microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism.

Autor: Ismaeel A; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Peck BD; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Montgomery MM; Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, NC, USA., Burke BI; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Goh J; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Kang G; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Franco AB; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Mass Spectrometry and Proteomics Core, University of Kentucky, Lexington, KY, USA., Xia Q; Discipline of Physiology, School of Medicine, College of Medicine, Nursing, and Health Sciences, University of Galway, Galway, Ireland., Goljanek-Whysall K; Discipline of Physiology, School of Medicine, College of Medicine, Nursing, and Health Sciences, University of Galway, Galway, Ireland., McDonagh B; Discipline of Physiology, School of Medicine, College of Medicine, Nursing, and Health Sciences, University of Galway, Galway, Ireland., McLendon JM; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States., Koopmans PJ; Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.; Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR, USA., Jacko D; Institute of Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany.; Olympic Base Center, North Rhine-Westphalia/Rhineland, Cologne, Germany., Schaaf K; Institute of Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany.; Olympic Base Center, North Rhine-Westphalia/Rhineland, Cologne, Germany., Bloch W; Institute of Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany., Gehlert S; Institute of Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany.; Department for the Biosciences of Sports, Institute of Sports Science, University of Hildesheim, Hildesheim, Germany., Wen Y; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA., Murach KA; Department Health, Human Performance, & Recreation, University of Arkansas, Fayetteville, AR, USA.; Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR, USA., Peterson CA; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA., Boudreau RL; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Fisher-Wellman KH; Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, NC, USA., McCarthy JJ; Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA.; Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 10. Date of Electronic Publication: 2024 Aug 10.

Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity.

Autor: Berdaweel IA; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States.; Department of Clinical Pharmacy, College of Pharmacy, Yarmouk University, Irbid, Jordan., Monroe TB; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States., Alowaisi AA; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States.; Department of Clinical Pharmacy, College of Pharmacy, Yarmouk University, Irbid, Jordan., Mahoney JC; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States., Liang IC; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States., Berns KA; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States., Gao D; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States., McLendon JM; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.; Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Anderson EJ; Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States.; Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.; Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jan 03; Vol. 14, pp. 1275388. Date of Electronic Publication: 2024 Jan 03 (Print Publication: 2023).

Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.

Autor: McLendon JM; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA., Zhang X; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA., Matasic DS; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Department of Molecular Physiology and Biophysics University of Iowa Carver College of Medicine Iowa City IA., Kumar M; Department of Pharmacology and Systems Physiology University of Cincinnati OH.; Division of Cardiovascular Health and Disease Department of Internal Medicine Heart, Lung, and Vascular Institute University of Cincinnati OH., Koval OM; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA., Grumbach IM; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA., Sadayappan S; Department of Pharmacology and Systems Physiology University of Cincinnati OH.; Division of Cardiovascular Health and Disease Department of Internal Medicine Heart, Lung, and Vascular Institute University of Cincinnati OH., London B; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA., Boudreau RL; Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA.; Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2022 Jul 05; Vol. 11 (13), pp. e025687. Date of Electronic Publication: 2022 Jun 22.

Modulation of the cardiac sodium channel Na V 1.5 peak and late currents by NAD ⁺ precursors.

Autor: Matasic DS; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Yoon JY; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., McLendon JM; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Mehdi H; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Schmidt MS; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Greiner AM; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Quinones P; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Morgan GM; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Boudreau RL; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Irani K; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., Brenner C; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America., London B; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America. Electronic address: barry-london@uiowa.edu.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2020 Apr; Vol. 141, pp. 70-81. Date of Electronic Publication: 2020 Mar 21.

Aneurysm-type plexiform lesions form in supernumerary arteries in pulmonary arterial hypertension: potential therapeutic implications.

Autor: Oshima K; Department of Pharmacology, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama., Crockett ES; Department of Pharmacology, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama., Joshi SR; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama., McLendon JM; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama., Matsumoto Y; Department of Pharmacology, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama., McMurtry IF; Department of Pharmacology, University of South Alabama, Mobile, Alabama.; Department of Internal Medicine, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama., Abe K; Department of Advanced Cardiovascular Regulation and Therapeutics, Kyushu University, Fukuoka, Japan., Oka M; Department of Pharmacology, University of South Alabama, Mobile, Alabama.; Department of Internal Medicine, University of South Alabama, Mobile, Alabama.; Center for Lung Biology, University of South Alabama, Mobile, Alabama.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2019 Dec 01; Vol. 317 (6), pp. L805-L815. Date of Electronic Publication: 2019 Oct 02.