Effect of P-glycoprotein modulation with cyclosporin A on cerebrospinal fluid penetration of doxorubicin in non-human primates

Autor: Warren, K. E., Patel, M. C., Mccully, C. M., Montuenga, L. M., Frank Balis

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Scopus-Elsevier

PURPOSE: P-glycoprotein (Pgp) is a transmembrane drug efflux pump that is expressed in multidrug-resistant cancer cells and in a variety of normal tissues, including brain capillary endothelial cells which comprise the blood-brain barrier. We studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b840a5731c5be3459ab85a27feead37
https://hdl.handle.net/10171/20174

Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates.

Autor: Warren KE; Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-1928, USA. warrenk@exchange.nih.gov, McCully CM, Walsh TJ, Balis FM

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2000 Apr; Vol. 44 (4), pp. 1100-1.

2'-beta-fluoro-2',3'-dideoxyadenosine, lodenosine, in rhesus monkeys: plasma and cerebrospinal fluid pharmacokinetics and urinary disposition.

Autor: Roth JS; Laboratory of Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. rothj@dc37a.nci.nih.gov, McCully CM, Balis FM, Poplack DG, Kelley JA

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 1999 Oct; Vol. 27 (10), pp. 1128-32.