Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations

Autor: Hossain, Amer A., McGinn, Jon, Meeske, Alexander J., Modell, Joshua W., Marraffini, Luciano A.

Publikováno v: In Cell Host & Microbe 13 October 2021 29(10):1482-1495

A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway

Autor: Czech, Benjamin, Preall, Jonathan B., McGinn, Jon, Hannon, Gregory J.

Publikováno v: In Molecular Cell 6 June 2013 50(5):749-761

Cas9 cleavage of viral genomes generates immunological memories during the type II CRISPR-Cas response

Autor: Nussenzweig, Philip M., McGinn, Jon, Marraffini, Luciano A.

Publikováno v: Cell Host Microbe

Type II CRISPR-Cas systems defend prokaryotes from bacteriophage infection through the acquisition of short viral DNA sequences known as spacers, that are transcribed into short RNA guides to specify the targets of the Cas9 nuclease. To counter the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65a640b2c2c2fff1c1703cf9652fb497
https://europepmc.org/articles/PMC7558852/

CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration

Autor: McGinn, Jon, Marraffini, Luciano A.

Publikováno v: In Molecular Cell 3 November 2016 64(3):616-623

An expanded genetic toolkit for inducible expression and targeted gene silencing in Rickettsia parkeri .

Autor: McGinn J; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Wen A; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Edwards DL; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Brinkley DM; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Lamason RL; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 15. Date of Electronic Publication: 2024 Mar 15.