Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

Autor: Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)

Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells. Chimeric antigen receptor (CAR) therapy involves genetic engineering to ‘redirect’

Externí odkaz: https://doaj.org/article/fd472df9a6d743fab850b3a2c42e8947

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

Autor: Paolo D. A. Vignali, Kristin DePeaux, McLane J. Watson, Chenxian Ye, B. Rhodes Ford, Konstantinos Lontos, Nicole K. McGaa, Nicole E. Scharping, Ashley V. Menk, Simon C. Robson, Amanda C. Poholek, Dayana B. Rivadeneira, Greg M. Delgoffe

Publikováno v: Nature Immunology. 24:267-279

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5b04dd1f0b003240dcd0422a4fb8079
https://doi.org/10.1038/s41590-022-01379-9

PYGBacking on glycogen metabolism to fuel early memory T cell recall responses

Autor: Joseph Longo, McLane J. Watson, Matthew J. Vos, Kelsey S. Williams, Russell G. Jones

Publikováno v: Molecular cell. 82(16)

Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8291b034b406348dc031e728b2da8cf8
https://pubmed.ncbi.nlm.nih.gov/35738262

Carbon source availability drives nutrient utilization in CD8+ T cells

Autor: Irem Kaymak, Katarzyna M. Luda, Lauren R. Duimstra, Eric H. Ma, Joseph Longo, Michael S. Dahabieh, Brandon Faubert, Brandon M. Oswald, McLane J. Watson, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Shelby E. Compton, Zhen Fu, Ralph J. DeBerardinis, Kelsey S. Williams, Ryan D. Sheldon, Russell G. Jones

Publikováno v: Kaymak, I, Luda, K M, Duimstra, L R, Ma, E H, Longo, J, Dahabieh, M S, Faubert, B, Oswald, B M, Watson, M J, Kitchen-Goosen, S M, DeCamp, L M, Compton, S E, Fu, Z, DeBerardinis, R J, Williams, K S, Sheldon, R D & Jones, R G 2022, ' Carbon source availability drives nutrient utilization in CD8 + T cells ', Cell Metabolism, vol. 34, no. 9, pp. 1298-1311 . https://doi.org/10.1016/j.cmet.2022.07.012

How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts glucose utilization by CD8+ T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc662475884cf35455d28e170d3f4784
https://curis.ku.dk/portal/da/publications/carbon-source-availability-drives-nutrient-utilization-in-cd8-tcells(cfed88a3-de14-457b-91f9-907610f2f792).html

CTLA-4 blockade drives loss of T

Autor: Roberta, Zappasodi, Inna, Serganova, Ivan J, Cohen, Masatomo, Maeda, Masahiro, Shindo, Yasin, Senbabaoglu, McLane J, Watson, Avigdor, Leftin, Rachana, Maniyar, Svena, Verma, Matthew, Lubin, Myat, Ko, Mayuresh M, Mane, Hong, Zhong, Cailian, Liu, Arnab, Ghosh, Mohsen, Abu-Akeel, Ellen, Ackerstaff, Jason A, Koutcher, Ping-Chih, Ho, Greg M, Delgoffe, Ronald, Blasberg, Jedd D, Wolchok, Taha, Merghoub

Publikováno v: Nature. 591(7851)

Limiting metabolic competition in the tumour microenvironment may increase the effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of activated T cells, CD28 signalling has been proposed as a metabolic biosensor of T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f796e15f3fb8c1fff677e1a7a16adc8
https://pubmed.ncbi.nlm.nih.gov/34013589