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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.

Autor: Wityak J; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States., McGee KF; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Conlon MP; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Song RH; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Duffy BC; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Clayton B; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Lynch M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Wang G; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Freeman E; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Haber J; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Kitchen DB; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Manning DD; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Ismail J; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Khmelnitsky Y; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Michels P; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Webster J; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Irigoyen M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Luche M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Hultman M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Bai M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Kuok ID; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Newell R; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States., Lamers M; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Leonard P; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Yates D; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Matthews K; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Ongeri L; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Clifton S; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Mead T; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom., Deupree S; ∥Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States., Wheelan P; ∥Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States., Lyons K; ⊥Pharmacokinetics Consultant to CHDI, P.O. Box 64, Holland, New York 14080, United States., Wilson C; #Evotec, 114 Milton Park, Abingdon, OX14 4SA, United Kingdom., Kiselyov A; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States., Toledo-Sherman L; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States., Beconi M; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States., Muñoz-Sanjuan I; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States., Bard J; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States., Dominguez C; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Apr 09; Vol. 58 (7), pp. 2967-87. Date of Electronic Publication: 2015 Mar 19.

Studies in bicyclo[3.1.0]hexane methanolysis. Ring opening of activated cyclopropanes under acidic and basic conditions.

Autor: Lim YH; Department of Chemistry, 1901 N. 13th Street, Temple University, Philadelphia, Pennsylvania 19122, USA., McGee KF Jr, Sieburth SM

Publikováno v: The Journal of organic chemistry [J Org Chem] 2002 Sep 06; Vol. 67 (18), pp. 6535-8.

Solvent-dependent stereoselectivity of bis-2-pyridone [4 + 4] photocycloaddition is due to H-bonded dimers.

Autor: Sieburth SM; Department of Chemistry, State University of New York, Stony Brook 11794-3400, USA. ssieburth@sunysb.edu, McGee KF Jr

Publikováno v: Organic letters [Org Lett] 1999 Dec 02; Vol. 1 (11), pp. 1775-7.