Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.

Autor: McCulloch KM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, McCranie EK; Department of Chemistry, Vanderbilt University, Nashville, TN 37235;, Smith JA; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232., Sarwar M; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, Mathieu JL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, Gitschlag BL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232;, Du Y; Department of Chemistry, Vanderbilt University, Nashville, TN 37235;, Bachmann BO; Department of Chemistry, Vanderbilt University, Nashville, TN 37235; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232 brian.bachmann@vanderbilt.edu tina.iverson@vanderbilt.edu., Iverson TM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232 brian.bachmann@vanderbilt.edu tina.iverson@vanderbilt.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Sep 15; Vol. 112 (37), pp. 11547-52. Date of Electronic Publication: 2015 Aug 03.