Zobrazeno 1 - 10
of 132
pro vyhledávání: '"McN5652"'
Publikováno v:
Nuclear Medicine and Biology. 43:470-477
Serotonin transporters (SERT) in the brain play an important role in normal brain function. Selective serotonin reuptake inhibitors such as fluoxetine, sertraline, paroxetine, escitalopram, etc., specifically target SERT binding in the brain. Develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef87ea6b064db9c497b50e72fe11f22
https://doi.org/10.1016/j.nucmedbio.2016.04.003
https://doi.org/10.1016/j.nucmedbio.2016.04.003
Autor:
Hongwen Qiao, Genxun Li, Zhihao Zha, Karl Plössl, Hank F. Kung, Seok Rye Choi, Lin Zhu, Piu Chan
Publikováno v:
Nuclear Medicine and Biology. 40:974-979
Introduction In vivo positron emission tomography (PET) imaging of the serotonin transporter (SERT) is a valuable tool in drug development and in monitoring brain diseases with altered serotonergic function. We have developed a two-step labeling reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33aa97b556aef67b508b403f03b938a
https://doi.org/10.1016/j.nucmedbio.2013.08.002
https://doi.org/10.1016/j.nucmedbio.2013.08.002
Publikováno v:
Nuclear Medicine and Biology. 40:879-886
Introduction Biological evaluation of [ 125 I]FlipIDAM (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol ([ 125 I]4), a new single-photon emission computed tomography (SPECT) radioligand for imaging the serotonin transporter (SERT) whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a7a4869e83b0616528e693f190c251
https://doi.org/10.1016/j.nucmedbio.2013.06.001
https://doi.org/10.1016/j.nucmedbio.2013.06.001
Autor:
Gregory M. Sullivan, Ramin V. Parsey, Maria A. Oquendo, R. Todd Ogden, Jeffrey M. Miller, J. John Mann, Natalie Hesselgrave
Publikováno v:
Biological Psychiatry. 74:287-295
Background Several lines of evidence implicate abnormal serotonergic function in suicidal behavior and completed suicide, including low serotonin transporter binding in postmortem studies of completed suicide. We have also reported low in vivo seroto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfee8dc5ca7665c5e02f1c391632536
https://doi.org/10.1016/j.biopsych.2013.01.024
https://doi.org/10.1016/j.biopsych.2013.01.024
Autor:
Kazuhiko Nakayama, Yoko Ikoma, Ryohei Matsumoto, Jun Kosaka, Akihiro Takano, Yota Fujimura, Ryosuke Arakawa, Tetsuya Suhara, Kenji Fukui, Hidehiko Takahashi, Miho Ota, Hiroshi Ito, Masanori Ichise, Tomomichi Ando
Publikováno v:
NeuroImage. 49:121-126
The serotonin transporter (5-HTT) and other markers of the serotonergic system have been of interest in the pathophysiology of obsessive-compulsive disorder (OCD). Previous studies using single photon emission computed tomography (SPECT) with [(123)I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cc91deb127e0aba7a92b30b9e23798
https://doi.org/10.1016/j.neuroimage.2009.07.069
https://doi.org/10.1016/j.neuroimage.2009.07.069
Publikováno v:
Nuclear Medicine and Biology. 35:447-458
Introduction A new 18 F ligand, 2-(2′-((dimethylamino)methyl)-4′-(3-[ 18 F]fluoropropoxy)-phenylthio)benzenamine ([ 18 F] 1 ), for positron emission tomography (PET) imaging of serotonin transporters (SERT) was evaluated. Methods Binding affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cec9e0bcaac91d505ba74dd0e96559a
https://doi.org/10.1016/j.nucmedbio.2008.02.009
https://doi.org/10.1016/j.nucmedbio.2008.02.009
Autor:
Makoto Inoue, Fumihiko Yasuno, Hiroshi Ito, Yasuhiko Sudo, Tetsuya Ichimiya, Kazutoshi Suzuki, Akihiro Takano, Tetsuya Suhara
Publikováno v:
Annals of Nuclear Medicine. 21:349-354
The lung is one of the key organs for determining the distribution of drugs in the human body. Various factors influence the accumulation of drugs. In this study, we investigated the effects of smoking on drug distribution to the lung using radiolabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f971aa7e860cebe22e27ab1fbc564ba6
https://doi.org/10.1007/s12149-007-0031-1
https://doi.org/10.1007/s12149-007-0031-1
Autor:
Florian Wilke, Winfried Brenner, Malte Clausen, Janos Mester, Kay Uwe Petersen, Ralph Buchert, Lothar Spies, Rainer Thomasius, Frank Thiele
Publikováno v:
Journal of Psychopharmacology. 21:628-634
In a previous positron emission tomography (PET) study with the serotonin transporter (SERT) ligand [11C](+)McN5652, we found protracted reduction of the availability of the brain SERT in users of the drug ecstasy. However, the multi-linear reference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3316dc5591f0baf17198af767c7b301b
https://doi.org/10.1177/0269881106071975
https://doi.org/10.1177/0269881106071975
Autor:
Pál Mikecz, Winfried Brenner, Malte Clausen, Oliver Schulze, Matthias Reimold, Thomas Rädler, Patrick Schloss, Ralph Buchert, René Hummerich
Publikováno v:
Nuclear Medicine and Biology. 33:317-323
Introduction Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [ 11 C] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c67611aba097a724930921ab612aab
https://doi.org/10.1016/j.nucmedbio.2005.12.009
https://doi.org/10.1016/j.nucmedbio.2005.12.009
Autor:
Shigeyuki Yamamoto, Hirotaka Onoe, Hirohiko Kuratsune, Hideo Tsukada, Etsuji Yoshikawa, Yasuyoshi Watanabe, Masao Iwase, Kouzi Yamaguti, Yasuomi Ouchi, Hidetoshi Takahashi
Publikováno v:
NeuroReport. 15:2571-2574
To assess the involvement of serotonin in the symptoms of chronic fatigue syndrome, we investigated the serotonergic neurotransmitter system of chronic fatigue syndrome patients by the positron emission tomography (PET). Here we show that the density
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ff09bb39f80b8cd533af1ea76ee751
https://doi.org/10.1097/00001756-200412030-00002
https://doi.org/10.1097/00001756-200412030-00002