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Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

Autor: McGlade Cj, Stanley K. Liu

Publikováno v: Oncogene. 17:3073-3082

Shc proteins are important substrates of receptor and cytoplasmic tyrosine kinases that couple activated receptors to downstream signaling enzymes. Phosphorylation of Shc tyrosine residues 239 and 317 leads to recruitment of the Grb2-Sos complex, thu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43499abb6d028370831553eca5cd9ad
https://doi.org/10.1038/sj.onc.1202337

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Autor: Barber, Diane, Gillis, LC, Berry, DM, Minden, MD, McGlade, CJ, Barber, DL

Publikováno v: Barber, Diane; Gillis, LC; Berry, DM; Minden, MD; McGlade, CJ; & Barber, DL. (2013). Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3xd5f59r

Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and B-cell acute lymphoblastic leukemia (B-ALL), are driven by the oncogenic BCR-ABL fusion protein. Animal modeling experiments utilizing retroviral transduction and subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c47b0f838587f26e2ac93e7be9fc9f37
http://www.escholarship.org/uc/item/3xd5f59r

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Individual adenovirus E1B proteins induce transformation independently but by additive pathways

Autor: McGlade Cj, Philip E. Branton, Takayesu D, McLorie W

Publikováno v: Journal of General Virology. 72:1467-1471

The specific contributions of human adenovirus type 5 early region 1B (E1B) proteins were examined using mutants which synthesize these products individually. In cooperation with E1A, transformation of primary baby rat kidney cells was achieved with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8189628a9258081b474681f6d773e3cf
https://doi.org/10.1099/0022-1317-72-6-1467

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Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity

Autor: Julie D. Forman-Kay, McGlade Cj, Sébastien J. F. Vincent, Tony Pawson, Lewis E. Kay, Shun-Cheng Li, Catherine Zwahlen

Publikováno v: Nature structural biology. 5(12)

The phosphotyrosine-binding (PTB) domain of Numb, a protein involved in asymmetric cell division, has recently been shown to bind to the adapter protein Lnx through an LDNPAY sequence, to the Numb-associated kinase (Nak) through a sequence that does

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9f0ca2064283c573dd881c7c9bbbfe
https://pubmed.ncbi.nlm.nih.gov/9886281

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