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pro vyhledávání: '"McClellan, William J."'
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Akademický článek
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Autor:
Xumiao Zhao, Kent D. Stewart, Moshe Weitzberg, Michael D. Wendt, Vincent L. Giranda, Todd W. Rockway, Robert A. Mantei, Geyer Andrew George, Vicki L. Nienaber, Vered Klinghofer, Mcclellan William J
Publikováno v:
Journal of Medicinal Chemistry. 47:303-324
The preparation and assessment of biological activity of 6-substituted 2-naphthamidine inhibitors of the serine protease urokinase plasminogen activator (uPA, or urokinase) is described. 2-Naphthamidine was chosen as a starting point based on synthet
Autor:
Cele Abad-Zapatero, Michael R. Michaelides, Terry Magoc, Patrick A. Marcotte, Daniel H. Albert, Jennifer J. Bouska, Donald J. Osterling, Kent D. Stewart, Mcclellan William J, Yujia Dai, Steven K. Davidsen, Keith B. Glaser
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound. Replacement of the pyrrolopyrimidine residue with a thienopyrimidine moiety led to a series of potent and selective Aurora inhibito
Publikováno v:
ChemInform. 23
An efficient diastereoselective synthesis of 2 is presented. A key feature is the intramolecular Diels-Alder reaction of o-quinodimethanes intermediates 3 derived from benzocyclobutenes 4 in which the exo-transition state is favored by incorporation
Autor:
Mcclellan William J, Robert E. Zelle
Publikováno v:
Tetrahedron Letters. 32:2461-2464
The methylenation of a variety of catechols is described, employing cesium carbonate and bromochloromethane in dimethylformamide t 110°C or acetonitrile at reflux. The corresponding methylenedioxy derivatives are obtained in 86-97 % yield. Utilizati
Publikováno v:
Tetrahedron Letters. 32:5469-5472
An efficient diastereoselective synthesis of 2 is presented. A key feature is the intramolecular Diels-Alder reaction of o-quinodimethanes intermediates 3 derived from benzocyclobutenes 4 in which the exo-transition state is favored by incorporation
Autor:
McClellan, William J., Dai, Yujia, Abad-Zapatero, Cele, Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Magoc, Terry J., Marcotte, Patrick A., Osterling, Donald J., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 September 2011 21(18):5620-5624
Autor:
Shi-Chu Ng ng, Xiaohong Song, Milan Bruncko, Cheol-Min Park, Steven W. Elmore, Stephen W. Fesik, Kunzer Aaron R, Wendt Michael D, Saul H. Rosenberg, Mcclellan William J, Barbara A. Belli, Wang Xilu, Thorsten Oost, Andrew M. Petros, Darlene Martineau, Alexander R. Shoemaker, Haichao Zhang, Mary K. Joseph, Michael J. Mitten, Paul Nimmer, Tilman Oltersdorf, Hong Ding
Publikováno v:
Journal of medicinal chemistry. 50(4)
Overexpression of the antiapototic proteins Bcl-2 and Bcl-xL provides a common mechanism through which cancer cells gain a survival advantage and become resistant to conventional chemotherapy. Inhibition of these prosurvival proteins is an attractive
Autor:
Paul Nimmer, David Frost, Wang Shen, Mcclellan William J, Jacqueline M. O'Connor, Robert B. Warner, Stephen K. Tahir, Joy Bauch, Alex R. Shoemaker, Shi-Chung Ng, Anatol Oleksijew, Steven W. Elmore, Tony Borre, Tilman Oltersdorf, Haichao Zhang, Mary K. Joseph, Milan Bruncko, Jason Stavropoulos, Kennan C. Marsh, Saul H. Rosenberg, Weiguo Qing, Hugh N. Nellans, Barbara A. Belli, Stephen W. Fesik, Ken Jarvis, Thomas Deckwirth, Baole Wang
Publikováno v:
Cancer research. 66(17)
Inhibition of the prosurvival members of the Bcl-2 family of proteins represents an attractive strategy for the treatment of cancer. We have previously reported the activity of ABT-737, a potent inhibitor of Bcl-2, Bcl-XL, and Bcl-w, which exhibits m