW; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL.; Department of Human Genetics, University of Chicago, Chicago, IL., Homan CC; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia., Yu K; National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD., Cavalcante de Andrade Silva M; Hospital Universitário Prof Alberto Antunes/Universidade Federal de Alagoas, Maceio, Brazil., McNeely KE; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL., Pozsgai MJ; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL., Acevedo-Mendez MG; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL., Segal JP; Department of Pathology, University of Chicago, Chicago, IL., Wang P; Department of Pathology, University of Chicago, Chicago, IL., Feng J; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia., King-Smith SL; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia., Kim E; National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD., Korotev S; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL., Lawrence DM; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia., Schreiber AW; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia.; School of Biological Sciences, University of Adelaide, Adelaide, South Australia., Hahn CN; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia.; School of Medicine, University of Adelaide, Adelaide, South Australia., Scott HS; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia.; School of Medicine, University of Adelaide, Adelaide, South Australia., Sood R; National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD., Velloso EDRP; Service of Hematology, Transfusion and Cell Therapy and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31) HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil; and.; Genetics Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Brown AL; Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, South Australia.; Center for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia.; School of Medicine, University of Adelaide, Adelaide, South Australia., Liu PP; National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD., Godley LA; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL.; Department of Human Genetics, University of Chicago, Chicago, IL.

Publikováno v: Blood advances [Blood Adv] 2022 Aug 09; Vol. 6 (15), pp. 4357-4359.

Challenges associated with the identification of germline variants on myeloid malignancy genomic profiling-a Singaporean experience.

Autor: Hui-Lin Chin, Joyce Ching Mei Lam, Dheepa Christopher, Poon Limei Michelle, Benedict Yan Junrong

Publikováno v: Frontiers in Oncology; 2023, p1-9, 9p