Zobrazeno 1 - 10
of 835
pro vyhledávání: '"McLeod, HL"'
Publikováno v:
OncoTargets and Therapy, Vol Volume 11, Pp 6969-6980 (2018)
Ping Liao,1 Wei Li,1 Ruizheng Liu,2 Jamie K Teer,2 Biaobo Xu,3 Wei Zhang,1 Xi Li,1 Howard L Mcleod,1,2 Yijing He1,2 1Hunan Key Laboratory of Pharmacogenetics, Department of Clinical Pharmacology, Institute of Clinical Pharmacology, Xiangya Hospital,
Publikováno v:
Pharmacogenomics. 7:625-631
With pharmacogenetics comes the promise of individualized therapy selection for many common diseases where multiple treatment options are available. Recent advances including the Human Genome Project, the International HapMap project, advances in thr
Autor:
Kwok, Pui-Yan, Hariani, GD, Lam, EJ, Havener, T, Kwok, PY, McLeod, HL, Wagner, MJ, Motsinger-Reif, AA
Publikováno v:
Kwok, Pui-Yan; Hariani, GD; Lam, EJ; Havener, T; Kwok, PY; McLeod, HL; et al.(2014). Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7rk607rd
Background: The goal of this study was to perform candidate gene association with cytotoxicity of chemotherapeutics in cell line models through resequencing and discovery of rare and low frequency variants along with common variations. Here, an assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::f50b1431541cd516cfef093369d6cf29
http://www.escholarship.org/uc/item/7rk607rd
http://www.escholarship.org/uc/item/7rk607rd
Autor:
Chhibber, A, Mefford, J, Stahl, EA, Pendergrass, SA, Baldwin, RM, Owzar, K, Li, M, Winer, EP, Hudis, CA, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, HL, Ratain, MJ, Shulman, LN, Ritchie, MD, Plenge, RM, Witte, JS, Kroetz, DL
Publikováno v:
Pharmacogenomics Journal, vol 14, iss 4
Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that predispose patients to the adverse event, and pathogenesis for paclitaxel-induced peripheral neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e70e960aba4b968132671fec06d80631
https://escholarship.org/uc/item/53n789q6
https://escholarship.org/uc/item/53n789q6
A polymorphism in the VKORC1-regulator calumenin predicts higher warfarin doses in African-Americans
Autor:
Voora, D, Koboldt, DC, King, CR, Lenzini, PA, Eby, CS, Porche-Sorbet, R, Deych, E, Crankshaw, M, Milligan, PE, McLeod, HL, Patel, SR, Cavallari, LH, Ridker, PM, Grice, GR, Miller, RD, Gage, BF
Warfarin demonstrates a wide interindividual variability in response that is mediated partly by variants in cytochrome P450 2C9 (CYP2C9) and vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1). It is not known whether variants in calumenin (CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3211081ac80da049e071965d9b8957cd
https://europepmc.org/articles/PMC2928561/
https://europepmc.org/articles/PMC2928561/
Autor:
Moriyama, B, Obeng, A Owusu, Barbarino, J, Penzak, SR, Henning, SA, Scott, SA, Agúndez, JAG, Wingard, JR, McLeod, HL, Klein, TE, Cross, SJ, Caudle, KE, Walsh, TJ
Publikováno v:
Clinical Pharmacology & Therapeutics; Jul2017, Vol. 102 Issue 1, p45-51, 7p
Autor:
de Jong, FA (Floris), Marsh, S, Mathijssen, RHJ, King, C, Verweij, Jaap, Sparreboom, A, McLeod, HL
Publikováno v:
Clinical Cancer Research, 10(17), 5889-5894. American Association for Cancer Research Inc.
PURPOSE: The ATP-binding cassette transporter ABCG2 (breast cancer resistance protein) is an efflux protein that plays a role in host detoxification of various xenobiotic substrates, including the irinotecan metabolite 7- ethyl-10-hydroxycamptothecin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::5e622daba0b422fcc1d19194d06917d7
https://pure.eur.nl/en/publications/bae91787-d724-4bf6-8773-66cecfa51e01
https://pure.eur.nl/en/publications/bae91787-d724-4bf6-8773-66cecfa51e01
Autor:
Sparreboom, A, Gelderblom, AJ, Marsh, S, Ahluwalia, R, Obach, R, Principe, P, Twelves, C, Verweij, Jaap, McLeod, HL
Publikováno v:
Clinical Pharmacology & Therapeutics, 76, 38-44. Wiley-Blackwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::824501882a72d0f26f7da79e9876da33
https://pure.eur.nl/en/publications/df9c4e93-3d72-485f-b20b-9e2c4e3e5665
https://pure.eur.nl/en/publications/df9c4e93-3d72-485f-b20b-9e2c4e3e5665
Publikováno v:
Handbook of anticancer pharmacokinetics and pharmacodynamics 2004, 169-188
STARTPAGE=169;ENDPAGE=188;TITLE=Handbook of anticancer pharmacokinetics and pharmacodynamics 2004
STARTPAGE=169;ENDPAGE=188;TITLE=Handbook of anticancer pharmacokinetics and pharmacodynamics 2004
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::7d923abb9c58efd45f0a80b5a57b2ee0
https://pure.eur.nl/en/publications/fe53e43c-4352-4cfe-af07-b1c7178f5514
https://pure.eur.nl/en/publications/fe53e43c-4352-4cfe-af07-b1c7178f5514
Autor:
Hertz, DL, McLeod, HL
Publikováno v:
Clinical Pharmacology & Therapeutics; Feb2016, Vol. 99 Issue 2, p143-146, 4p