pH and proton sensor GPR65 determine susceptibility to atopic dermatitis

Autor: Xie, L, McKenzie, CI, Qu, X, Mu, Y, Wang, Q, Bing, N, Naidoo, K, Alam, MJ, Yu, D, Gong, F, Ang, C, Robert, R, Marques, FZ, Furlotte, N, Hinds, D, Gasser, O, Xavier, RJ, MacKay, CR, Agee, M, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Huber, KE, Kleinman, A, Litterman, NK, McCreight, JC, McIntyre, MH, Mountain, JL, Noblin, ES, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Tung, JY, Vacic, V

Publikováno v: J Immunol

pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association study and report that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8163a852dd3533323240cee7327c2f6
https://doi.org/10.4049/jimmunol.2001363

An atlas of genetic influences on osteoporosis in humans and mice

Autor: Morris, JA, Kemp, JP, Youlten, SE, Laurent, L, Logan, JG, Chai, RC, Vulpescu, NA, Forgetta, V, Kleinman, A, Mohanty, ST, Sergio, CM, Quinn, J, Nguyen-Yamamoto, L, Luco, A-L, Vijay, J, Simon, M-M, Pramatarova, A, Medina-Gomez, C, Trajanoska, K, Ghirardello, EJ, Butterfield, NC, Curry, KF, Leitch, VD, Sparkes, PC, Adoum, A-T, Mannan, NS, Komla-Ebri, DSK, Pollard, AS, Dewhurst, HF, Hassall, TAD, Beltejar, M-JG, Agee, M, Alipanahi, B, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Furlotte, NA, McCreight, JC, Huber, KE, Litterman, NK, McIntyre, MH, Mountain, JL, Noblin, ES, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Tung, JY, Vacic, V, Wilson, CH, Adams, DJ, Vaillancourt, SM, Kaptoge, S, Baldock, P, Cooper, C, Reeve, J, Ntzani, EE, Evangelou, E, Ohlsson, C, Karasik, D, Rivadeneira, F, Kiel, DP, Tobias, JH, Gregson, CL, Harvey, NC, Grundberg, E, Goltzman, D, Lelliott, CJ, Hinds, DA, Ackert-Bicknell, CL, Hsu, Y-H, Maurano, MT, Croucher, PI, Williams, GR, Bassett, JHD, Evans, DM, Richards, JB

Publikováno v: Nature Genetics, 51(2), 258-266. Nature Publishing Group
the 23 and Me Research Team, Morris, J A, Kemp, J P, Youlten, S E, Laurent, L, Logan, J G, Chai, R C, Vulpescu, N A, Forgetta, V, Kleinman, A, Mohanty, S T, Sergio, C M, Quinn, J, Nguyen-Yamamoto, L, Luco, A L, Vijay, J, Simon, M M, Pramatarova, A, Medina-Gomez, C, Trajanoska, K, Ghirardello, E J, Butterfield, N C, Curry, K F, Leitch, V D, Sparkes, P C, Adoum, A T, Mannan, N S, Komla-Ebri, D S K, Pollard, A S, Dewhurst, H F, Hassall, T A D, Beltejar, M J G, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, McCreight, J C, Huber, K E, Litterman, N K, McIntyre, M H, Mountain, J L, Wilson, C H, Cooper, C, Tobias, J H, Gregson, C L, Adams, D J & Evans, D M 2019, ' An atlas of genetic influences on osteoporosis in humans and mice ', Nature Genetics, vol. 51, pp. 258–266 . https://doi.org/10.1038/s41588-018-0302-x
Nature genetics

Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone mineral density (BMD). We undertook a comprehensive assessment of human genetic determinants of bone density in 426,824 individuals, identifying a total of 518 genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144c7600a65cf0f583134acbcbf5a1ba
http://hdl.handle.net/10044/1/66283

Identifying Ashkenazi Jewish BRCA1/2 founder variants in individuals who do not self-report Jewish ancestry.

Autor: Tennen RI; 23andMe, Inc., 223 N Mathilda Ave, Sunnyvale, CA, 94086, USA., Laskey SB; 23andMe, Inc., 223 N Mathilda Ave, Sunnyvale, CA, 94086, USA., Koelsch BL; 23andMe, Inc., 223 N Mathilda Ave, Sunnyvale, CA, 94086, USA., McIntyre MH; 23andMe, Inc., 223 N Mathilda Ave, Sunnyvale, CA, 94086, USA., Tung JY; 23andMe, Inc., 223 N Mathilda Ave, Sunnyvale, CA, 94086, USA. joyce@23andme.com.

Publikováno v: Scientific reports [Sci Rep] 2020 May 06; Vol. 10 (1), pp. 7669. Date of Electronic Publication: 2020 May 06.

Circum-Mediterranean influence in the Y-chromosome lineages associated with prostate cancer in Mexican men: A Converso heritage founder effect?

Autor: Álvarez-Topete, Esmeralda¹ (AUTHOR), Torres-Sánchez, Luisa E.² (AUTHOR), Hernández-Tobías, Esther A.³ (AUTHOR), Véliz, David⁴ (AUTHOR), Hernández-Pérez, Jesús G.^2,5 (AUTHOR), de Lourdes López-González, Ma.¹ (AUTHOR), Meraz-Ríos, Marco Antonio⁶ (AUTHOR), Gómez, Rocío¹ (AUTHOR) mrgomez@cinvestav.mx

Publikováno v: PLoS ONE. 8/16/2024, Vol. 19 Issue 8, p1-33. 33p.

Phenotypic analysis of 23andMe survey data: Treatment-resistant depression from participants' perspective.

Autor: Li QS; Neuroscience Therapeutic Area, Janssen Research & Development, LLC, 1800 American Blvd, Titusville, NJ, USA. Electronic address: QLi2@its.jnj.com., Tian C; 23andMe, Inc., Mountain View, CA, USA., McIntyre MH; 23andMe, Inc., Mountain View, CA, USA., Sun Y; Neuroscience Therapeutic Area, Janssen Research & Development, LLC, 1800 American Blvd, Titusville, NJ, USA., Hinds DA; 23andMe, Inc., Mountain View, CA, USA., Narayan VA; Neuroscience Therapeutic Area, Janssen Research & Development, LLC, 1800 American Blvd, Titusville, NJ, USA.

Publikováno v: Psychiatry research [Psychiatry Res] 2019 Aug; Vol. 278, pp. 173-179. Date of Electronic Publication: 2019 Jun 11.