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Microglia protect against age-associated brain pathologies.

Autor: Munro DAD; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK. Electronic address: david.munro@ed.ac.uk., Bestard-Cuche N; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK., McQuaid C; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Chagnot A; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Shabestari SK; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA., Chadarevian JP; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA., Maheshwari U; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Szymkowiak S; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK., Morris K; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK., Mohammad M; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK., Corsinotti A; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK., Bradford B; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK., Mabbott N; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK., Lennen RJ; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK., Jansen MA; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA., Pridans C; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., McColl BW; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK., Keller A; Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Blurton-Jones M; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA., Montagne A; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK., Williams A; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK., Priller J; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Chancellor's Building, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Klinikum rechts der Isar, Technical University Munich, and German Center for Mental Health (DZPG), 81675 Munich, Germany; Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin and DZNE, 10117 Berlin, Germany. Electronic address: josef.priller@ed.ac.uk.

Publikováno v: Neuron [Neuron] 2024 Aug 21; Vol. 112 (16), pp. 2732-2748.e8. Date of Electronic Publication: 2024 Jun 18.

Author Correction: Microglia regulate central nervous system myelin growth and integrity.

Autor: McNamara NB; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK., Munro DAD; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Bestard-Cuche N; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Uyeda A; Departments of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Bogie JFJ; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.; University MS Centre, Hasselt University, Hasselt, Belgium., Hoffmann A; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK., Holloway RK; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.; Barlo Multiple Sclerosis Centre, St Michael's Hospital, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada.; Department of Immunology, The University of Toronto, Toronto, Ontario, Canada., Molina-Gonzalez I; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK., Askew KE; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Mitchell S; Wellcome Trust Centre for Cell Biology, King's Buildings, The University of Edinburgh, Edinburgh, UK., Mungall W; Biological and Veterinary Services, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Dodds M; Biological and Veterinary Services, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Dittmayer C; Department of Neuropathology and Neurocure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Moss J; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Rose J; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Szymkowiak S; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Amann L; Institute of Neuropathology, Centre for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., McColl BW; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Prinz M; Institute of Neuropathology, Centre for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Spires-Jones TL; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Stenzel W; Department of Neuropathology and Neurocure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Horsburgh K; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK., Hendriks JJA; Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.; University MS Centre, Hasselt University, Hasselt, Belgium., Pridans C; Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK., Muramatsu R; Departments of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Williams A; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Priller J; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin and DZNE, Berlin, Germany., Miron VE; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. Veronique.Miron@unityhealth.to.; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK. Veronique.Miron@unityhealth.to.; Medical Research Council Centre for Reproductive Health, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK. Veronique.Miron@unityhealth.to.; Barlo Multiple Sclerosis Centre, St Michael's Hospital, Toronto, Ontario, Canada. Veronique.Miron@unityhealth.to.; Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada. Veronique.Miron@unityhealth.to.; Department of Immunology, The University of Toronto, Toronto, Ontario, Canada. Veronique.Miron@unityhealth.to.

Publikováno v: Nature [Nature] 2024 Jul; Vol. 631 (8021), pp. E11.

Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment.

Autor: Askew KE; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Beverley J; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Sigfridsson E; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Szymkowiak S; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Emelianova K; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Dando O; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Hardingham GE; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Duncombe J; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Hennessy E; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Koudelka J; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Samarasekera N; Centre for Clinical Brain Sciences and Sudden Death Brain Bank, University of Edinburgh, Edinburgh, UK., Salman RA; Centre for Clinical Brain Sciences and Sudden Death Brain Bank, University of Edinburgh, Edinburgh, UK., Smith C; Centre for Clinical Brain Sciences and Sudden Death Brain Bank, University of Edinburgh, Edinburgh, UK., Tavares AAS; British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Gomez-Nicola D; School of Biological Sciences, University of Southampton, Southampton, UK., Kalaria RN; Clinical and Translational Research Institute, Newcastle University, Newcastle, UK., McColl BW; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Horsburgh K; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

Publikováno v: Glia [Glia] 2024 Feb; Vol. 72 (2), pp. 375-395. Date of Electronic Publication: 2023 Nov 01.

Association between circulating inflammatory biomarkers and functional outcome or perihaematomal oedema after ICH: a systematic review & meta-analysis.

Autor: Kirby C; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, Scotland, UK., Barrington J; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, Scotland, UK., Sondag L; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Universiteit, Nijmegen, Gelderland, The Netherlands., Loan JJM; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, Scotland, UK., Schreuder FHBM; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Universiteit, Nijmegen, Gelderland, The Netherlands., McColl BW; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, Scotland, UK., Klijn CJM; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Universiteit, Nijmegen, Gelderland, The Netherlands., Al-Shahi Salman R; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK., Samarasekera N; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2023 Nov 21; Vol. 8, pp. 239. Date of Electronic Publication: 2023 Nov 21 (Print Publication: 2023).