Výsledky vyhledávání - "McKay W, Easton"

Exploring the Reaction Mechanisms of Fast Pyrolysis of Xylan Model Compounds via Tandem Mass Spectrometry and Quantum Chemical Calculations

Autor: Hanyu Zhu, Fabio H. Ribeiro, Lan Xu, W. Nicholas Delgass, John C. Degenstein, Rakesh Agrawal, Mckay W Easton, Priya Murria, Hilkka I. Kenttämaa, Zaikuan Yu

Publikováno v: The Journal of Physical Chemistry A. 123:9149-9157

A commercial fast pyrolysis probe coupled with a high-resolution tandem mass spectrometer was employed to identify the initial reactions and products of fast pyrolysis of xylobiose and xylotriose, model compounds of xylans. Fragmentation of the reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ac5d2919defab2c6eb2905598ffc55
https://doi.org/10.1021/acs.jpca.9b04438

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Identification of Protonated Primary Carbamates by Using Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments

Autor: Leah F. Easterling, Mckay W Easton, Hilkka I. Kenttämaa, Zhoupeng Zhang, John Kong, Judy Liu, Zaikuan Yu, Jacob Milton, Huaming Sheng, Edouard Niyonsaba

Publikováno v: Organic Process Research & Development. 23:1159-1166

The levels of potentially mutagenic impurities (PMIs) in active pharmaceutical ingredients are highly regulated and must be below a critical safety threshold. One class of PMIs is primary carbamates, which are formed during drug manufacturing and for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63f8a3d3f612292174f715b77520a33c
https://doi.org/10.1021/acs.oprd.9b00080

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Molecular-Level Understanding of the Major Fragmentation Mechanisms of Cellulose Fast Pyrolysis: An Experimental Approach Based on Isotopically Labeled Model Compounds

Autor: Hilkka I. Kenttämaa, Duanchen Ding, Lan Xu, Priya Murria, Zaikuan J Yu, Mckay W Easton, Jifa Zhang, Yuan Jiang

Publikováno v: The Journal of Organic Chemistry. 84:7037-7050

Evaluation of the feasibility of various mechanisms possibly involved in cellulose fast pyrolysis is challenging. Therefore, selectively 13C-labeled cellotriose, 18O-labeled cellobiose, and 13C- and 18O-doubly-labeled cellobiose were synthesized and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86ab0dc118750348b3132e74dc7605a
https://doi.org/10.1021/acs.joc.9b00723

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Distinguishing Isomeric Aromatic Radical Cations by Using Energy-Resolved Ion Trap and Medium Energy Collision-Activated Dissociation Mass Spectrometry

Autor: Mark Romanczyk, Yuyang Zhang, Mckay W Easton, Wanru Li, Jyrki Viidanoja, Hilkka I. Kenttämaa

Publikováno v: Journal of the American Society for Mass Spectrometry. 31(1)

Different collision-activated dissociation (CAD) methods were evaluated for their effectiveness at distinguishing several ionized isomeric aromatic compounds by using a linear quadrupole ion trap/orbitrap mass spectrometer. The compounds were ionized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e86cb3036d3aac3d90e8e579865e1d
https://pubmed.ncbi.nlm.nih.gov/32881507

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Identification of the carboxylic acid functionality in protonated drug metabolite model compounds by using tandem mass spectrometry based on ion-molecule reactions coupled with high performance liquid chromatography

Autor: Xin Ma, Xueming Dong, Kawthar Z. Alzarieni, Hilkka I. Kenttämaa, Mckay W Easton, Jacob Milton, Chungang Gu, Joann P. Max

Publikováno v: International Journal of Mass Spectrometry. 463:116551

The carboxylic acid functionality is among the many functionalities that drug metabolites, degradation products and impurities may contain. Therefore, analytical techniques that can be used to rapidly identify the carboxylic acid functionality are im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43f4b234dfa92787627331ed190bd8c2
https://doi.org/10.1016/j.ijms.2021.116551

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Differentiating Isomeric Deprotonated Glucuronide Drug Metabolites via Ion/Molecule Reactions in Tandem Mass Spectrometry

Autor: Mckay W Easton, Hilkka I. Kenttämaa, John Kong, Edouard Niyonsaba, Zhoupeng Zhang, Arun K. Ghosh, Zaikuan Yu, Tiffany M. Jarrell, Huaming Sheng, Xin Ma, Ravikiran Yerabolu

Publikováno v: Analytical chemistry. 90(15)

Isomeric O- and N-glucuronides are common drug metabolites produced in phase II of drug metabolism. Distinguishing these isomers by using common analytical techniques has proven challenging. A tandem mass spectrometric method based on gas-phase ion/m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1332b271ee811ad94bdce4947eae13d
https://pubmed.ncbi.nlm.nih.gov/29984992

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Mass Spectrometric Studies of Fast Pyrolysis of Cellulose

Autor: Mark S. Carlsen, James S. Riedeman, Hilkka I. Kenttämaa, Mckay W Easton, John C. Degenstein, Fabio H. Ribeiro, Harshavardhan Choudhari, Rakesh Agrawal, John J. Nash, Priya Murria, Linan Yang, Matthew R. Hurt, W. Nicholas Delgass

Publikováno v: European Journal of Mass Spectrometry. 21:321-326

A fast pyrolysis probe/linear quadrupole ion trap mass spectrometer combination was used to study the primary fast pyrolysis products (those that first leave the hot pyrolysis surface) of cellulose, cellobiose, cellotriose, cellotetraose, cellopentao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476cfe4ee3417447457f090f6ba0d31f
https://doi.org/10.1255/ejms.1335

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Identification of Protonated Sulfone and Aromatic Carboxylic Acid Functionalities in Organic Molecules by Using Ion-Molecule Reactions Followed by Collisionally Activated Dissociation in a Linear Quadrupole Ion Trap Mass Spectrometer

Autor: Raghavendhar R. Kotha, Minli Zhang, John Kong, Chungang Gu, Joann P. Max, Huaming Sheng, Hilkka I. Kenttämaa, Ravikiran Yerabolu, Mckay W Easton

Publikováno v: Analytical chemistry. 89(14)

Gas-phase reactivity of protonated model compounds with different functional groups toward trimethoxymethylsilane (TMMS) was studied to explore the utility of this reagent in mass spectrometric identification of specific functionalities for potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3924bbdd817d0f33beec5373709e4c
https://pubmed.ncbi.nlm.nih.gov/28621918

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