Bifunctional Nitrone-Conjugated Secondary Metabolite Targeting the Ribosome.

Autor: Limbrick EM; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Graf M; Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg 20146, Germany., Derewacz DK; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Nguyen F; Department of Biochemistry, University of Munich, 81377 Munich, Germany., Spraggins JM; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, United States.; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Wieland M; Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg 20146, Germany., Ynigez-Gutierrez AE; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Reisman BJ; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States., Zinshteyn B; Department of Molecular Biology and Genetics, Johns Hopkins University. Baltimore, Maryland 21205, United States., McCulloch KM; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Iverson TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Center for Structural Biology, Nashville, Tennessee 37232, United States., Green R; Department of Molecular Biology and Genetics, Johns Hopkins University. Baltimore, Maryland 21205, United States.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Wilson DN; Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg 20146, Germany., Bachmann BO; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, United States.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37205, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2020 Oct 28; Vol. 142 (43), pp. 18369-18377. Date of Electronic Publication: 2020 Oct 19.

The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.

Autor: Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM

Publikováno v: Biochemistry [Biochemistry] 2018 Dec 18; Vol. 57 (50), pp. 6827-6837. Date of Electronic Publication: 2018 Dec 07.

Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

Autor: Bensing BA; From the Division of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco and the Northern California Institute for Research and Education, San Francisco, California 94121., Loukachevitch LV; the Departments of Pharmacology and., McCulloch KM; the Departments of Pharmacology and., Yu H; the Department of Chemistry, University of California, Davis, California 95616, and., Vann KR; Biochemistry., Wawrzak Z; Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, Illinois 60439., Anderson S; Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, Illinois 60439., Chen X; the Department of Chemistry, University of California, Davis, California 95616, and., Sullam PM; From the Division of Infectious Diseases, Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco and the Northern California Institute for Research and Education, San Francisco, California 94121., Iverson TM; the Departments of Pharmacology and Biochemistry, Center for Structural Biology, and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, tina.iverson@vanderbilt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Apr 01; Vol. 291 (14), pp. 7230-40. Date of Electronic Publication: 2016 Feb 01.

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Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.

Autor: McCulloch KM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, McCranie EK; Department of Chemistry, Vanderbilt University, Nashville, TN 37235;, Smith JA; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232., Sarwar M; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, Mathieu JL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, Gitschlag BL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, Du Y; Department of Chemistry, Vanderbilt University, Nashville, TN 37235;, Bachmann BO; Department of Chemistry, Vanderbilt University, Nashville, TN 37235; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232 brian.bachmann@vanderbilt.edu tina.iverson@vanderbilt.edu., Iverson TM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232 brian.bachmann@vanderbilt.edu tina.iverson@vanderbilt.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Sep 15; Vol. 112 (37), pp. 11547-52. Date of Electronic Publication: 2015 Aug 03.