Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling

Autor: Soomro, M, Stadler, M, Dand, N, Bluett, J, Jadon, D, Jalali‐najafabadi, F, Duckworth, M, Ho, P, Marzo‐Ortega, H, Helliwell, PS, Ryan, AW, Kane, D, Korendowych, E, Simpson, MA, Packham, J, McManus, R, Gabay, C, Lamacchia, C, Nissen, MJ, Brown, MA, Verstappen, SMM, Van Staa, T, Barker, JN, Smith, CH, Chalmers, R, Flohr, C, Watson, K, Prieto‐Merino, D, Alabas, O, Barker, J, Becher, G, Bewley, A, Burden, D, Morrison, S, Laws, P, Evans, I, Griffiths, C, Ahmed, S, Kirby, B, Kleyn, E, Lawson, L, Mackenzie, T, McPherson, T, McElhone, K, Murphy, R, Ormerod, A, Owen, C, Reynolds, N, Rashid, A, Smith, C, Warren, R, Siebert, S, Brown, S, McAteer, H, Schofield, J, FitzGerald, O, McHugh, N, Warren, RB, Bowes, J, Barton, A

Objectives Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f08440eaf5186fd6994b5803172b23bb

Risk of major cardiovascular events in patients with psoriasis receiving biologic therapies: a prospective cohort study

Autor: Rungapiromnan, W., Mason, K.J., Lunt, M., McElhone, K., Burden, A. D., Rutter, M.K., Warren, R.B., Griffiths, C.E.M., Ashcroft, D.M., Barker, Jonathan, Benham, Marilyn, Browne, Fiona, Evans, Ian, Hussain, Sagair, Kirby, Brian, Lawson, Linda, McPherson, Tess, Murphy, Ruth, Owen, Caroline, Ormerod, Anthony, Pearson, Eleanor, Reynolds, Nick, Richards, Josh, Smith, Catherine, BADBIR Study Group, .

Background:\ud The cardiovascular safety profile of biologic therapies used for psoriasis is unclear.\ud \ud Objectives:\ud To compare the risk of major cardiovascular events (CVEs; acute coronary syndrome, unstable angina, myocardial infarction and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::247061b007c0ac992aff61dcccf8ae2f
https://eprints.gla.ac.uk/213580/1/213580.pdf

Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study

Autor: Pan, S., Tsakok, T., Dand, N., Lonsdale, D.O., Loeff, F.C., Bloem, K., de Vries, A., Baudry, D., Duckworth, M., Mahil, S., Pushpa-Rajah, A., Russell, A., Alsharqi, A., Becher, G., Murphy, R., Wahie, S., Wright, A., Griffiths, C.E.M., Reynolds, N.J., Barker, J., Warren, R.B., David Burden, A., Rispens, T., Standing, J.F., Smith, C.H., Benham, M., Evans, I., Hussain, S., Kirby, B., Lawson, L., Mason, K., McElhone, K., Ormerod, A., Owen, C., Barnes, M.R., Di Meglio, P., Emsley, R., Evans, A., Payne, K.

Publikováno v: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 13(2), 400-409. Wiley-Blackwell
Clinical and Translational Science, Vol 13, Iss 2, Pp 400-409 (2020)
Clinical and Translational Science
Pan, S, Tsakok, T, Dand, N, Lonsdale, D O, Loeff, F C, Bloem, K, de Vries, A, Baudry, D, Duckworth, M, Mahil, S, Pushpa-Rajah, A, Russell, A, Alsharqi, A, Becher, G, Murphy, R, Wahie, S, Wright, A, Griffiths, C E M, Reynolds, N J, Barker, J, Warren, R B, David Burden, A, Rispens, T & Standing, J F & Smith, C H 2020, ' Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis : A Prospective Pharmacokinetic-Pharmacodynamic Study ', Clinical and Translational Science, vol. 13, no. 2, pp. 400-409 . https://doi.org/10.1111/cts.12725, https://doi.org/10.1111/cts.12725
Pan, S, Tsakok, T, Dand, N, Lonsdale, D O, Loeff, F C, Bloem, K, de Vries, A, Baudry, D, Duckworth, M, Mahil, S, Pushpa-Rajah, A, Russell, A, Alsharqi, A, Becher, G, Murphy, R, Wahie, S, Wright, A, Griffiths, C E M, Reynolds, N J, Barker, J, Warren, R B, David Burden, A, Rispens, T, Standing, J F, Smith, C H, Benham, M, Evans, I, Hussain, S, Kirby, B, Lawson, L, Mason, K, McElhone, K, Ormerod, A, Owen, C, Barnes, M R, Di Meglio, P, Emsley, R, Evans, A & Payne, K 2020, ' Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study ', Clinical and Translational Science, vol. 13, no. 2, pp. 400-409 . https://doi.org/10.1111/cts.12725

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcea23ca63518fef3372a4c62f0df85
https://pure.amc.nl/en/publications/using-realworld-data-to-guide-ustekinumab-dosing-strategies-for-psoriasis(356fdda6-87b8-4fbc-8cc1-218c18c81fd8).html

Infliximab is associated with an increased risk of serious infection in patients with psoriasis in the U.K. and Republic of Ireland: results from the British Association of Dermatologists Biologic Interventions Register ( BADBIR )

Autor: Yiu, Z.Z.N., Ashcroft, D.M., Evans, I., McElhone, K., Lunt, M., Smith, C.H., Walton, S., Murphy, R., Reynolds, N.J., Ormerod, A.D., Griffiths, C.E.M., Warren, R.B.

Publikováno v: Yiu, Z Z N, Ashcroft, D M, Evans, I, McElhone, K, Lunt, M, Smith, C H, Walton, S, Murphy, R, Reynolds, N J, Ormerod, A D, Griffiths, C E M & Warren, R B 2019, ' Infliximab is associated with an increased risk of serious infection in patients with psoriasis in the U.K. and Republic of Ireland: results from the British Association of Dermatologists Biologic Interventions Register ( BADBIR ) ', British Journal of Dermatology . https://doi.org/10.1111/bjd.17036
The British Journal of Dermatology

Summary Background Patients with psoriasis and clinicians are concerned that infliximab may be associated with a risk of serious infections. Objectives To compare the risk of serious infections associated with infliximab in patients with chronic plaq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::44915d9e63a5b8b4248233c1908d425b
https://doi.org/10.1111/bjd.17036

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