Zobrazeno 1 - 10
of 35
pro vyhledávání: '"McGuire, Cian"'
Autor:
McGuire, Cian
Aim: We have recently developed electrophysiological recordings of human visceral afferent (HVA) activity in isolated gastrointestinal tissues. The aim of the this study was 1) test the mechano- and chemosensitivity of HVAs, 2) characterise subpopula
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667331
Autor:
Hockley, James R.F., Boundouki, George, Cibert-Goton, Vincent, McGuire, Cian, Yip, Ping K., Chan, Christopher, Tranter, Michael, Wood, John N., Nassar, Mohammed A., Blackshaw, L. Ashley, Aziz, Qasim, Michael, Gregory J., Baker, Mark D., Winchester, Wendy J., Knowles, Charles H., Bulmer, David C.
Publikováno v:
In Pain October 2014 155(10):1962-1975
Autor:
Cibert-Goton, Vincent, Kung, Victor WS, McGuire, Cian, Hockley, James RF, Tranter, Michael M, Dogra, Harween, Belai, Abi, Blackshaw, L Ashley, Sanger, Gareth J, Knowles, Charles H, Araujo, Eduardo JA, Winchester, Wendy J, Bulmer, David C
The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d996c5e411781241fe054ee68533f9
Autor:
McGuire, Cian, Boundouki, George, Hockley, James RF, Reed, David, Cibert-Goton, Vincent, Peiris, Madusha, Kung, Victor, Broad, John, Aziz, Qasim, Chan, Christopher, Ahmed, Shafi, Thaha, Mohamed A, Sanger, Gareth J, Blackshaw, L Ashley, Knowles, Charles H, Bulmer, David C
OBJECTIVE: The development of effective visceral analgesics free of deleterious gut-specific side effects is a priority. We aimed to develop a reproducible methodology to study visceral nociception in human tissue that could aid future target identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9df3f9c900d7fc497c39ad15992bec
Autor:
Hockley, James RF, González-Cano, Rafael, McMurray, Sheridan, Tejada-Giraldez, Miguel A, McGuire, Cian, Torres, Antonio, Wilbrey, Anna L, Cibert-Goton, Vincent, Nieto, Francisco R, Pitcher, Thomas, Knowles, Charles H, Baeyens, José Manuel, Wood, John N, Winchester, Wendy J, Bulmer, David C, Cendán, Cruz Miguel, McMurray, Gordon
KEY POINTS: Voltage-gated sodium channels play a fundamental role in determining neuronal excitability. Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute and inflammatory somatic pain in mice and humans but its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5073f0d6ef727da37b8b8f7fa9884539
Wiley Online Library
Wiley Online Library
Autor:
Hockley, James R. F., Tranter, Michael M., McGuire, Cian, Boundouki, George, Cibert-Goton, Vincent, Thaha, Mohamed A., Blackshaw, L. Ashley, Michael, Gregory J., Baker, Mark D., Knowles, Charles H., Winchester, Wendy J., Bulmer, David C.
Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders. Purine and pyrimidine nucleotides (e.g., ATP and UTP) are strongly implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd10a2993d452bf69520a43103301ef
https://www.repository.cam.ac.uk/handle/1810/284205
https://www.repository.cam.ac.uk/handle/1810/284205
Autor:
Mendez, Daniel C, Stover, Alexander E, Rangel, Anthony D, Brick, David J, Nethercott, Hubert E, Torres, Marissa A, Khalid, Omar, Wong, Andrew Ms, Cooper, Jonathan D, Jester, James V, Monuki, Edwin S, McGuire, Cian, Le, Steven Q, Kan, Shih-Hsin, Dickson, Patricia I, Schwartz, Philip H
Mucopolysaccharidosis type I (MPS I) is an inherited α-L-iduronidase (IDUA, I) deficiency in which glycosaminoglycan (GAG) accumulation causes progressive multisystem organ dysfunction, neurological impairment, and death. Current MPS I mouse models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::06ac81f818fe4b86ce530451406dd333
https://escholarship.org/uc/item/72b3586j
https://escholarship.org/uc/item/72b3586j
Akademický článek
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Akademický článek
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Autor:
Hockley, James R. F., González‐Cano, Rafael, McMurray, Sheridan, Tejada‐Giraldez, Miguel A., McGuire, Cian, Torres, Antonio, Wilbrey, Anna L., Cibert‐Goton, Vincent, Nieto, Francisco R., Pitcher, Thomas, Knowles, Charles H., Baeyens, José Manuel, Wood, John N., Winchester, Wendy J., Bulmer, David C., Cendán, Cruz Miguel, McMurray, Gordon
Publikováno v:
Journal of Physiology; Apr2017, Vol. 595 Issue 8, p2661-2679, 19p