Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.

Autor: Fote GM; Department of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697.; Department of Neurological Surgery, UC Irvine School of Medicine, Orange, CA 92868., Eapen VV; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.; Casma Therapeutics, Cambridge, MA 02139., Lim RG; The University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Yu C; Department of Physiology and Biophysics, University of California, Irvine, CA 92697., Salazar L; Department of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868., McClure NR; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., McKnight J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Nguyen TB; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Heath MC; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Lau AL; Department of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868., Villamil MA; Department of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697., Miramontes R; Department of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868., Kratter IH; Center for Systems and Therapeutics, Gladstone Institutes, San Francisco, CA 94158.; Stanford Brain Stimulation Lab, Stanford, CA 94304.; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304., Finkbeiner S; Center for Systems and Therapeutics, Gladstone Institutes, San Francisco, CA 94158.; Department of Physiology, University of California, San Francisco, CA 94158.; Department of Neurology, University of California, San Francisco, CA 94158., Reidling JC; The University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115., Kaiser P; Department of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697., Huang L; Department of Physiology and Biophysics, University of California, Irvine, CA 92697., Housman DE; Koch Institute for Integrative Cancer Research, The Massachusetts Institute of Technology, Cambridge, MA 02139., Thompson LM; Department of Biological Chemistry, UC Irvine School of Medicine, Irvine, CA 92697.; The University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868.; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.; Center for Epigenetics and Metabolism, University of California, Irvine School of Medicine, University of California, Irvine, CA 92697., Steffan JS; The University of California Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Psychiatry and Human Behavior, UC Irvine School of Medicine, Orange, CA 92868.; Center for Epigenetics and Metabolism, University of California, Irvine School of Medicine, University of California, Irvine, CA 92697.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 06; Vol. 121 (32), pp. e2319091121. Date of Electronic Publication: 2024 Jul 29.