Clinical remission attainment, definitions, and correlates among patients with severe asthma treated with biologics: a systematic review and meta-analysis.

Autor: Shackleford A; School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Heaney LG; School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK; Belfast Health & Social Care NHS Trust, Belfast, UK., Redmond C; School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., McDowell PJ; School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK; Belfast Health & Social Care NHS Trust, Belfast, UK., Busby J; School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK. Electronic address: john.busby@qub.ac.uk.

Publikováno v: The Lancet. Respiratory medicine [Lancet Respir Med] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.

Longitudinal assessment of glucocorticoid toxicity reduction in patients with severe asthma treated with biologic therapies.

Autor: McDowell PJ; Wellcome-Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry, and Biological Sciences; Queen's University Belfast, Northern Ireland; Department of Respiratory Medicine, Belfast City Hospital; Belfast Health and Social Care Trust, Northern Ireland. Electronic address: p.mcdowell@qub.ac.uk., Busby J; Centre for Public Health, School of Medicine, Dentistry, and Biological Sciences; Queen's University Belfast, Northern Ireland., Stone JH; Division of Rheumatology, Allergy, & Clinical Immunology; Massachusetts General Hospital; Harvard Medical School., Butler CA; Department of Respiratory Medicine, Belfast City Hospital; Belfast Health and Social Care Trust, Northern Ireland., Heaney LG; Wellcome-Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry, and Biological Sciences; Queen's University Belfast, Northern Ireland; Department of Respiratory Medicine, Belfast City Hospital; Belfast Health and Social Care Trust, Northern Ireland.

Publikováno v: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.

Clinical remission with biologic therapies in severe asthma: a matter of definition.

Autor: McDowell PJ; Wellcome Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.; Belfast Health and Social Care NHS Trust, Belfast, UK., McDowell R; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Busby J; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Eastwood MC; Wellcome Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.; Belfast Health and Social Care NHS Trust, Belfast, UK., Patel PH; Royal Brompton and Harefield Hospitals, London, UK., Jackson DJ; Guys Severe Asthma Centre, Guy's Hospital, School of Immunology and Microbial Sciences, King's College London, London, UK., Mansur A; University of Birmingham and Heartlands Hospital, Birmingham, UK., Patel M; Department of Respiratory Medicine, University Hospitals Plymouth NHS Trust, Derriford Hospital, Plymouth, UK., Burhan H; Royal Liverpool University Hospital, Liverpool, UK., Doe S; The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Chaudhuri R; NHS Greater Glasgow and Clyde Health Board, Gartnavel Hospital, Glasgow, UK., Gore R; Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Dodd JW; Academic Respiratory Unit, University of Bristol, Bristol, UK., Subramanian D; University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK., Brown T; Portsmouth Hospitals NHS Trust, Portsmouth, UK., Heaney LG; Wellcome Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK l.heaney@qub.ac.uk.; Belfast Health and Social Care NHS Trust, Belfast, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Jun 20; Vol. 63 (6). Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).

Ethnic variation in asthma phenotypic presentation and outcomes: a cross-sectional analysis of the UK Biobank.

Autor: Busby J; Centre for Public Health, Queen's University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK john.busby@qub.ac.uk., McDowell PJ; Centre for Experimental Medicine, Queen's University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK.; Belfast Health & Social Care NHS Trust, Belfast, UK., Pfeffer PE; Barts Health NHS Trust, London, UK., Mansur AH; University of Birmingham & Heartlands Hospital, University Hospitals Birmingham, Birmingham, UK., Heaney LG; Centre for Experimental Medicine, Queen's University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK.; Belfast Health & Social Care NHS Trust, Belfast, UK.

Publikováno v: Thorax [Thorax] 2024 Jan 18; Vol. 79 (2), pp. 186-190. Date of Electronic Publication: 2024 Jan 18.

Blood transcriptomic signature in type-2 biomarker-low severe asthma and asthma control.

Autor: Zeng X; Amgen Research, Amgen, Inc, South San Francisco, Calif., Qing J; Amgen Research, Amgen, Inc, South San Francisco, Calif., Li CM; Amgen Research, Amgen, Inc, South San Francisco, Calif., Lu J; Amgen Research, Amgen, Inc, South San Francisco, Calif., Yamawaki T; Amgen Research, Amgen, Inc, South San Francisco, Calif., Hsu YH; Amgen Research, Amgen, Inc, Cambridge, Mass., Vander Lugt B; Amgen Research, Amgen, Inc, South San Francisco, Calif., Hsu H; Amgen Research, Amgen, Inc, Thousand Oaks, Calif., Busby J; Wellcome-Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom., McDowell PJ; Wellcome-Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom., Jackson DJ; Guy's & St Thomas' NHS Trust and Department of Asthma, Allergy & Lung Biology, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom., Djukanovic R; School of Clinical and Experimental Sciences, University of Southampton, NIHR Southampton Biomedical Research Centre, Southampton, United Kingdom., Matthews JG; 23andMe, Sunnyvale, Calif., Arron JR; 23andMe, Sunnyvale, Calif., Bradding P; Department of Respiratory Sciences, Institute for Lung Health and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, United Kingdom., Brightling CE; Department of Respiratory Sciences, Institute for Lung Health and Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, United Kingdom., Chaudhuri R; Gartnavel General Hospital, Glasgow, and University of Glasgow, Glasgow, United Kingdom., Choy DF; Genentech, Inc, South San Francisco, Calif., Cowan D; NHS Greater Glasgow and Clyde, Stobhill Hospital, Glasgow, United Kingdom., Fowler SJ; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom., Hardman TC; Niche Science & Technology Ltd, Richmond, United Kingdom., Harrison T; Nottingham Respiratory NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Howarth P; School of Clinical and Experimental Sciences, University of Southampton, NIHR Southampton Biomedical Research Centre, Southampton, United Kingdom., Lordan J; The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Mansur AH; University of Birmingham and Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Menzies-Gow A; Royal Brompton & Harefield Hospitals, London, United Kingdom., Pavord ID; Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom., Walker S; Asthma UK & British Lung Foundation Partnership, London, United Kingdom., Woodcock A; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom; Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom., Heaney LG; Wellcome-Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom. Electronic address: l.heaney@qub.ac.uk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Oct; Vol. 152 (4), pp. 876-886. Date of Electronic Publication: 2023 Jun 12.