Zobrazeno 1 - 10
of 251
pro vyhledávání: '"McLean, Samantha"'
Autor:
Jameson, Adam, Tomlinson, Justine, Medlinskiene, Kristina, Dane, Howard, Saeed, Imran, Sohal, J., Dalton, C., Sagoo, G.S., Cardno, A., Bristow, Greg C., Fylan, Beth, McLean, Samantha
Yes
Pharmacogenomic (PGx) testing can help personalise psychiatric prescribing and improve on the currently adopted trial-and-error prescribing approach. However, widespread implementation is yet to occur. Understanding factors influencing imple
Pharmacogenomic (PGx) testing can help personalise psychiatric prescribing and improve on the currently adopted trial-and-error prescribing approach. However, widespread implementation is yet to occur. Understanding factors influencing imple
Externí odkaz:
http://hdl.handle.net/10454/20036
Yes
Background: Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing recommendations may far exceed the necessary degree of dopamine D
Background: Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing recommendations may far exceed the necessary degree of dopamine D
Externí odkaz:
http://hdl.handle.net/10454/19916
Autor:
Jameson, Adam, Faisal, Muhammad, Fylan, Beth, Bristow, Greg C., Sohal, J., Dalton, C., Sagoo, G.S., Cardno, A.G., McLean, Samantha
Yes
Background: Prescribing drugs for psychosis (antipsychotics) is challenging due to high rates of poor treatment outcomes, which are in part explained by an individual’s genetics. Pharmacogenomic (PGx) testing can help clinicians tailor the
Background: Prescribing drugs for psychosis (antipsychotics) is challenging due to high rates of poor treatment outcomes, which are in part explained by an individual’s genetics. Pharmacogenomic (PGx) testing can help clinicians tailor the
Externí odkaz:
http://hdl.handle.net/10454/19915
Autor:
Jameson, A., Fylan, Beth, Bristow, Greg C., Cardno, A., Dalton, C., Sagoo, G., Sohal, J., McLean, Samantha
Yes
Patients' pharmacogenetic data could be used to improve adherence to antipsychotic medication by increasing the likelihood of therapeutic response and reducing the prevalence of adverse drug reactions.
Patients' pharmacogenetic data could be used to improve adherence to antipsychotic medication by increasing the likelihood of therapeutic response and reducing the prevalence of adverse drug reactions.
Externí odkaz:
http://hdl.handle.net/10454/19587
Autor:
Yun, Haesung, Dumbell, R., Hanna, Katie, Bowen, Junior, McLean, Samantha, Kantamneni, Sriharsha, Pors, Klaus, Wu, Q-F, Helfer, Gisela
Yes
Chemerin is an adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism, and has been hypothesized as a link between obesity and type II diabetes. In humans affected by obesity, chemerin gene expression in periphe
Chemerin is an adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism, and has been hypothesized as a link between obesity and type II diabetes. In humans affected by obesity, chemerin gene expression in periphe
Externí odkaz:
http://hdl.handle.net/10454/18995
Yes
In many species, seasonal changes in day length (photoperiod) have profound effects on physiology and behavior. In humans, these include cognitive function and mood. Here we investigated the effect of photoperiod and high fat diets on cognit
In many species, seasonal changes in day length (photoperiod) have profound effects on physiology and behavior. In humans, these include cognitive function and mood. Here we investigated the effect of photoperiod and high fat diets on cognit
Externí odkaz:
http://hdl.handle.net/10454/18550
Autor:
Jameson, Adam, Fylan, Beth, Bristow, Greg C., Sagoo, G.S., Dalton, C., Cardno, A., Sohal, J., McLean, Samantha L.
Yes
In psychiatry, the selection of antipsychotics and antidepressants is generally led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). T
In psychiatry, the selection of antipsychotics and antidepressants is generally led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). T
Externí odkaz:
http://hdl.handle.net/10454/18618
Autor:
Hjorth, S., Waters, S., Waters, N., Tedroff, J., Svensson, P., Fagerberg, A., Edling, M., Svanberg, B., Ljung, E., Gunnergren, J., McLean, Samantha L., Grayson, B., Idris, N.F., Neill, J.C., Sonesson, C.
Yes
Here we describe for the first time the distinctive pharmacological profile for IRL752, a new phenyl-pyrrolidine derivative with regio-selective CNS transmission-enhancing properties. IRL752 (3.7-150 μmol/kg, s.c.) was characterised through
Here we describe for the first time the distinctive pharmacological profile for IRL752, a new phenyl-pyrrolidine derivative with regio-selective CNS transmission-enhancing properties. IRL752 (3.7-150 μmol/kg, s.c.) was characterised through
Externí odkaz:
http://hdl.handle.net/10454/17970
Autor:
Watremez, W., Jackson, J., Almari, B., McLean, Samantha, Grayson, B., Neilla, J.C., Fischer, N., Allouche, A., Koziel, V., Pillot, T., Harte, M.K.
Yes
Background:With current treatments for Alzheimer’s disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD
Background:With current treatments for Alzheimer’s disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD
Externí odkaz:
http://hdl.handle.net/10454/15087
Yes
Rationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly val
Rationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly val
Externí odkaz:
http://hdl.handle.net/10454/11616