General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

Autor: GALA Trial Collaborative Group, C Lewis, S, P Warlow, C, R Bodenham, A, Colam, B, M Rothwell, P, Torgerson, D, Dellagrammaticas, D, Horrocks, M, Liapis, C, P Banning, A, Gough, M, J Gough, M, Fraser, A, Grant, S, Hunter, J, Leigh-Brown, A, Paterson, M, Soosay, V, Young, A, Williamson, A, Dean, Z, Mazzoli, T, Ricci, S, Valenti, D, Bamford, J, Beard, J, Dearden, M, Murray, G, Ruckley, V, E Norman, P, Sedivy, P, Idla, A, Schmitz-Rixen, T, Maritati, G, Bodenham, A, Cokic, N, Doppler, W, Hlatky, P, Koelblinger, C, Raith, C, Zölss, C, Dimmitt, S, Gharbi, R, Hankey, G, Maden, A, P Mwipatayi, B, Sieunarine, K, Tan, A, Turner, G, Wesseldine, A, T M, E Davis, Audzei, P, Davidovski, I, Dedul, D, Hetsiuk, A, Kornievich, S, Gao, J, Y-G, Huang, Jing, G, H, Li, Y-J, Li, Liu, B, C-W, Liu, J-D, Wu, W, Ye, C-H, Yu, Ban, T, Buljan, K, Candrlic, K, Dapic, D, Ilijasevic, M, Istvanic, T, Kovac, B, Kvolik, S, Lehner, V, Pinotic, K, Hudorović, N, Ivanec, Z, Lovricević, I, Mazul-Sunko, B, Novotny, Z, D De Syo, Vuković, V, Biebl, O, Dolecek, L, C El Samman, Kalasova, H, Kubricht, V, Matous, P, Michalek, P, Stajnrt, M, Stern, M, Svec, M, Vitasek, P, Vrzal, J, Weiss, K, Janousek, L, Kieslichova, E, Mazarova, V, Piza, P, Vychodil, P, Dulovcova, V, Fiksa, J, Hruby, J, Maresch, M, Mathias, M, Rubes, D, Tosenovsky, P, Vidim, T, Henzl, M, Riman, J, Ziegler, Z, Drabek, P, Hrbac, T, Reguli, S, Stigler, J, Bachleda, P, Drac, P, Hudecek, M, Koutna, J, Sanak, D, Utikal, P, Goldemund, D, Gregor, Z, Pavlikova, J, Podlaha, J, Privara, M, Staffa, R, Vlachovsky, R, Barankova, L, Chlouba, V, Fiedler, J, Prazak, P, Priban, V, Wierer, A, Ellervee, T, Järve, H, Sell, A, Taba, P, Kolbassov, V, Kullamaa, S, Paavel, T, Abramishvili, N, Bokuchava, M, Kachapuridze, N, Kipiani, K, Papashvili, K, Pargalava, N, Adili, F, Dietz, A, Neidhart, G, Nentwig, G, M Sitzer, O, Beno, M, Essink-Hassels, M, Lander, K, Ruemenapf, G, Breuer, P, Heldt, R, Melichar, G, Rieper, J, H Eckstein, H, Poppert, H, Schneider, G, Andrikopoulos, V, Angel, A, Bakogiannis, K, Dermitzaki, M, Georgakis, P, Lioupis, C, Maras, D, G Moulakakis, K, Sfyroeras, G, Arato, E, Gyevnar, Z, Hardi, P, Kasza, G, Kollar, L, Menyhei, G, Pal, E, Sinay, L, Verzar, Z, Volgyi, E, S Elmakias, S, Harah, E, Kristal, K, Lebi, D, Leonty, Y, Levy, D, Milo, R, Yoffe, B, Bissi, M, Cappellini, B, Cassamali, T, Corino, L, Denkewitz, T, Ghilardi, G, Massetto, N, P Di Mauro, Tommasino, C, Bartolucci, R, Buffa, V, M Corsi, F, D'Avino, E, F Di Cesare, L Di Pirro, Lappa, A, Luzzi, S, Menichetti, A, Nesi, F, Pannone, A, Picozzi, P, Pogany, G, Rabitti, G, Severi, L, Avella, R, Biandolino, P, P Giomarelli, P, R Monfregola, M, Palasciano, G, Peccianti, V, Pieragalli, D, Setacci, C, Setacci, F, Sirignano, P, Bordoni, M, Casadei, V, Cugnasca, M, A De Troia, Geremia, L, Guffanti, P, G Lo Guercio, V Maniaci, M, Mauri, Morbidelli, A, Aletta, A, Costanzo, E, D'Arrigo, G, F Di Stefano, Lomeo, A, Maugeri, S, C Monea, M, Scardavilli, G, Scolaro, A, Aloisi, P, Ciccozzi, A, Manno, M, Marrelli, A, Martinazzo, C, Mastromarino, A, Petrassi, C, Piroli, A, Spartera, C, Ventura, M, Alessandrini, F, Carissimi, C, M Centritto, E, Cinelli, G, C De Filippo, Liberatoscioli, G, Modugno, P, Rossi, M, T Attanzio, M, Bajardi, G, Bellisi, M, Machi, P, Salemi, S, Savettieri, G, A Crea, M, V di Lazzaro, Ferrante, A, Guarneri, S, Manni, R, Snider, F, Stefanuto, C, Berardi, G, Bianchi, A, Comis, M, Cumbo, P, Fadde, M, Ferrero, E, Ferri, M, Filardo, A, Gaggiano, A, Ganzaroli, M, Labate, C, Maggio, D, Mennuti, G, Minicucci, S, Musso, A, Nessi, F, Pasquino, M, Perretta, L, Piazza, S, Verdecchia, C, Viazzo, A, Antico, A, Battan, E, Ciarlo, M, Giardini, G, G Luca Iob, Marinello, C, Piccolo, D, Bove, R, Castrucci, T, Lorido, A, Sammarco, S, Bruzzone, B, Cannata, D, Colotto, P, Finocchi, C, Giudici, N, Mambrini, S, Mazzei, R, Palombo, D, Pellegrino, A, Rousas, N, Viacava, A, Ermirio, D, Faga, D, Simoni, G, Benedetti-Valentini, F, Gabrielli, R, Garofano, R, Gossetti, B, Guerricchio, R, Irace, L, Lenzi, G, Gedins, M, Kisis, K, Krievins, D, Krustina, I, Lietuvietis, E, Malina, M, Morlata, N, Rits, J, Thor, S, Ivanova, P, Kikule, I, Liepa, V, Ligers, A, Stengrevica, N, Vnukova, N, Zvirgzdins, V, P J A, M Brouwers, H Geelkerken, R, Stam, A, M A, M Simon, T den Hoed, P, Oltmans, M, Rettig, H, F Veen, H, Zuidgeest, D, Feldo, M, Kesik, J, Kobusiewicz, W, Łatkiewicz, D, Myślinski, W, Przywara, S, Terlecki, P, Wroński, J, Zubilewicz, T, Alfonso, G, Azevedo, E, R de Albuquerque, Mansilha, A, Al-Salman, M, K Aldaif, A, A Alnasr, T, A El Dawlatly, A, Elkayali, A, M Rabee, H, Chudikova, E, Chudá, I, Dulka, T, Goldenberg, Z, Lofaj, P, Pavlikova, M, Pisar, M, Sefranek, V, Slysko, R, Tomka, J, Tóthová, Z, Zita, Z, A Cairols, M, Iborra, E, Mercadal, M, Rubio, F, Canovas, D, Cobo, L, Gimenez-Gaibar, A, Gonzalez, E, Gonzalo, B, Guilera, N, Hospedales, J, J Laso, M, Perez, J, Solanich, T, Hensater, M, Karlström, L, Kjällman, L, Rosengren, L, C-A, Ewaldsson, Gillgren, P, T-B, Käll, Konrad, P, Lindkvist, M, Nilsson, L, Takolander, R, E von Zweigbergk, Cinar, B, Coruh, T, Kurc, E, Ozsoy, D, Sargin, M, Tutkavul, K, Yekeler, I, Aksoy, M, Aksoy, S, Kurtoglu, M, Arar, C, Canbaz, S, Celik, Y, Ege, T, Ketenc, S, Sunar, H, Unal, S, Asik, I, Bengisun, U, Koksoy, C, Yucemen, N, C Berridge, D, Caldicott, L, Cooper, J, Cross, M, Ford, H, Fuller, R, Gamlin, F, Homer-Vanniasinkum, S, Howell, S, Kent, P, Lumb, A, A I, D Mavor, D J, A Scott, Shah, M, Wanklyn, P, S Budd, J, Mcateer, P, Shaw, L, Dewar, R, H Lewis, M, Potter, C, Richards, H, Roberts, R, Townsend, E, Wagle, A, Woodford, P, Hall, G, Holdsworth, R, Macleod, M, Michels, L, P A, G Sandercock, Sudlow, C, Woods, A, S Abraham, J, Bukhari, M, Bush, A, Calvey, J, Chadwick, I, Krishnaprasad, K, Oldham, T, Tomlinson, M, Vickers, A, Wilson, D, Wilson, P, Greystone, S, C Grocott, E, Hayes, W, Haynes, S, Jenkins, C, Jenkins, D, Moore, W, Nyamekye, I, Overstall, P, Riseboro, S, Williams, H, Boyle, J, Duane, D, Gaunt, M, J Kirkpatrick, P, Martin, P, E Risdall, J, Scurrah, N, L Turner, C, Varty, K, T Ferguson, I, Horsfall, S, C Mitchell, D, Robinson, S, Frankel, J, E Morris, G, Phillips, M, Sansome, A, J Sparkes, D, Williams, J, Ashton, W, Baker, S, Clark, M, G Darke, S, Dunnill, R, Hargreaves, M, Jenkinson, D, Thomson, C, White, N, D Wijesinghe, L, Bapat, P, A Barrett, J, D Blair, S, Chandrasekar, R, Lawrence, G, Lowe, D, Sangster, G, Smith, M, M Van Miert, K Das, S, Malik, O, Nel, M, Rakowicz, W, Aukett, M, Carmichael, M, Colchester, A, R Taylor, P, Wood, C, Ageed, A, J Boom, S, Ghosh, S, Godfrey, J, Hewitt-Gray, J, Mcdiarmid, I, Yousif, S, Ziarkowski, A, Al-Din, A, Carpenter, M, Ch'Ng, K, J Curley, P, Davey, R, Henderson, B, F Hossain, J, D Irvine, C, Loizou, L, Main, A, Stanners, A, Muldoon, T, V Soong, C, Wiggam, I, P Armon, M, Burrows, M, Holmes, L, K Metcalf, A, Nunn, D, Abdul-Hamid, A, Akomalafe, B, Bryce, J, Chetter, I, Samaan, A, Briley, D, Collin, J, Darby, C, Dobson, M, Foex, P, Grange, C, Handa, A, Hands, L, E Higham, H, J M, T Perkins, Sear, J, Stoneham, M, Hamilton, G, Judge, C, Morris-Vincent, P, Pegg, M, A Wilson, L, I Aldoori, M, B E, A Dafalla, Kumar, N, I F, C Hay, Jefferson, P, Muir, I, Peel, W, Rutherford, J, Sathianathan, J, Wight, S, Williams, D, Wrathall, W, Bachoo, P, Brittenden, J, Counsell, C, Patey, R, Read, J, L de Cossart, K Dimitri, S, Edwards, P, Fergusson, N, Jameson, P, Somauroo, J, Taylor, V, D Aravindan, P, Brocklehurst, I, Mirza, S, N Namushi, R, O Oshodi, T, Ruff, D, A Solomon, S, Vassallo, J, Egbe, M, Halstead, G, Onwudike, M, Putland, A, Roberts, N, A Salaman, R, Watson, D, Caine, S, Day, J, Lamont, P, J Murphy, P, Smith, F, Beacham, K, J Dorman, P, Lambert, D, Rodgers, H, Collas, D, Sarin, S, Shah, J, S Baht, H, Banks, J, Cowie, L, Gunathilagan, G, Hargroves, D, Insall, R, G Smithard, D, K Chadha, D, R Pillay, W, Rashid, J, Sayles, J, Hill, S, Lawton, G, M Lloyd, C, Marsh, A, Clarke, G, J Lonsdale, R, Venables, G, Cross, R, Lord, B, Mcilmoyle, J, Y Osman, H, Robinson, J, Chant, H, Mate, A, Sim, D, Upton, P, Thomas, D, H Wolfe, J, Mccollum, C, O'Neill, P, Bernatsky, V, Bondar, L, Karpenko, A, Mamonova, M, Muz, N, Yavorsky, V

BACKGROUND: The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df0fb21fa8d2361b2f5c82a7ee23dfb
http://hdl.handle.net/11573/229926

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Autor: Bath, Philip M, Woodhouse, Lisa J, Appleton, Jason P, Beridze, Maia, Christensen, Hanne, Dineen, Robert A, Duley, Lelia, England, Timothy J, Flaherty, Katie, Havard, Diane, Heptinstall, Stan, James, Marilyn, Krishnan, Kailash, Markus, Hugh S, Montgomery, Alan A, Pocock, Stuart J, Randall, Marc, Ranta, Annemarei, Robinson, Thompson G, Scutt, Polly, Venables, Graham S, Sprigg, Nikola, Christensen, L M, Bentsen, L, Krarup Hansen, C, Thomsen, T T, Kruuse, C, Jensen, H H, Hansen, S S, Petrovic, V, Beridze, N, Kakabadze, N, Kherkheulidze, T, Kakabadze, D, Toidze, I, Lobjanidze, N, Akiashvili, N, Tevdoradze, A, Khizanishvili, N, Tsanava, T, Taylor, R, Iniesta, I, Kok, J, Duignan, J, Funnell, M, Cariga, P, Rodriguez, M, Watson, I J, Tennant, S, Macleod, M, Furnace, J, Gow, H, Irvine, J, Joyson, A, Nelson, S, Taylor, V, Smith, M, Bellfield, R, Hairsine, B, Davies, R, Dodd, A, Corrigan, J, Doherty, M, Ahmed, A, Denniss, C, Johnson-Holland, S, Kay, K A, Palau, R Icart, Auld, G, Daboo, P, Erande, R, Grimwood, G, Hove, D, Howaniec, L, Redjep, O, Rangasamay, R, Butt, G, Sandler, D, Reddan, J, Stafford, S, McIlmoyle, J, Maguire, S, Murphy, P, Chambers, J, Guthrie, L, Osborn, M, Steele, A, Burn, M, Benford, A, Misra, A, Hilton, D, O'Brien, E, Amis, E, Finlay, S, Mitchell, J, Geraghty, O, Harvey, K, Hazel, B, Mashate, S, Wilding, P, Sajid, M, Ball, M, Gascoyne, R, Sivakumar, R, Wright, A, Chatterjee, K, Booth, S, Eccleson, H, Kelly, C, Leason, S, Perkins, C, Bruce, D, Brown, E, Clayton, S, Garside, M, Rogers, G, Lawrence, E, Mahmood, S, Watchurst, C, Chadha, D, Glover, L, Holford, L, Smith, K, Walstow, D, Williams, R, O'Shea, L, Goodsell, J, Athulathmudali, C, Barbon, E, Namushi, R, Jacob, P, Johnson, L, Morse, D, McGhee, C, Speirs, O, Atkinson, S, Peacocke, A, Langhorne, P, Graham, R, Wright, F, McAlpine, C, Ravindrane, A, Bajoriene, M, Matter, L, Windebank, S, Giallombardo, E, Dellafera, D, Eglinton, C, Wilson, J, Broughton, D, Chapman, K, Dixon, L, Zaidi, M, Ayes, K, Kessell, J, Manawadu, D, Adegbaju, O, Aeron-Thomas, J, Anderson, K, Brigden, A, Cattermole, E, Good, J, Hassan, S, Khoromana, E, Lee-Carbon, L, Marks, K, Mckenzie, E, Sikondari, N, Cooper, M, Whysall, K, Wynter, I, Bamford, J, Hassan, A, Wanklyn, P, Kambafwile, M, Makawa, L, Waugh, D, Veraque, E, Soliman, MGG, Arif, S, Brown, R, Butler, S, Hewitt, C, Hindle, J, Pusalkar, A, Beadle, H, Chan, K, Siddiqui, M, Dangri, P, Buddha, S, Asokanathan, A, Mistri, A, Eveson, D, Musarrat, K, Manning, L, Anand, S, Christian, P, Khan, S, Patel, C, Sein, M, Banns, J, Gibson, E, Gordon, T, Gruenbeck, Y, Wong, S, Datta, P, Bateman, G, Jackson, L, Needle, A, Duodu, Y, Oliver, R, Padilla-Harris, C, Barber, M, Esson, D, Brodie, F, McInnes, C, Fotherby, K, Butler, D, Morgan, D, Preece, K, Willberry, A, Dent, M, Hammonds, F, Hunt, J, Vernon, C, O'Kane, D, Faola, F, Lai, P, O'Callaghan, J, Smith, C, Price, C, Lakey, R, Riddell, V, Smith, A, Storey, G, Munshi, S, Buck, A, Clarke, J, Gilzeane, N, Godfrey, M, Keshvara, R, Richardson, C, Roffe, J, Ryan, L, Shelton, F, Sunman, W, Tittle, A, Tomlinson, J, Whittamore, K, Wilkes, G, Owusu-Agyei, P, Temple, N, Mangion, D, Hardwick, A, Netherton, K, Nor, A Mohd, Hyams, B, Norman, S, Persad, N, Ragab, S, Dickson, C, Dube, J, Jinks, E, Knops, K, Wadams, B, Ali, K, Gaylard, J, Spurling, G, Sztriha, L, Ajao, T, Alao, M, Chan, F K, Webster, P, Howard, P, Dobson, T J, Hyatt, L, Sims, D, Cunningham, J, Esisi, B, Cassidy, T, Bokhari, M, McClelland, B, Mokoena, B, Gunathilagan, G, Jones, S, Reader, M, Thomas, G, Tilby, S, Findlay, P, Barrett, F, Leslie, F, Ross, S, Shread, I, Okwera, J, Howe, J, Harrington, F, Courtauld, G, Schofield, C, Donnelly, R, Maddula, M, Scott, J, Beavan, J, Muhidden, K, Memon, I, Clarke, M, Hedstrom, A, Mills, L, Hemsley, A, Bowring, A, Boxall, L, Kingwell, H, Keenan, S, Roughan, C, Manoj, A, Cox, P, Fletcher, G, Lopez, P, Emsley, H, Gregary, B, McLoughlin, A, Raj, S, Roffe, C, Abano, N, Barry, A, Butler, A, Carpio, R, Castro, K, Finney, K, Gomm, S, Hiden, J, Grocott, J, Lyjko, S, Maguire, H, Remegoso, A, Sanyal, R, Stevens, S, Natarajan, I, Chembala, J, Muddegowda, G, Warusevitane, A, Blight, A, Balazikova, O, Lawlor, C, Shaw, L, Button, D, Howcroft, D, Lucas, S, Madigan, B, McCann, S, Dixit, A, Barkat, A, Davis, J, Fawcett, M, Finlay, L, Guy, H, Hays, C, Hogg, V, Horsley, E, Hubbuck, C, Pringle, C, Stevenson, C, Storey, K, Thompson, T, Woodward, S, Banerjee, A, Allcock, C, Merotra, S, Douglass, C, Campbell, E, Jarapa, R, Johnes, M, Keaveney, C, Marsden, T, Naing, Z, Perez, J, Shaw, K, Black, T, Anthony, A, Clarke, C, Paterson, J, Deighton, K, Temlett, E, Blank, C, Doyle, C, Duty, S, Gill, K, Harkness, K, Kamara, C, Richards, E, Elfandi, K, Guyler, P, Harman, P, Khuoge, C, Kunhunny, S, Tysoe, S, Moynihan, B, Adedoyin, T, Chopra, N, Dayal, N, Ghatala, R, Jeyaraj, N, Jones, I, Kennedy, F, Kerin, L, Khanom, N, Lewis, S, Maheswaran, S, Montague, L, Niemierko, M, O'Reilly, J, Trippier, S, Watson, F, Wilkinson, P, Young, E, Dizayee, K, Cochrane, H, O'Connell, J, Mokoena, L, Osborne, E, Nair, A, Greig, J, Jenkins, C, Powell, J, Price, F, Chowdhury, M, Brixey, S, Hunt, L, Rands, N, Rose, G, Stoddart, S, Srinivasan, M, Motherwell, N, Shekhar, R, Fuller, T, Lankester, A, Lingwood, P, Rankin, C, Webb, H, Jupp, B, Bell, J, Hann, G, Longland, B, Ovington, C, Bhaskaran, B, Ayres, G, Bailey, C, Bearne, H, Buxton, J, Fitzell, P, Hilaire, C, Kelly, D, Szabo, S, Tomlin, D, Gamble, E, Charles, B, Kumar, R, Fluskey, T, Mellor, Z, Peters, J, Sutton, V, Kenton, A, Martin, I, Nyabadza, S, Ghosh, S, Henry, M, Kumar, B, Bruce, D, Ambulo, C, Crawford, S, Nozedar, T, Platton, M, Cvoro, V, Couser, M, McCormick, K, Wilkinson, D, Javaid, K, Hurdowar, S, Attygalle, T, Sundayi, S, Orugun, O, Crowther, H, Jolly, R, Poultney, U, Azim, A, Krasinska-Chavez, M, White, J, Sengupta, N, Margalef, J, Metiu, M G, Meenakshisundaram, S, Dealing, S, Hargroves, D, Beranova, E, Cowie, L, Rudenko, H, Thomson, A, Verrion, A, Rashed, K, Board, S, Buckley, C, Hayward, D, Jenkins, K, Keeling, E, Rowland-Axe, R, Vickers, C, Wood, D, Lehman, A, Erande, R, Patel, M, Russell, H, Rehman, H, Forrest, D, Farren, P

Publikováno v: The Lancet; March 2018, Vol. 391 Issue: 10123 p850-859, 10p

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.