Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Autor: Su, Z., Gay, L.J., Strange, A., Palles, C., Band, G., Whiteman, D.C., Lescai, F., Langford, C., Nanji, M., Edkins, S., van der Winkel, A., Levine, D., Sasieni, P., Bellenguez, C., Howarth, K., Freeman, C., Trudgill, N., Tucker, A.T., Pirinen, M., Peppelenbosch, M.P., van der Laan, L.J.W., Kuipers, E.J., Drenth, J.P.H., Peters, W.H., Reynolds, J.V., Kelleher, D.P., McManus, R., Grabsch, H., Prenen, H., Bisschops, R., Krishnadath, K., Siersema, P.D., van Baal, J.W.P.M., Middleton, M., Petty, R., Gillies, R., Burch, N., Bhandari, P., Paterson, S., Edwards, C., Penman, I., Vaidya, K., Ang, Y., Murray, I., Patel, P., Ye, W., Mullins, P., Wu, A.H., Bird, N.C., Dallal, H., Shaheen, N.J., Murray, L.J., Koss, K., Bernstein, L., Romero, Y., Hardie, L.J., Zhang, R., Winter, H., Corley, D.A., Panter, S., Risch, H.A., Reid, B.J., Sargeant, I., Gammon, M.D., Smart, H., Dhar, A., McMurtry, H., Ali, H., Liu, G., Casson, A.G., Chow, W.-H., Rutter, M., Tawil, A., Morris, D., Nwokolo, C., Isaacs, P., Rodgers, C., Ragunath, K., MacDonald, C., Haigh, C., Monk, D., Davies, G., Wajed, S., Johnston, D., Gibbons, M., Cullen, S., Church, N., Langley, R., Griffin, M., Alderson, D., Deloukas, P., Hunt, S.E., Gray, E., Dronov, S., Potter, S.C., Tashakkori-Ghanbaria, A., Anderson, M., Brooks, C., Blackwell, J.M., Bramon, E., Brown, M.A., Casas, J.P., Corvin, A., Duncanson, A., Markus, H.S., Mathew, C.G., Palmer, C.N.A., Plomin, R., Rautanen, A., Sawcer, S.J., Trembath, R.C., Viswanathan, A.C., Wood, N., Trynka, G., Wijmenga, C., Cazier, J.-B., Atherfold, P., Nicholson, A.M., Gellatly, N.L., Glancy, D., Cooper, S.C., Cunningham, D., Lind, T., Hapeshi, J., Ferry, D., Rathbone, B., Brown, J., Love, S., Attwood, S., MacGregor, S., Watson, P., Sanders, S., Ek, W., Harrison, R.F., Moayyedi, P., de Caestecker, J., Barr, H., Stupka, E., Vaughan, T.L., Peltonen, L., Spencer, C.C.A., Tomlinson, I., Donnelly, P., Jankowski, J.A.Z., Genetics, E.A., Consor, W.T.C.C.

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report t

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https://openaccess.sgul.ac.uk/id/eprint/107304/7/licence.docx

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Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.

Autor: Palles C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address: cpalles@well.ox.ac.uk., Chegwidden L; Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, Devon, UK., Li X; Centre of Biostatistics, Bioinformatics and Biomarkers, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, Devon, UK., Findlay JM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Farnham G; Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, Devon, UK., Castro Giner F; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Kovac M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Adams CL; Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, Devon, UK., Prenen H; Department of Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium., Briggs S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Harrison R; Department of Pathology, Leicester Royal Infirmary, Leicester, UK., Sanders S; Department of Cellular Pathology, Warwick Hospital, Warwick, UK., MacDonald D; Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Haigh C; Department of Gastroenterology, Wansbeck General Hospital, Ashington, Northumberland, UK., Tucker A; William Harvey Research Institute, The Ernest Cooke Vascular & Microvascular Unit, Centre for Clinical Pharmacology, St Bartholomew's Hospital, London, UK., Love S; Centre for Statistics in Medicine and Oxford Clinical Trials Research Unit, Oxford, UK., Nanji M; Centre for Digestive Diseases, Queen Mary University of London, London, UK., deCaestecker J; Department of Gastroenterology, Leicester General Hospital, Leicester, UK., Ferry D; Department of Oncology, New Cross Hospital, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK., Rathbone B; Department for Gastroenterology, Leicester Royal Infirmary, Leicester, UK., Hapeshi J; Gloucestershire Royal Hospital, Great Western Road, Gloucester, UK., Barr H; Department of Upper GI Surgery, Gloucestershire, Royal Hospital, Gloucester, UK., Moayyedi P; Department of Medicine, McMaster HC, Hamilton Ontario, Canada., Watson P; School of Medicine, Dentistry, and Biomedical Sciences, Centre for Public Health, Queens University Belfast, NI., Zietek B; Centre for Digestive Diseases, Queen Mary University of London, London, UK., Maroo N; Centre for Digestive Diseases, Queen Mary University of London, London, UK., Gay L; Centre for Digestive Diseases, Queen Mary University of London, London, UK., Underwood T; University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK., Boulter L; University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK., McMurtry H; Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital, Lancashire, UK., Monk D; General Surgery, Countess of Chester Hospital, Chester, UK., Patel P; Southampton University Hospitals NHS Trust, Southampton, UK., Ragunath K; Wolfson Digestive Diseases Centre, Queens Medical Centre, Nottingham, UK., Al Dulaimi D; Worcestershire Acute Hospitals NHS Trust, Alexandra Hospital, Redditch, UK., Murray I; Department of Gastroenterology, Royal Cornwall Hospital, Truro, Cornwall, UK., Koss K; Macclesfield General Hospital, Macclefield, Cheshire, UK., Veitch A; Department of Oncology, New Cross Hospital, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK., Trudgill N; Department of Gastroenterology, Sandwell General Hospital, Lyndon, West Bromwich, UK., Nwokolo C; Department of Gastroenterology, University Hospital of Coventry, Coventry, UK., Rembacken B; Department of Gastroenterology, Leeds General Infirmary, Leeds, UK., Atherfold P; Department of Clinical Pharmacology University of Oxford, Oxford, UK., Green E; School of Biomedical & Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK., Ang Y; Gastroenterology, Royal Albert Edward Infirmary NHS Trust, Wigan, UK; GI Science Centre, Salford Royal NHS Foundation Trust, University of Manchester, Salford, UK., Kuipers EJ; Department of Gastroenterology and Hepatology, Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Chow W; Forth Valley Royal Hospital, Larbert, Scotland, UK., Paterson S; Norfolk and Norwich University Hospitals NHS Foundation Trust, Norfolk and Norwich University Hospital, Norwich, UK., Kadri S; Department for Gastroenterology, Leicester Royal Infirmary, Leicester, UK., Beales I; Burnley General Hospital, Burnley, Lancashire, UK., Grimley C; Head of Gastroenterology, University Hospital of Northern BC, Prince George, British Columbia, Canada., Mullins P; Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford, UK., Beckett C; Royal United Hospital Bath NHS Trust, Royal United Hospital, Avon, Bath, Somerset, UK., Farrant M; Kettering General Hospital NHS Foundation Trust, Kettering General Hospital, Rothwell Road, Kettering, Northants, UK., Dixon A; York Teaching Hospital NHS Foundation Trust, York, UK., Kelly S; Luton and Dunstable University Hospital NHS Foundation Trust, Luton, Bedfordshire, UK., Johnson M; Department of Thoracic and Upper Gastrointestinal Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Wajed S; County and Durham and Darlington NHS Foundation Trust, Bishop Auckland, County Durham, UK., Dhar A; Guy's and St Thomas' NHS Foundation Trust, London, UK., Sawyer E; Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK., Roylance R; Division of Public Health Sciences, Fred Hutchinson Cancer Research Centre, Seattle, Washington., Onstad L; Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina., Gammon MD; Division of Research and San Francisco Medical Center, Kaiser Permanente Northern California, California., Corley DA; Division of Gastroenterology and Hepatology, UNC School of Medicine, University of North Carolina, Chapel Hill, North Carolina., Shaheen NJ; Department of Oncology, The Medical School, University of Sheffield, UK., Bird NC; Division of Epidemiology, University of Leeds, Leeds, UK., Hardie LJ; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington., Reid BJ; Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Ye W; Princess Margaret Cancer Centre, Ontario Cancer Institute, Toronto, ON, Canada., Liu G; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Romero Y; Registry, On behalf of the Romero; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California., Bernstein L; Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California., Wu AH; Department of Surgery, University of Saskatchewan, Saskatoon, Canada., Casson AG; MRC Cancer Cell Unit, Hutchison-MRC Research Centre and University of Cambridge, Cambridge, UK., Fitzgerald R; Cancer Control, QIMR Berghofer Medical Research Institute, Queensland, Australia., Whiteman DC; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Risch HA; Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington., Levine DM; Department of Gastroenterology, Tergooi Hospital, Hilversum, The Netherlands., Vaughan TL; Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina., Verhaar AP; Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., van den Brande J; Department of Surgery, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Toxopeus EL; Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands., Spaander MC; Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Wijnhoven BP; Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands., van der Laan LJ; Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands., Krishnadath K; Department of Genetics, University Medical Centre Groningen and University of Groningen, The Netherlands., Wijmenga C; Department of Clinical Medicine & Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland., Trynka G; Department of Clinical Medicine & Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin, Ireland., McManus R; Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St. James' Hospital, Dublin, Ireland., Reynolds JV; Gastrointestinal Unit, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland., O'Sullivan J; Gastrointestinal Unit, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland., MacMathuna P; Faculty of Medicine, Imperial College London, South Kensington Campus, London, UK., McGarrigle SA; Gastrointestinal Unit, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland., Kelleher D; Faculty of Medicine, Imperial College, South Kensington Campus, London, UK., Vermeire S; Department of Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium., Cleynen I; Department of Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium., Bisschops R; Department of Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium., Tomlinson I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address: iant@well.ox.ac.uk., Jankowski J; University Hospitals Coventry & Warwickshire NHS Trust, Warwickshire, England; Warwick Medical School, University of Warwick, Warwickshire, England. Electronic address: J.Jankowski@warwick.ac.uk.

Publikováno v: Gastroenterology [Gastroenterology] 2015 Feb; Vol. 148 (2), pp. 367-78. Date of Electronic Publication: 2014 Nov 05.