Výsledky vyhledávání - "McGeer Patrick L"

Akademický článek

The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ

Autor: Hashioka Sadayuki, Klegeris Andis, McGeer Patrick L

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 113 (2012)

Abstract Backgrounds Increasing evidence shows that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) possesses potent anti-inflammatory and immunomodulatory properties. It is tempting to evaluate the potential of SAHA as a the

Externí odkaz: https://doaj.org/article/077ff106adbe4799a0deae7ca8db54ec

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Akademický článek

Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis

Autor: Yu Sheng, McCall Sherman, Zurn Anne D, Kasas Sandor, Miklossy Judith, McGeer Patrick L

Publikováno v: Journal of Neuroinflammation, Vol 5, Iss 1, p 40 (2008)

Abstract Background The long latent stage seen in syphilis, followed by chronic central nervous system infection and inflammation, can be explained by the persistence of atypical cystic and granular forms of Treponema pallidum. We investigated whethe

Externí odkaz: https://doaj.org/article/adc982e8b69141a3a86f09e2d87b2308

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Akademický článek

Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease

Autor: Paton Athena, Martins Georgia, Taddei Kevin, Balakrishnan Kelvin, Hedley Ross, Laws Simon M, D'Costa Katarzyna J, Gnjec Anastazija, Verdile Giuseppe, Gandy Samuel E, Broe G Anthony, Brooks William S, Bennett Hayley, Piguet Olivier, Price Patricia, Miklossy Judith, Hallmayer Joachim, McGeer Patrick L, Martins Ralph N

Publikováno v: Journal of Neuroinflammation, Vol 5, Iss 1, p 36 (2008)

Abstract Background Inflammatory changes are a prominent feature of brains affected by Alzheimer's disease (AD). Activated glial cells release inflammatory cytokines which modulate the neurodegenerative process. These cytokines are encoded by genes r

Externí odkaz: https://doaj.org/article/7151322006ff42e99a4a29f8e1b8dfa2

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Akademický článek

Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs

Autor: McGeer Patrick L, Klegeris Andis, Hosokawa Masato

Publikováno v: Journal of Neuroinflammation, Vol 1, Iss 1, p 17 (2004)

Abstract Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sc

Externí odkaz: https://doaj.org/article/be1e88dba7684c29bdf62a802c90c6ff

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