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Mical1 deletion in tyrosinase expressing cells affects mouse running gaits.

Autor: Micovic K; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada., Canuel A; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Remtulla A; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Chuyen A; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada., Byrsan M; Biomedical Engineering Program, Toronto Metropolitan University, Toronto, Ontario, Canada., McGarry DJ; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada., Olson MF; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.; Biomedical Engineering Program, Toronto Metropolitan University, Toronto, Ontario, Canada.

Publikováno v: Genes, brain, and behavior [Genes Brain Behav] 2024 Oct; Vol. 23 (5), pp. e70004.

THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.

Autor: Blomme A; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Peter C; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Mui E; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Rodriguez Blanco G; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., An N; Laboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium., Mason LM; School of Engineering, University of Glasgow, Glasgow, UK., Jamieson LE; Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow, UK., McGregor GH; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Lilla S; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Ntala C; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Patel R; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Thiry M; GIGA-Neurosciences, Unit of Cell and Tissue Biology, University of Liège, Liège, Belgium., Kung SHY; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver, BC, Canada., Leclercq M; Laboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium., Ford CA; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Rushworth LK; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., McGarry DJ; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Mason S; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Repiscak P; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Nixon C; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Salji MJ; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Markert E; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., MacKay GM; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Kamphorst JJ; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Graham D; Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow, UK., Faulds K; Centre for Molecular Nanometrology, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow, UK., Fazli L; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver, BC, Canada., Gleave ME; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver, BC, Canada., Avezov E; UK Dementia Research Institute at University of Cambridge, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Edwards J; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Yin H; School of Engineering, University of Glasgow, Glasgow, UK., Sumpton D; CRUK Beatson Institute, Garscube Estate, Glasgow, UK., Blyth K; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Close P; Laboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium., Murphy DJ; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Zanivan S; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK., Leung HY; CRUK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2022 Mar 07; Vol. 14 (3), pp. e14764. Date of Electronic Publication: 2022 Jan 11.

MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.

Autor: McGarry DJ; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada., Armstrong G; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada., Castino G; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada., Mason S; Cancer Research UK Beatson Institute, Glasgow, UK., Clark W; Cancer Research UK Beatson Institute, Glasgow, UK., Shaw R; Cancer Research UK Beatson Institute, Glasgow, UK., McGarry L; Cancer Research UK Beatson Institute, Glasgow, UK., Blyth K; Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Olson MF; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. Electronic address: Michael.olson@ryerson.ca.

Publikováno v: Cancer letters [Cancer Lett] 2021 Oct 28; Vol. 519, pp. 226-236. Date of Electronic Publication: 2021 Jul 24.

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization.

Autor: Rudzka DA; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Spennati G; School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK., McGarry DJ; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Chim YH; School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK., Neilson M; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Ptak A; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Munro J; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Kalna G; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Hedley A; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Moralli D; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Green C; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Mason S; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Blyth K; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Mullin M; Electron Microscopy Facility, Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK., Yin H; School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK., Olson MF; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK michael.olson@ryerson.ca.; Institute of Cancer Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

Publikováno v: Journal of cell science [J Cell Sci] 2019 May 31; Vol. 132 (11). Date of Electronic Publication: 2019 May 31.