Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection

Autor: McCaughey, LC, Ritchie, ND, Douce, GR, Evans, TJ, Walker, D

Publikováno v: Scientific Reports

Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intraspecies competition. The potency and targeted action of bacteriocins suggests that they could be developed into clinically useful antibiotics against highly drug res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d2ea09a20127600a923edadf5423c650
https://hdl.handle.net/10453/58781

ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides.

Autor: Nolan LM; The ithree institute, University of Technology Sydney, Ultimo 2007, New South Wales, Australia.; National Heart and Lung Institute, Imperial College London, London SW3 6LR, UK., McCaughey LC; The ithree institute, University of Technology Sydney, Ultimo 2007, New South Wales, Australia.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Merjane J; The ithree institute, University of Technology Sydney, Ultimo 2007, New South Wales, Australia., Turnbull L; The ithree institute, University of Technology Sydney, Ultimo 2007, New South Wales, Australia., Whitchurch CB; The ithree institute, University of Technology Sydney, Ultimo 2007, New South Wales, Australia.; Microbes in the Food Chain Programme, Quadram Institute Bioscience, Norwich Research Park, NR4 7UQ and School of Biological Sciences, University of East Anglia, NR4 7TJ, Norwich, UK.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2020 Jul; Vol. 166 (7), pp. 669-678.

Structural and biophysical analysis of nuclease protein antibiotics.

Autor: Klein A; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Wojdyla JA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Swiss Light Source, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland., Joshi A; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Josts I; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, U.K., McCaughey LC; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, U.K., Housden NG; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Kaminska R; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Byron O; School of Life Sciences, University of Glasgow, University Place, Glasgow G12 8TA, U.K., Walker D; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, U.K., Kleanthous C; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

Publikováno v: The Biochemical journal [Biochem J] 2016 Sep 15; Vol. 473 (18), pp. 2799-812. Date of Electronic Publication: 2016 Jul 08.

Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection.

Autor: McCaughey LC; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.; The ithree institute, University of Technology Sydney, Ultimo, New South Wales, Australia.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK., Ritchie ND; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Douce GR; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Evans TJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Walker D; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

Publikováno v: Scientific reports [Sci Rep] 2016 Jul 22; Vol. 6, pp. 30201. Date of Electronic Publication: 2016 Jul 22.

Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor.

Autor: McCaughey LC; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Grinter R; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Josts I; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Roszak AW; WestCHEM, School of Chemistry, College of Science and Engineering, University of Glasgow, Glasgow, United Kingdom ; Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Waløen KI; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom ; School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Cogdell RJ; Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Milner J; Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Evans T; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Kelly S; Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Tucker NP; Strathclyde Institute for Pharmaceutical and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom., Byron O; School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Smith B; Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Walker D; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: PLoS pathogens [PLoS Pathog] 2014 Feb 06; Vol. 10 (2), pp. e1003898. Date of Electronic Publication: 2014 Feb 06 (Print Publication: 2014).