Reactive astrocytes generated from human iPSC are pro-inflammatory and display altered metabolism.

Autor: McComish SF; Discipline of Physiology & School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., O'Sullivan J; Discipline of Physiology & School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Copas AMM; Discipline of Physiology & School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Imiolek M; Discipline of Physiology & School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Boyle NT; Discipline of Physiology & School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Crompton LA; Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol, UK; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK., Lane JD; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK., Caldwell MA; Discipline of Physiology & School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. Electronic address: maeve.caldwell@tcd.ie.

Publikováno v: Experimental neurology [Exp Neurol] 2024 Dec; Vol. 382, pp. 114979. Date of Electronic Publication: 2024 Sep 30.

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell- and nano-scale process extension for neural repair applications.

Autor: O'Connor C; Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin, Ireland.; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland., Mullally RE; Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin, Ireland.; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland., McComish SF; Department of Physiology, School of Medicine, TCD, Dublin, Ireland.; Trinity College Institute of Neuroscience, TCD, Dublin, Ireland., O'Sullivan J; Department of Physiology, School of Medicine, TCD, Dublin, Ireland.; Trinity College Institute of Neuroscience, TCD, Dublin, Ireland., Woods I; Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin, Ireland.; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland., Schoen I; School of Pharmacy and Biomolecular Sciences, RCSI, Dublin, Ireland., Garre M; Super-Resolution Imaging Consortium, Department of Chemistry RCSI, Dublin, Ireland., Caldwell MA; Department of Physiology, School of Medicine, TCD, Dublin, Ireland.; Trinity College Institute of Neuroscience, TCD, Dublin, Ireland., Dervan A; Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin, Ireland.; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland., O'Brien FJ; Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin, Ireland.; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland.

Publikováno v: Journal of anatomy [J Anat] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.

Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson's Disease Research and Therapeutic Development.

Autor: McComish SF; Department of Physiology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., MacMahon Copas AN; Department of Physiology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Caldwell MA; Department of Physiology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Publikováno v: Frontiers in neuroscience [Front Neurosci] 2022 May 16; Vol. 16, pp. 851058. Date of Electronic Publication: 2022 May 16 (Print Publication: 2022).

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

Autor: MacMahon Copas AN; Department of Physiology, School of Medicine, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., McComish SF; Department of Physiology, School of Medicine, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Fletcher JM; Department of Physiology, School of Medicine, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland.; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Caldwell MA; Department of Physiology, School of Medicine, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Publikováno v: Frontiers in neurology [Front Neurol] 2021 May 26; Vol. 12, pp. 666737. Date of Electronic Publication: 2021 May 26 (Print Publication: 2021).

Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes.

Autor: Hawkins SJ; Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol, UK.; Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK., Crompton LA; Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol, UK.; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK., Sood A; Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK., Saunders M; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK.; Department of Medical Physics & Bioengineering, St Michael's Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK., Boyle NT; Trinity College Institute of Neuroscience, Department of Physiology, Trinity College Dublin, Dublin, Ireland., Buckley A; Trinity College Institute of Neuroscience, Department of Physiology, Trinity College Dublin, Dublin, Ireland., Minogue AM; Trinity College Institute of Neuroscience, Department of Physiology, Trinity College Dublin, Dublin, Ireland., McComish SF; Trinity College Institute of Neuroscience, Department of Physiology, Trinity College Dublin, Dublin, Ireland., Jiménez-Moreno N; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK., Cordero-Llana O; Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol, UK., Stathakos P; Regenerative Medicine Laboratory, School of Clinical Sciences, University of Bristol, Bristol, UK.; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK., Gilmore CE; Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK., Kelly S; Neuroscience Institute @JFK Medical Center, Edison, NJ, USA., Lane JD; Cell Biology Laboratories, School of Biochemistry, University of Bristol, Bristol, UK., Case CP; Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK., Caldwell MA; Trinity College Institute of Neuroscience, Department of Physiology, Trinity College Dublin, Dublin, Ireland. maeve.caldwell@tcd.ie.

Publikováno v: Nature nanotechnology [Nat Nanotechnol] 2018 May; Vol. 13 (5), pp. 427-433. Date of Electronic Publication: 2018 Apr 02.