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EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity

Autor: Sun, Zhixiong, Xu, Xiguang, He, Jianlin, Murray, Alexander, Sun, Ming-an, Wei, Xiaoran, Wang, Xia, McCoig, Emmarose, Xie, Evan, Jiang, Xi, Li, Liwu, Zhu, Jinsong, Chen, Jianjun, Morozov, Alexei, Pickrell, Alicia M., Theus, Michelle H., Xie, Hehuang David

Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life experience is translated into storable epigenetic information remains largely unknown. With unbiased data-driven approaches, we predicted that Egr1, a transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2485::fe52c19f58edf07c6652b9efb7f74c73
https://hdl.handle.net/10919/94321

EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity.

Autor: Sun Z; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, 24061, USA., Xu X; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, 24061, USA., He J; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA., Murray A; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA., Sun MA; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA., Wei X; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA., Wang X; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA., McCoig E; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.; School of Neuroscience, Virginia Tech, Blacksburg, VA, 24061, USA., Xie E; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA., Jiang X; Department of Pharmacology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.; Institute of Hematology, Zhejiang University & Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, Zhejiang, 310058, China., Li L; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, 24061, USA., Zhu J; Department of Biochemistry, Virginia Tech, Blacksburg, VA, 24061, USA., Chen J; Department of Systems Biology, Beckman Research Institute of City of Hope, Monorovia, CA, 91016, USA., Morozov A; Department of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA, 24016, USA.; Virginia Tech Carilion Research Institute, Roanoke, VA, 24016, USA.; School of Biomedical Engineering and Sciences, Blacksburg, VA, 24061, USA., Pickrell AM; School of Neuroscience, Virginia Tech, Blacksburg, VA, 24061, USA., Theus MH; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA.; School of Neuroscience, Virginia Tech, Blacksburg, VA, 24061, USA., Xie H; Fralin Life Sciences Institute at Virginia Tech, Blacksburg, VA, 24061, USA. davidxie@vt.edu.; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, 24061, USA. davidxie@vt.edu.; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, 24061, USA. davidxie@vt.edu.; School of Neuroscience, Virginia Tech, Blacksburg, VA, 24061, USA. davidxie@vt.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Aug 29; Vol. 10 (1), pp. 3892. Date of Electronic Publication: 2019 Aug 29.