Zobrazeno 1 - 10
of 22
pro vyhledávání: '"McMillan, Lynette"'
Autor:
Bee, Weilin Tiger, Xie, Wensheng, Truong, Maggie, Will, Matthew, Turunen, Brandon, Zuercher, William J., McMillan, Lynette, Li, Hu, Hornberger, Keith R. **, Davenport, Elizabeth A., Ames, Robert S., Kallal, Lorena A. *
Publikováno v:
In SLAS Discovery August 2012 17(7):900-911
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1988 Nov 01. 85(21), 8027-8031.
Externí odkaz:
https://www.jstor.org/stable/32562
Autor:
Mcmillan Lynette Jane, David J. Behm, Jian Jin, Kalindi Vaidya, Zining Wu, Michael J. Neeb, Dongchuan Shi, Karl F. Erhard, Feng Wang, Brian F. Guida, Sarah K. Lawrence, Christopher P. Evans, Stephen A. Douglas, Yonghui Wang, Ralph A. Rivero, Jyoti Disa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2860-2864
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93b7e819e4a3037dabc6f377d61bfb1
https://doi.org/10.1016/j.bmcl.2008.03.078
https://doi.org/10.1016/j.bmcl.2008.03.078
Autor:
Brandon J. Turunen, William J. Zuercher, Elizabeth A. Davenport, Mcmillan Lynette Jane, Robert S. Ames, Lorena A. Kallal, Maggie Truong, Keith R. Hornberger, M. Will, Wensheng Xie, Weilin Tiger Bee, Hu Li
Publikováno v:
Journal of biomolecular screening. 17(7)
In this study, the development of an image-based high-content screening (HCS) binding assay for the seven-transmembrane (7TM) receptor Smoothened (Smo) is described. Using BacMam-based gene delivery of Smo, BODIPY-cyclopamine as a fluorescent probe,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f72c01c95c035395ad76782668c710
https://pubmed.ncbi.nlm.nih.gov/22644265
https://pubmed.ncbi.nlm.nih.gov/22644265
Autor:
Mcmillan Lynette Jane, William J. Zuercher, Cynthia M. Rominger, Peter J. Tummino, Quinn Lu, Zhihong Lai, Brandon J. Turunen, David H. Rominger, Aidan G. Gilmartin, Lorena A. Kallal, Elizabeth A. Davenport, Keith R. Hornberger, Richard R. Gontarek, M. Will, Weilin Tiger Bee, Kenneth W. M. Lawrie, Maggie Truong, Robert A. Copeland
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 329(3)
The Smoothened receptor (Smo) mediates hedgehog (Hh) signaling critical for development, cell growth, and migration, as well as stem cell maintenance. Aberrant Hh signaling pathway activation has been implicated in a variety of cancers, and small-mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c940469e2abba6848dd0c5453b7da1
https://pubmed.ncbi.nlm.nih.gov/19304771
https://pubmed.ncbi.nlm.nih.gov/19304771
Autor:
Mcmillan Lynette Jane, James J. Foley, Paul R. Murdock, Philip G. Szekeres, Shelagh Wilson, Andrew J. Murphy, Sajda Naheed, Claire Scott, George P. Livi, Jon K. Chambers, Derk J. Bergsma, Emir Duzic, Katie Freeman, John J. Trill, Henry M. Sarau, Christine Klein, Paul H. Taylor, Macdonald Lynn, Nambi Aiyar, Ann M. Swift, Robert S. Ames, Jeanette M. Watson, Yuan Zhu, Guillaume Hervieu, Lisa Vawter, Megan M. McLaughlin
Publikováno v:
The Journal of biological chemistry. 275(15)
Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP-glucose may possess pharmacological activity, suggesting that a rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbd9f8b03890fe0a23d00a07904ad2a
https://pubmed.ncbi.nlm.nih.gov/10753868
https://pubmed.ncbi.nlm.nih.gov/10753868
Autor:
Nabil Elshourbagy, Jeffrey L. Mooney, Mcmillan Lynette Jane, Hsiao-Ling Wu, Sharon Butler, Angela M. Smith, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Derk J. Bergsma, Jane Miller, Gillian I. Rennie, Alison I. Muir, Lisa D. Spinage, Stephanie E. Guerrera, Jon K. Chambers, Lisa Vawter, Paul R. Murdock
Publikováno v:
The Journal of biological chemistry. 275(27)
Neuromedins are a family of peptides best known for their contractile activity on smooth muscle preparations. The biological mechanism of action of neuromedin U remains unknown, despite the fact that the peptide was first isolated in 1985. Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b50352840720622422e05ab40d94f1f
https://pubmed.ncbi.nlm.nih.gov/10811630
https://pubmed.ncbi.nlm.nih.gov/10811630
Autor:
Jin, Jian, Wang, Yonghui, Wang, Feng, Shi, Dongchuan, Erhard, Karl F., Wu, Zining, Guida, Brian F., Lawrence, Sarah K., Behm, David J., Disa, Jyoti, Vaidya, Kalindi S., Evans, Christopher, McMillan, Lynette J., Rivero, Ralph A., Neeb, Michael J., Douglas, Stephen A.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2008 18(9):2860-2864
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Autor:
Szekeres, Philip G., Muir, Alison I., Spinage, Lisa D., Miller, Jane E., Butler, Sharon I., Smith, Angela, Rennie, Gillian I., Murdock, Paul R., Fitzgerald, Laura R., Wu, Hsiao-ling, McMillan, Lynette J., Guerrera, Stephanie, Vawter, Lisa, Elshourbagy, Nabil A., Mooney, Jeffrey L., Bergsma, Derk J., Wilson, Shelagh, Chambers, Jon K.
Publikováno v:
Journal of Biological Chemistry; July 2000, Vol. 275 Issue: 27 p20247-20250, 4p