Výsledky vyhledávání - "McConnachie LA"

Akademický článek

Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules.

Autor: Yu J; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., Mu Q; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., Perazzolo S; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., Griffin JI; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., Zhu L; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., McConnachie LA; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., Shen DD; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA., Ho RJ; Departments of Pharmaceutics, University of Washington, Seattle, Washington, 98195, USA. rodneyho@uw.edu.; Departments of Bioengineering, University of Washington, Seattle, Washington, 98195, USA. rodneyho@uw.edu.

Publikováno v: Pharmaceutical research [Pharm Res] 2020 Sep 23; Vol. 37 (10), pp. 197. Date of Electronic Publication: 2020 Sep 23.

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Akademický článek

Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101.

Autor: Perazzolo S; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Shireman LM; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., McConnachie LA; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Koehn J; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Kinman L; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Lee W; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Lane S; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Collier AC; Department of Medicine, University of Washington, Seattle, Washington 98195; Center for AIDS Research, University of Washington, Seattle, Washington 98195., Shen DD; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195., Ho RJY; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195; Department of Bioengineering, University of Washington, Seattle, Washington 98195. Electronic address: rodneyho@uw.edu.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2020 May; Vol. 109 (5), pp. 1789-1801. Date of Electronic Publication: 2020 Jan 29.

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Akademický článek

Novel drug combination nanoparticles exhibit enhanced plasma exposure and dose-responsive effects on eliminating breast cancer lung metastasis.

Autor: Mu Q; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America., Yu J; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America., Griffin JI; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America., Wu Y; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America., Zhu L; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America., McConnachie LA; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America., Ho RJY; Department of Pharmaceutics, University of Washington, Seattle, WA, United States of America.; Department of Bioengineering, University of Washington, Seattle, WA, United States of America.

Publikováno v: PloS one [PLoS One] 2020 Mar 06; Vol. 15 (3), pp. e0228557. Date of Electronic Publication: 2020 Mar 06 (Print Publication: 2020).

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Akademický článek

Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.

Autor: Perazzolo S; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Shireman LM; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Koehn J; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., McConnachie LA; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Kraft JC; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Shen DD; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Ho RJY; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195; Department of Bioengineering, University of Washington, Seattle, Washington 98195. Electronic address: rodneyho@uw.edu.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2018 Dec; Vol. 107 (12), pp. 3153-3162. Date of Electronic Publication: 2018 Aug 16.

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Akademický článek

Extended cell and plasma drug levels after one dose of a three-in-one nanosuspension containing lopinavir, efavirenz, and tenofovir in nonhuman primates.

Autor: Koehn J; Department of Pharmaceutics., Iwamoto JF; Department of Pharmaceutics., Kraft JC; Department of Pharmaceutics., McConnachie LA; Department of Pharmaceutics., Collier AC; Department of Medicine.; Center for AIDS Research., Ho RJY; Department of Pharmaceutics.; Center for AIDS Research.; Department of Bioengineering, University of Washington, Seattle, Washington, USA.

Publikováno v: AIDS (London, England) [AIDS] 2018 Nov 13; Vol. 32 (17), pp. 2463-2467.

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Akademický článek

Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection.

Autor: McConnachie LA; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Kinman LM; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Koehn J; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Kraft JC; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Lane S; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Lee W; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195., Collier AC; Department of Medicine, University of Washington, Seattle, Washington 98195; Center for AIDS Research, University of Washington, Seattle, Washington 98195., Ho RJY; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195; Center for AIDS Research, University of Washington, Seattle, Washington 98195; Department of Bioengineering, University of Washington, Seattle, Washington 98195. Electronic address: rodneyho@uw.edu.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2018 Jul; Vol. 107 (7), pp. 1787-1790. Date of Electronic Publication: 2018 Mar 13.

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Akademický článek

Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook.

Autor: Mu Q; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA., Yu J; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA., McConnachie LA; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA., Kraft JC; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA., Gao Y; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA.; b Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy , Fuzhou University , Fuzhou , China., Gulati GK; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA., Ho RJY; a Department of Pharmaceutics , University of Washington , Seattle , WA , USA.; c Department of Bioengineering , University of Washington , Seattle , WA , USA.

Publikováno v: Journal of drug targeting [J Drug Target] 2018 Jun - Jul; Vol. 26 (5-6), pp. 435-447. Date of Electronic Publication: 2018 Jan 10.

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Akademický článek

Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation.

Autor: Kraft JC; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., McConnachie LA; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., Koehn J; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., Kinman L; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., Sun J; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., Collier AC; Department of Medicine, University of Washington, Seattle, WA 98195, United States; Center for AIDS Research, University of Washington, Seattle, WA 98195, United States., Collins C; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., Shen DD; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States., Ho RJY; Department of Pharmaceutics, University of Washington, Seattle, WA 98195, United States; Center for AIDS Research, University of Washington, Seattle, WA 98195, United States; Department of Bioengineering, University of Washington, Seattle, WA 98195, United States. Electronic address: rodneyho@uw.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2018 Apr 10; Vol. 275, pp. 229-241. Date of Electronic Publication: 2018 Feb 10.

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