Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer.

Autor: McLoed AG; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA., Sherrill TP; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA., Cheng DS; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA., Han W; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA., Saxon JA; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA., Gleaves LA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA., Wu P; Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, USA., Polosukhin VV; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA., Karin M; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Yull FE; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, 691 Preston Building, 2220 Pierce Ave., Nashville, TN 37232, USA., Stathopoulos GT; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA; Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, University of Patras, Rio, 26504 Patras, Greece; Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich 81377, Germany., Georgoulias V; Department of Medical Oncology, University General Hospital of Heraklion, Heraklion, Crete 71110, Greece., Zaynagetdinov R; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: rinat.z.zaynagetdinov@vanderbilt.edu., Blackwell TS; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, 691 Preston Building, 2220 Pierce Ave., Nashville, TN 37232, USA; U.S. Department of Veterans Affairs, Washington, DC 20420, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232 USA.

Publikováno v: Cell reports [Cell Rep] 2016 Jun 28; Vol. 16 (1), pp. 120-132. Date of Electronic Publication: 2016 Jun 16.

p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment.

Autor: Saxon JA; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232;, Cheng DS; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232;, Han W; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232;, Polosukhin VV; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232;, McLoed AG; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232;, Richmond BW; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232; and., Gleaves LA; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232;, Tanjore H; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232;, Sherrill TP; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232;, Barham W; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232;, Yull FE; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232;, Blackwell TS; Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232; and Department of Veterans Affairs Medical Center, Nashville, TN 37232 timothy.blackwell@vanderbilt.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Feb 15; Vol. 196 (4), pp. 1891-9. Date of Electronic Publication: 2016 Jan 15.

Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.

Autor: Zaynagetdinov R; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN, USA, 37232., Sherrill TP; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN, USA, 37232., Gleaves LA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN, USA, 37232., McLoed AG; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA, 37232., Saxon JA; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA, 37232., Habermann AC; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN, USA, 37232., Connelly L; Department of Pharmaceutical Sciences, University of Hawaii, Hilo, Hawaii, USA, 96720., Dulek D; Department of Pediatrics, Vanderbilt University, Nashville, TN, USA, 37232., Peebles RS Jr; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN, USA, 37232.; U.S. Department of Veterans Affairs., Fingleton B; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA, 37232., Yull FE; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA, 37232.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA, 37232., Stathopoulos GT; Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, University of Patras, 26504 Rio, Greece., Blackwell TS; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN, USA, 37232.; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA, 37232.; U.S. Department of Veterans Affairs.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA, 37232.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA, 37232.

Publikováno v: Cancer research [Cancer Res] 2015 Apr 15; Vol. 75 (8), pp. 1624-1634. Date of Electronic Publication: 2015 Feb 17.

A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.

Autor: Zaynagetdinov R; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, Yull FE, Blackwell TS

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 Dec 01; Vol. 187 (11), pp. 5703-11. Date of Electronic Publication: 2011 Nov 02.