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of 390
pro vyhledávání: '"McIntyre Lauren M"'
Genomic complexity is a growing field of evolution, with case studies for comparative evolutionary analyses in model and emerging non-model systems. Understanding complexity and the functional components of the genome is an untapped wealth of knowled
Externí odkaz:
http://arxiv.org/abs/2211.02546
Publikováno v:
BMC Bioinformatics, Vol 12, Iss 1, p 427 (2011)
Abstract Background Many analyses of gene expression data involve hypothesis tests of an interaction term between two fixed effects, typically tested using a residual variance. In expression studies, the issue of variance heteroscedasticity has recei
Externí odkaz:
https://doaj.org/article/4090d0ad51d647aca5ae07a9da416e1c
Autor:
Oberg Ann L, Amin Victor, Morse Alison M, Lopiano Kenneth K, McIntyre Lauren M, Young Linda J, Nuzhdin Sergey V
Publikováno v:
BMC Genomics, Vol 12, Iss 1, p 293 (2011)
Abstract Background RNA-seq is revolutionizing the way we study transcriptomes. mRNA can be surveyed without prior knowledge of gene transcripts. Alternative splicing of transcript isoforms and the identification of previously unknown exons are being
Externí odkaz:
https://doaj.org/article/3b989ce5a56e4905a250e066db3ad7a1
Autor:
Telonis-Scott Marina, Walts Brandon, Wright Anita C, Crécy-Lagard Valérie de, Gulig Paul A, McIntyre Lauren M
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 512 (2010)
Abstract Background Vibrio vulnificus is the leading cause of reported death from consumption of seafood in the United States. Despite several decades of research on molecular pathogenesis, much remains to be learned about the mechanisms of virulence
Externí odkaz:
https://doaj.org/article/ad3f8f88a8e24d6d8f8234f5b3cee1a6
Autor:
Calabrese Peter P, Graze Rita M, McIntyre Lauren M, Bickel Ryan D, Main Bradley J, Nuzhdin Sergey V
Publikováno v:
BMC Genomics, Vol 10, Iss 1, p 422 (2009)
Abstract Background Allele-specific expression (ASE) assays can be used to identify cis, trans, and cis-by-trans regulatory variation. Understanding the source of expression variation has important implications for disease susceptibility, phenotypic
Externí odkaz:
https://doaj.org/article/d0401d93bd9c41918fe6d49d46298451
Autor:
Harshman Lawrence G, Wayne Marta L, Pickering Andrew, Brisson Jennifer A, Nuzhdin Sergey V, McIntyre Lauren M
Publikováno v:
BMC Genomics, Vol 10, Iss 1, p 124 (2009)
Abstract Background A molecular process based genotype-to-phenotype map will ultimately enable us to predict how genetic variation among individuals results in phenotypic alterations. Building such a map is, however, far from straightforward. It requ
Externí odkaz:
https://doaj.org/article/961b23bafe13454da60458512364df06
Publikováno v:
BMC Genomics, Vol 7, Iss 1, p 320 (2006)
Abstract Background Beta-adrenergic receptor agonists (BA) induce skeletal muscle hypertrophy, yet specific mechanisms that lead to this effect are not well understood. The objective of this research was to identify novel genes and physiological path
Externí odkaz:
https://doaj.org/article/215c536892744fadae99421d2ad3881a
Publikováno v:
BMC Genetics, Vol 4, Iss 1, p 10 (2003)
Abstract Background It has been reported in the quantitative trait locus (QTL) literature that when testing for QTL location and effect, the statistical power supporting methodologies based on two markers and their estimated genetic map is higher tha
Externí odkaz:
https://doaj.org/article/ba586ffd769346bba92a7abdf66b2f41
Publikováno v:
BMC Evolutionary Biology, Vol 2, Iss 1, p 2 (2002)
Abstract Background Factors that affect flowering vary among different plant species, and in the grasses in particular the exact mechanism behind this transition is not fully understood. The brown midrib (bm) mutants of maize (Zea mays L.), which hav
Externí odkaz:
https://doaj.org/article/29e781658f7f4efc97bcaf539c1e3d72
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