Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection.

Autor: Aggarwal S; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Walker FC; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Weagley JS; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., McCune BT; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America., Wu X; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Schriefer LA; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Makimaa H; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Lawrence D; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Sridhar P; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America., Baldridge MT; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2024 May 03; Vol. 20 (5), pp. e1011961. Date of Electronic Publication: 2024 May 03 (Print Publication: 2024).

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.

Autor: Lu Q; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA., Liu J; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA., Zhao S; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Gomez Castro MF; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Laurent-Rolle M; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA., Dong J; Ab Studio, Inc., Hayward, CA 94545, USA., Ran X; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Damani-Yokota P; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Tang H; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Karakousi T; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA., Son J; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Kaczmarek ME; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Zhang Z; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA., Yeung ST; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., McCune BT; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Chen RE; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Tang F; BIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing 100871, China., Ren X; BIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing 100871, China., Chen X; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA., Hsu JCC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA., Teplova M; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA., Huang B; Ab Studio, Inc., Hayward, CA 94545, USA., Deng H; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Long Z; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Mudianto T; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA., Jin S; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Lin P; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Du J; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA., Zang R; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Su TT; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA., Herrera A; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA., Zhou M; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Yan R; Joint Research Center of Hangzhou First Hospital Group and Westlake University, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Cui J; Kactus Biosystems Co., Ltd., Shanghai 201114, China., Zhu J; Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zhou Q; Joint Research Center of Hangzhou First Hospital Group and Westlake University, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China., Wang T; Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ma J; Department of Computer Science, Purdue University, West Lafayette, IN 47907, USA., Koralov SB; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA., Zhang Z; BIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing 100871, China., Aifantis I; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA., Segal LN; Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, New York, NY 10016, USA., Diamond MS; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Khanna KM; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Stapleford KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Cresswell P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA., Liu Y; Ab Studio, Inc., Hayward, CA 94545, USA., Ding S; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: siyuan.ding@wustl.edu., Xie Q; Westlake Laboratory of Life Sciences and Biomedicine, Center for Infectious Diseases Research, Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Basics Medical Sciences, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province 310024, China. Electronic address: xieqi@westlake.edu.cn., Wang J; Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA. Electronic address: jun.wang@nyulangone.org.

Publikováno v: Immunity [Immunity] 2021 Jun 08; Vol. 54 (6), pp. 1304-1319.e9. Date of Electronic Publication: 2021 May 09.

Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury.

Autor: Bailey AL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; adam.bailey@wustl.edu diamond@wusm.wustl.edu., Kang LI; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110., de Assis Barros D'Elia Zanella LGF; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, Sao Paulo, Brazil 01246 903.; State Civil Servant's Hospital, São Paulo, Brazil 04028-000., Silveira CGT; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, Sao Paulo, Brazil 01246 903., Ho YL; Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, Sao Paulo, Brazil 01246 903., Foquet L; Yecuris Corporation, Tualatin, OR 97062., Bial G; Yecuris Corporation, Tualatin, OR 97062., McCune BT; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110., Duarte-Neto AN; Department of Pathology, Clinical Hospital, School of Medicine, University of São Paulo, Sao Paulo, Brazil 01246 903., Thomas A; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006., Raué HP; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006., Byrnes K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110., Kallas EG; Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, Sao Paulo, Brazil 01246 903., Slifka MK; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006., Diamond MS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; adam.bailey@wustl.edu diamond@wusm.wustl.edu.; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 22; Vol. 117 (51), pp. 32648-32656. Date of Electronic Publication: 2020 Dec 02.

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.

Autor: Winkler ES; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Bailey AL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Nair S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., McCune BT; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Yu J; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Fox JM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Earnest JT; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Keeler SP; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Ritter JH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kang LI; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Dort S; SCIREQ Scientific Respiratory Equipment, Montreal, Quebec, Canada., Robichaud A; SCIREQ Scientific Respiratory Equipment, Montreal, Quebec, Canada., Head R; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Holtzman MJ; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. diamond@wusm.wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. diamond@wusm.wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. diamond@wusm.wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. diamond@wusm.wustl.edu.

Publikováno v: Nature immunology [Nat Immunol] 2020 Nov; Vol. 21 (11), pp. 1327-1335. Date of Electronic Publication: 2020 Aug 24.

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.

Autor: Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Rothlauf PW; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; Program in Virology, Harvard Medical School, Boston, MA, USA., Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Fox JM; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Smith BK; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Shrihari S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., McCune BT; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Harvey IB; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Keeler SP; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Bloyet LM; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA., Zhao H; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Ma M; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Adams LJ; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Winkler ES; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA., Holtzman MJ; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Fremont DH; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Whelan SPJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: spjwhelan@wustl.edu., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: diamond@wusm.wustl.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2020 Sep 09; Vol. 28 (3), pp. 465-474.e4. Date of Electronic Publication: 2020 Jul 30.