mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA.

Autor: Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo

Publikováno v: PLoS Pathogens, Vol 20, Iss 7, p e1012345 (2024)

The CRISPR-Cas13 system has been proposed as an alternative treatment of viral infections. However, for this approach to be adopted as an antiviral, it must be optimized until levels of efficacy rival or exceed the performance of conventional approac

Externí odkaz: https://doaj.org/article/ff2b71e5f2c14cc889ed30f7de84cd2e

Supplementary Figure from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing

Autor: Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham

Supplementary Figure from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f74e0f528f0b44e595a4a686d003dd6
https://doi.org/10.1158/1541-7786.22528140

Data from Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing

Autor: Srinivasan Yegnasubramanian, William G. Nelson, Sarah J. Wheelan, William B. Isaacs, Christina DeStefano Shields, Jianfeng Xu, S. Lilly Zheng, Michael C. Haffner, Jonathan B. Coulter, McKinzie A. Garrison, Alyza Skaist, Ajay Vaghasia, Harshath Gupta, Anuj Gupta, Minh-Tam Pham

A limited number of cell lines have fueled the majority of preclinical prostate cancer research, but their genomes remain incompletely characterized. Here, we utilized whole-genome linked-read sequencing for comprehensive characterization of phased m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b27371dbf32222e2f7eb6c3686846b7
https://doi.org/10.1158/1541-7786.c.6545628.v1

Abstract 2198: Allelic phasing of genomic alterations through linked read whole genome sequencing in human prostate cancer cell lines

Autor: Ajay Vaghasia, Srinivasan Yegnasubramanian, Alyza M. Skaist, Roshan Chikamarne, Anuj Gupta, Harshath Gupta, McKinzie A. Garrison, Sarah J. Wheelan, Minh-Tam Pham, William G. Nelson

Publikováno v: Cancer Research. 81:2198-2198

Prostate cancer research has relied on a limited number of prostate cancer cell lines despite decades of effort in establishing them from human prostate cancers. These cell lines thus represent precious resources for in vitro and in vivo preclinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60ead56d7afc7c7be60727a503386b1f
https://doi.org/10.1158/1538-7445.am2021-2198

mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA.

Autor: Chaves, Lorena C. S.¹ (AUTHOR), Orr-Burks, Nichole² (AUTHOR), Vanover, Daryll¹ (AUTHOR), Mosur, Varun V.¹ (AUTHOR), Hosking, Sarah R.² (AUTHOR), Kumar E. K., Pramod¹ (AUTHOR), Jeong, Hyeyoon¹ (AUTHOR), Jung, Younghun¹ (AUTHOR), Assumpção, José A. F.¹ (AUTHOR), Peck, Hannah E.¹ (AUTHOR), Nelson, Sarah L.³ (AUTHOR), Burke, Kaitlyn N.³ (AUTHOR), Garrison, McKinzie A.⁴ (AUTHOR), Arthur, Robert A.⁴ (AUTHOR), Claussen, Henry⁴ (AUTHOR), Heaton, Nicholas S.^3,5 (AUTHOR), Lafontaine, Eric R.² (AUTHOR), Hogan, Robert J.² (AUTHOR), Zurla, Chiara¹ (AUTHOR) chiara.zurla@emory.edu, Santangelo, Philip J.¹ (AUTHOR) chiara.zurla@emory.edu

Publikováno v: PLoS Pathogens. 7/5/2024, Vol. 20 Issue 7, p1-27. 27p.