pH and proton sensor GPR65 determine susceptibility to atopic dermatitis

Autor: Xie, L, McKenzie, CI, Qu, X, Mu, Y, Wang, Q, Bing, N, Naidoo, K, Alam, MJ, Yu, D, Gong, F, Ang, C, Robert, R, Marques, FZ, Furlotte, N, Hinds, D, Gasser, O, Xavier, RJ, MacKay, CR, Agee, M, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Huber, KE, Kleinman, A, Litterman, NK, McCreight, JC, McIntyre, MH, Mountain, JL, Noblin, ES, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Tung, JY, Vacic, V

Publikováno v: J Immunol

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8163a852dd3533323240cee7327c2f6
https://doi.org/10.4049/jimmunol.2001363

Conversion of vaccines from low to high immunogenicity by antibodies with epitope complementarity.

Autor: Dvorscek AR; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., McKenzie CI; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Stäheli VC; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Ding Z; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., White J; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia., Fabb SA; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Lim L; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., O'Donnell K; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Pitt C; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Christ D; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia., Hill DL; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Pouton CW; Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia., Burnett DL; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2010, Australia., Brink R; Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia., Robinson MJ; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Tarlinton DM; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Quast I; Department of Immunology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: isaak.quast@monash.edu.

Publikováno v: Immunity [Immunity] 2024 Oct 08; Vol. 57 (10), pp. 2433-2452.e7. Date of Electronic Publication: 2024 Sep 20.

Subcutaneous immunotherapy for bee venom allergy induces epitope spreading and immunophenotypic changes in allergen-specific memory B cells.

Autor: McKenzie CI; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia., Reinwald S; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Australia., Averso B; EVQLV, New York, NY., Spurrier B; EVQLV, New York, NY., Satz A; EVQLV, New York, NY., von Borstel A; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia., Masinovic S; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia., Varese N; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Australia; Immune Therapies Group, Burnet Institute, Melbourne, Australia., Aui PM; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia., Wines BD; Immune Therapies Group, Burnet Institute, Melbourne, Australia., Hogarth PM; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia; Immune Therapies Group, Burnet Institute, Melbourne, Australia; Department of Pathology, The University of Melbourne, Parkville, Australia., Hew M; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Rolland JM; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Australia., O'Hehir RE; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Australia., van Zelm MC; Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Australia; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Australia; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: m.vanzelm@erasmusmc.nl.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Aug 30. Date of Electronic Publication: 2024 Aug 30.

RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect.

Autor: McKenzie CI; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Varese N; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Aui PM; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Reinwald S; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Wines BD; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia.; Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia., Hogarth PM; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia.; Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia., Thien F; Respiratory Medicine, Eastern Health, Box Hill and Monash University, Melbourne, Victoria, Australia., Hew M; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia., Rolland JM; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia., O'Hehir RE; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Department of Allergy, Immunology and Respiratory Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia., van Zelm MC; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Allergy, Asthma and Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia.

Publikováno v: Allergy [Allergy] 2023 Mar; Vol. 78 (3), pp. 822-835. Date of Electronic Publication: 2022 Oct 01.

Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells.

Autor: Quast I; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: isaak.quast@monash.edu., Dvorscek AR; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Pattaroni C; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Steiner TM; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, VIC 3000, Australia., McKenzie CI; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Pitt C; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., O'Donnell K; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Ding Z; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Hill DL; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Brink R; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, UNSW Sydney, Sydney, NSW 2010, Australia., Robinson MJ; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Zotos D; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia., Tarlinton DM; Department of Immunology and Pathology, Monash University, 89 Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: david.tarlinton@monash.edu.

Publikováno v: Immunity [Immunity] 2022 Aug 09; Vol. 55 (8), pp. 1414-1430.e5. Date of Electronic Publication: 2022 Jul 26.