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Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni - 'The Undiscovered Country'

Autor: McKerrow, James, Horn, M, Fajtová, P, Rojo, L, Ulrychová, L, Bartošová-Sojková, P, Franta, Z, Protasio, AV, Opavský, D, Vondrášek, J, McKerrow, JH

Publikováno v: McKerrow, James; Horn, M; Fajtová, P; Rojo, L; Ulrychová, L; Bartošová-Sojková, P; et al.(2014). Trypsin-and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni-'The Undiscovered Country'. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/819014zx

Background:Blood flukes (Schistosoma spp.) are parasites that can survive for years or decades in the vasculature of permissive mammalian hosts, including humans. Proteolytic enzymes (proteases) are crucial for successful parasitism, including aspect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e93ce15924daa2e918edc10489417e4f
http://www.escholarship.org/uc/item/819014zx

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A Global Comparison of the Human and T. brucei Degradomes Gives Insights about Possible Parasite Drug Targets

Autor: McKerrow, James, Babbitt, Patricia, Mashiyama, ST, Koupparis, K, Caffrey, CR, McKerrow, JH, Babbitt, PC

Publikováno v: McKerrow, James; Babbitt, Patricia; Mashiyama, ST; Koupparis, K; Caffrey, CR; McKerrow, JH; et al.(2012). A Global Comparison of the Human and T. brucei Degradomes Gives Insights about Possible Parasite Drug Targets. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7br8t1w8

We performed a genome-level computational study of sequence and structure similarity, the latter using crystal structures and models, of the proteases of Homo sapiens and the human parasite Trypanosoma brucei. Using sequence and structure similarity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7f049513d8199139632df3b424e688de
http://www.escholarship.org/uc/item/7br8t1w8

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Hit-to-Lead Development of the Chamigrane Endoperoxide Merulin A for the Treatment of African Sleeping Sickness

Autor: McKerrow, James, Navarro, G, Chokpaiboon, S, de, G, Bray, WM, Nisam, SC, McKerrow, JH, Pudhom, K, Linington, RG

Publikováno v: McKerrow, James; Navarro, G; Chokpaiboon, S; de, G; Bray, WM; Nisam, SC; et al.(2012). Hit-to-Lead Development of the Chamigrane Endoperoxide Merulin A for the Treatment of African Sleeping Sickness. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2p3678fs

Background: Human African trypanosomiasis (HAT) is an infectious disease with a large global health burden occurring primarily in Central and Eastern Africa. Most current treatments have poor blood brain barrier (BBB) penetration, which prevent them

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::85061bf24e75339380248066a633afc2
http://www.escholarship.org/uc/item/2p3678fs

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Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Autor: McKerrow, James, Leung, Jacqueline, McCune, Joseph, Broadhurst, MJ, Leung, JM, Lim, KC, Girgis, NM, Gundra, UM, Fallon, PG, Premenko-Lanier, M, McKerrow, JH, McCune, JM, Loke, P

Publikováno v: McKerrow, James; Leung, Jacqueline; McCune, Joseph; Broadhurst, MJ; Leung, JM; Lim, KC; et al.(2012). Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0zt3x35b

Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::edc174bae3356289e37046c4c1a8c9d6
http://www.escholarship.org/uc/item/0zt3x35b

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Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis

Autor: Rascón Aa, McKerrow Jh

Publikováno v: Current medicinal chemistry. 20(25)

Protease function is essential to many biological systems and processes. In parasites, proteases are essential for host tissue degradation, immune evasion, and nutrition acquisition. Helminths (worms) depend on several classes of proteases for develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211e5f6758aca530b323b35686176c92
https://pubmed.ncbi.nlm.nih.gov/23514418

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Cytokine induction and exploitation in schistosome infections

Autor: McKerrow Jh

Publikováno v: Parasitology.

Schistosome parasites, despite being multicellular organisms several millimetres in length, can survive in the bloodstream of mammalian hosts for decades. The remarkable and complex adaptation exemplified in the host–parasite relationship in schist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb05e247eb9c28382c6c1efcc46dded
https://pubmed.ncbi.nlm.nih.gov/9571696

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