A high content imaging assay for identification of specific inhibitors of native Plasmodium liver stage protein synthesis.

Autor: McLellan JL; Department of Molecular Microbiology and Immunology, and the South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, USA., Morales-Hernandez B; Department of Molecular Microbiology and Immunology, and the South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, USA., Saeger S; Department of Molecular Microbiology and Immunology, and the South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, USA., Hanson KK; Department of Molecular Microbiology and Immunology, and the South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Oct 08; Vol. 68 (10), pp. e0079324. Date of Electronic Publication: 2024 Sep 10.

Differential effects of translation inhibitors on Plasmodium berghei liver stage parasites.

Autor: McLellan JL; https://ror.org/01kd65564 Department of Molecular Microbiology and Immunology and STCEID, University of Texas at San Antonio, San Antonio, TX, USA., Hanson KK; https://ror.org/01kd65564 Department of Molecular Microbiology and Immunology and STCEID, University of Texas at San Antonio, San Antonio, TX, USA kirsten.hanson@utsa.edu.

Publikováno v: Life science alliance [Life Sci Alliance] 2024 Apr 04; Vol. 7 (6). Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).

Antiplasmodial peptaibols act through membrane directed mechanisms.

Autor: Collins JE; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Lee JW; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA., Rocamora F; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Saggu GS; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA., Wendt KL; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Smick S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Santos NM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Paes R; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Jiang T; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Mittal N; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Luth MR; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chin T; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chang H; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., McLellan JL; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Morales-Hernandez B; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Hanson KK; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Desai SA; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA., Winzeler EA; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: ewinzeler@health.ucsd.edu., Cichewicz RH; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA. Electronic address: rhcichewicz@ou.edu., Chakrabarti D; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA. Electronic address: dchak@ucf.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Feb 15; Vol. 31 (2), pp. 312-325.e9. Date of Electronic Publication: 2023 Nov 22.

Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors.

Autor: McLellan JL; University of Texas at San Antonio, Department of Molecular Microbiology and Immunology and STCEID, San Antonio TX, USA., Hanson KK; University of Texas at San Antonio, Department of Molecular Microbiology and Immunology and STCEID, San Antonio TX, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 07. Date of Electronic Publication: 2023 Dec 07.

The Etiology of Childhood Pneumonia in The Gambia: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study.

Autor: Howie SRC; From the Medical Research Council Unit, Basse, The Gambia.; Department of Paediatrics, University of Auckland, New Zealand., Ebruke BE; From the Medical Research Council Unit, Basse, The Gambia., McLellan JL; From the Medical Research Council Unit, Basse, The Gambia.; The University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada., Deloria Knoll M; Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Dione MM; From the Medical Research Council Unit, Basse, The Gambia.; International Livestock Research Institute, Kampala, Uganda., Feikin DR; Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Haddix M; Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Hammitt LL; Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Machuka EM; From the Medical Research Council Unit, Basse, The Gambia., Murdoch DR; Department of Pathology, University of Otago, Christchurch, New Zealand.; Microbiology Unit, Canterbury Health Laboratories, Christchurch, New Zealand., O'Brien KL; Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Ofordile O; From the Medical Research Council Unit, Basse, The Gambia., Olutunde OE; From the Medical Research Council Unit, Basse, The Gambia., Parker D; From the Medical Research Council Unit, Basse, The Gambia.; AstraZeneca, Cambridge, United Kingdom., Prosperi C; Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Salaudeen RA; From the Medical Research Council Unit, Basse, The Gambia.; Medical Microbiology Department, Lagos University Teaching Hospital, Lagos, Nigeria., Shamsul A; From the Medical Research Council Unit, Basse, The Gambia., Mackenzie G; From the Medical Research Council Unit, Basse, The Gambia.; Murdoch Children's Research Institute, Melbourne, Australia.; London School of Hygiene & Tropical Medicine., Antonio M; From the Medical Research Council Unit, Basse, The Gambia.; Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine.; Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom., Zaman SMA; From the Medical Research Council Unit, Basse, The Gambia.; London School of Hygiene & Tropical Medicine.

Publikováno v: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2021 Sep 01; Vol. 40 (9S), pp. S7-S17.