Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.

Autor: Hung SH; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA.; The Viral Information Institute, San Diego State University, San Diego, CA, USA., Elliott GI; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA., Ramkumar TR; Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA., Burtnyak L; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., McGrenaghan CJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Alkuzweny S; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA., Quaiyum S; Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA., Iwata-Reuyl D; Department of Chemistry, PO Box 751 Portland State University, Portland, OR 97207, USA., Pan X; School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, UK., Green BD; School of Biological Sciences, Institute for Global Food Security, Queen's University Belfast, Belfast, UK., Kelly VP; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., de Crécy-Lagard V; Department of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.; University of Florida Genetics Institute, Gainesville, FL 32610, USA., Swairjo MA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA.; The Viral Information Institute, San Diego State University, San Diego, CA, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Jan 25; Vol. 51 (2), pp. 935-951.

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.

Autor: Hayes P; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland., Fergus C; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland., Ghanim M; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland., Cirzi C; Division of Epigenetics, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Burtnyak L; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland., McGrenaghan CJ; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland., Tuorto F; Division of Epigenetics, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.; Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.; Division of Biochemistry, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty, Heidelberg University, 68167 Mannheim, Germany., Nolan DP; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland., Kelly VP; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 2 Dublin, Ireland.

Publikováno v: Nutrients [Nutrients] 2020 Mar 24; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 24.