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Analysis of the B cell receptor repertoire in six immune-mediated diseases

Autor: Bashford-Rogers, RJM, Bergamaschi, L, McKinney, EF, Pombal, DC, Mescia, F, Lee, JC, Thomas, DC, Flint, SM, Kellam, P, Jayne, DRW, Lyons, PA, Smith, KGC

B cells are important in the pathogenesis of many, and perhaps all, immune-mediated diseases. Each B cell expresses a single B cell receptor (BCR)1, and the diverse range of BCRs expressed by the total B cell population of an individual is termed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e8ac346b61fb117e4595155c27ea608

Looking back at the TEDDY study: lessons and future directions.

Autor: Lernmark Å; Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Malmö, Sweden. ake.lernmark@med.lu.se., Agardh D; Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Malmö, Sweden., Akolkar B; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Gesualdo P; Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO, USA., Hagopian WA; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Haller MJ; Department of Pediatrics, University of Florida, Gainesville, FL, USA., Hyöty H; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Johnson SB; Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, FL, USA., Elding Larsson H; Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Malmö, Sweden., Liu E; Digestive Health Institute, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lynch KF; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., McKinney EF; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., McIndoe R; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA., Melin J; Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Malmö, Sweden., Norris JM; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rewers M; Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Toppari J; Department of Paediatrics, Turku University Hospital, Turku, Finland.; Institute of Biomedicine, Research Centre for Integrated Physiology and Pharmacology, University of Turku, Turku, Finland., Triplett E; University of Florida, Department of Microbiology and Cell Science, Gainesville, FL, USA., Vehik K; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Virtanen SM; Center for Child Health Research, Tampere University and University Hospital and Research, Tampere, Finland., Ziegler AG; Institute of Diabetes Research, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Munich, Germany.; Forschergruppe Diabetes e.V. at Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Munich, Germany.; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München and e.V., Munich, Germany., Schatz DA; Department of Pediatrics, University of Florida, Gainesville, FL, USA., Krischer J; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Publikováno v: Nature reviews. Endocrinology [Nat Rev Endocrinol] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial.

Autor: Noor NM; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lee JC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK; Department of Gastroenterology, UCL Institute of Liver and Digestive Diseases, Royal Free Hospital, London, UK., Bond S; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK., Dowling F; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Brezina B; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Patel KV; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK., Ahmad T; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Banim PJ; Department of Gastroenterology, James Paget University Hospital, Great Yarmouth, UK., Berrill JW; Department of Gastroenterology, Royal Glamorgan Hospital, Llantrisant, UK., Cooney R; GI Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., De La Revilla Negro J; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., de Silva S; Department of Gastroenterology, The Dudley Group NHS Foundation Trust, Dudley, UK., Din S; Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK., Durai D; Department of Gastroenterology, Cardiff and Vale University Health Board, University Hospital of Wales, Cardiff, UK., Gordon JN; Department of Gastroenterology, Royal Hampshire County Hospital, Winchester, UK., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Johnson M; Gastroenterology Department, Luton and Dunstable University Hospital, Luton, UK., Kent AJ; Department of Gastroenterology, King's College Hospital NHS Foundation Trust, London, UK., Kok KB; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, UK., Moran GW; National Institute of Health Research Nottingham Biomedical Research Centre, University of Nottingham and Nottingham University Hospitals, Nottingham, UK., Mowat C; Department of Gastroenterology, Ninewells Hospital, Dundee, Scotland, UK., Patel P; Department of Gastroenterology, Epsom and St Helier University Hospitals, Carshalton, UK., Probert CS; Department of Gastroenterology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Raine T; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Saich R; Department of Gastroenterology, Basingstoke and North Hampshire Hospital, Basingstoke, UK., Seward A; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK., Sharpstone D; Department of Gastroenterology, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK., Smith MA; Department of Gastroenterology, University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Subramanian S; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wiles A; Department of Gastroenterology, The Queen Elizabeth Hospital King's Lynn NHS Trust, King's Lynn, UK., Williams HRT; Department of Gastroenterology, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK., van den Brink GR; Roche Innovation Center Basel, Roche, Basel, Basel-Stadt, Switzerland., Vermeire S; Department of Gastroenterology and Hepatology, Department of Chronic Diseases and Metabolism, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Jairath V; Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada., D'Haens GR; Department of Gastroenterology, Amsterdam University Medical Center, Amsterdam, Netherlands., McKinney EF; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; PredictImmune Ltd, Babraham Research Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Lyons PA; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; PredictImmune Ltd, Babraham Research Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Lindsay JO; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, UK., Kennedy NA; Department of Gastroenterology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Smith KGC; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK; PredictImmune Ltd, Babraham Research Campus, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Parkes M; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK. Electronic address: mp372@cam.ac.uk.

Publikováno v: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2024 May; Vol. 9 (5), pp. 415-427. Date of Electronic Publication: 2024 Feb 22.

Autoimmunity Is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension.

Autor: Jones RJ; Heart and Lung Research Institute., De Bie EMDD; Heart and Lung Research Institute., Groves E; Heart and Lung Research Institute., Zalewska KI; Heart and Lung Research Institute.; Royal Papworth Hospital, and., Swietlik EM; Heart and Lung Research Institute.; Royal Papworth Hospital, and., Treacy CM; Heart and Lung Research Institute., Martin JM; Heart and Lung Research Institute., Polwarth G; Royal Papworth Hospital, and., Li W; Heart and Lung Research Institute., Guo J; Heart and Lung Research Institute., Baxendale HE; Royal Papworth Hospital, and., Coleman S; Medical Research Council Biostatistics Unit., Savinykh N; Cambridge Biomedical Research Centre Phenotyping Hub, Department of Medicine, University of Cambridge., Coghlan JG; Royal Free London National Health Service Foundation Trust, London, United Kingdom., Corris PA; Freeman Hospital, Newcastle-upon-Tyne, United Kingdom., Howard LS; Hammersmith Hospital, London, United Kingdom., Johnson MK; Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom., Church C; Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom., Kiely DG; Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom., Lawrie A; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom., Lordan JL; Freeman Hospital, Newcastle-upon-Tyne, United Kingdom., Mackenzie Ross RV; Royal United Hospitals Bath National Health Service Foundation Trust, Bath, United Kingdom., Pepke Zaba J; Royal Papworth Hospital, and., Wilkins MR; National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom., Wort SJ; Royal Brompton Hospital, London, United Kingdom., Fiorillo E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy., Orrù V; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy., Cucca F; University of Sassari, Sassari, Italy; and., Rhodes CJ; National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom., Gräf S; Heart and Lung Research Institute., Morrell NW; Heart and Lung Research Institute., McKinney EF; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Wallace C; Heart and Lung Research Institute.; Medical Research Council Biostatistics Unit.; Department of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, United Kingdom., Toshner M; Heart and Lung Research Institute.; Royal Papworth Hospital, and.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2022 Jul 01; Vol. 206 (1), pp. 81-93.