Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder

Autor: McGrouther, Caroline C., Rangan, Aaditya V., Di Florio, Arianna, Elman, Jeremy A., Schork, Nicholas J., Kelsoe, John

Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. In this paper, we leverage recent advances in heterogeneity analy

Externí odkaz: http://arxiv.org/abs/2405.00159

A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data.

Autor: Rangan, Aaditya V.^1,2 rangan@cims.nyu.edu, McGrouther, Caroline C.¹, Kelsoe, John³, Schork, Nicholas⁴, Stahl, Eli⁵, Zhu, Qian⁶, Krishnan, Arjun⁷, Yao, Vicky⁶, Troyanskaya, Olga^2,6, Bilaloglu, Seda⁸, Raghavan, Preeti⁸, Bergen, Sarah⁹, Jureus, Anders^9,10, Landen, Mikael⁹, null, null

Publikováno v: PLoS Computational Biology. 5/14/2018, Vol. 14 Issue 5, p1-29. 29p. 4 Diagrams, 8 Graphs.

Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.

Autor: McGrouther CC; Courant Institute of Mathematical Sciences, New York University, New York, NY, United States of America., Rangan AV; Courant Institute of Mathematical Sciences, New York University, New York, NY, United States of America., Di Florio A; School of Medicine, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom., Elman JA; Department of Psychiatry, University of California San Diego, San Diego, CA, United States of America., Schork NJ; The Translational Genomics Research Institute, Quantitative Medicine and Systems Biology, Phoenix, AZ, United States of America., Kelsoe J; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States of America.

Publikováno v: ArXiv [ArXiv] 2024 Oct 27. Date of Electronic Publication: 2024 Oct 27.