Postmortem Identification of Vascular Ehlers-Danlos Syndrome in a Lung Transplant Recipient

Autor: Mamta S. Chhabria, MD, Jee Young You, MD, Mrinalini Venkata Subramani, MD, Ruchi Yadav, MD, Charles R. Lane, MD, Carol Farver, MD, E. Rene Rodriguez, MD, Kenneth R. McCurry, MD, Marie M. Budev, DO, Carmela D. Tan, MD

Publikováno v: Transplantation Direct, Vol 9, Iss 6, p e1469 (2023)

Externí odkaz: https://doaj.org/article/22fffb979feb4ee0a61ea57853bec10f

Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.

Autor: McCurry MD; Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., D'Agostino GD; Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Walsh JT; Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Bisanz JE; Department of Biochemistry & Molecular Biology, Pennsylvania State University, State College, PA 16802, USA., Zalosnik I; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Dong X; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Morris DJ; Emeritus Professor of Pathology and Laboratory Medicine, Brown University Alpert School of Medicine, Providence, RI 02903, USA., Korzenik JR; Division of Gastroenterology, Hepatology and Endoscopy, Brigham & Women's Hospital, Boston, MA 02115, USA., Edlow AG; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Balskus EP; Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Turnbaugh PJ; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub-San Francisco, San Francisco, CA 94158, USA., Huh JR; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Devlin AS; Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sloan_devlin@g.harvard.edu.

Publikováno v: Cell [Cell] 2024 Jun 06; Vol. 187 (12), pp. 2952-2968.e13. Date of Electronic Publication: 2024 May 24.

A bacterial bile acid metabolite modulates T reg activity through the nuclear hormone receptor NR4A1.

Autor: Li W; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Hang S; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Fang Y; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Bae S; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA., Zhang Y; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zhang M; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wang G; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., McCurry MD; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Bae M; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Paik D; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Franzosa EA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rastinejad F; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Huttenhower C; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yao L; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lina_yao@hms.harvard.edu., Devlin AS; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sloan_devlin@hms.harvard.edu., Huh JR; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jun_huh@hms.harvard.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2021 Sep 08; Vol. 29 (9), pp. 1366-1377.e9. Date of Electronic Publication: 2021 Aug 19.

Development of a covalent inhibitor of gut bacterial bile salt hydrolases.

Autor: Adhikari AA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Seegar TCM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Ficarro SB; Department of Cancer Biology, Department of Oncologic Pathology, Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., McCurry MD; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Ramachandran D; Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconness Medical Center, Boston, MA, USA., Yao L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Chaudhari SN; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Ndousse-Fetter S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Banks AS; Division of Endocrinology, Metabolism, and Diabetes, Beth Israel Deaconness Medical Center, Boston, MA, USA., Marto JA; Department of Cancer Biology, Department of Oncologic Pathology, Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Devlin AS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. sloan_devlin@hms.harvard.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2020 Mar; Vol. 16 (3), pp. 318-326. Date of Electronic Publication: 2020 Feb 10.

Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents.

Autor: Nicolaou KC; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Pulukuri KK; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Rigol S; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Buchman M; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Shah AA; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Cen N; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., McCurry MD; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Beabout K; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States., Shamoo Y; Department of Chemistry, BioScience Research Collaborative and ‡Department of BioSciences, Rice University , 6100 Main Street, Houston, Texas 77005, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2017 Nov 08; Vol. 139 (44), pp. 15868-15877. Date of Electronic Publication: 2017 Oct 24.