A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease.

Autor: Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C, Head, Elizabeth, Murphey, Heather L, Dowling, Amy L S, McCarty, Katie L, Bethel, Samuel R

Publikováno v: Journal of Alzheimer's Disease; 2012, Vol. 28 Issue 1, p1029-1042, 14p

Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease.

Autor: Sordo L; Department of Pathology and Laboratory Medicine, University of California, 837 Health Sciences Rd., Irvine, CA 92697, USA., Ubele MF; Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, 800 S. Limestone Street, Lexington, KY 19104, USA., Boaz KA; Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, 800 S. Limestone Street, Lexington, KY 19104, USA., Mefford JL; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., Jones ED; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., McCarty KL; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., van Rooyen HY; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., Smiley J; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., Bembenek Bailey SA; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., Perpich JA; Division of Laboratory Animal Resources, University of Kentucky, 204 Health Sciences Research Building, Lexington, KY 19104, USA., Meacham B; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, 740 Rose Street, Lexington, KY 19104, USA., Powell DK; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, 740 Rose Street, Lexington, KY 19104, USA., Bresch F; Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, 800 S. Limestone Street, Lexington, KY 19104, USA., Crump JW; Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, 800 S. Limestone Street, Lexington, KY 19104, USA., Phelan MJ; Department of Pathology and Laboratory Medicine, University of California, 837 Health Sciences Rd., Irvine, CA 92697, USA., Noche JA; Department of Neurobiology and Behavior, Department of Cognitive Sciences, University of California, 2205 McGaugh Hall, Irvine, CA 92697, USA., Stark CE; Department of Neurobiology and Behavior, Department of Cognitive Sciences, University of California, 2205 McGaugh Hall, Irvine, CA 92697, USA., Puskás LG; Aperus Pharma, Alsó kikötő sor 11/D, Szeged H-6726, Hungary., Norris CM; Sanders Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, 800 S. Limestone Street, Lexington, KY 19104, USA., Head E; Department of Pathology and Laboratory Medicine, University of California, 837 Health Sciences Rd., Irvine, CA 92697, USA. Electronic address: heade@uci.edu.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2025 Feb; Vol. 146, pp. 1-14. Date of Electronic Publication: 2024 Nov 10.

Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine.

Autor: Kimura S; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. s.kimura.res@gmail.com.; Department of Microbiology, Harvard Medical School, Boston, MA, USA. s.kimura.res@gmail.com.; Howard Hughes Medical Institute, Boston, MA, USA. s.kimura.res@gmail.com., Srisuknimit V; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., McCarty KL; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Dedon PC; Department of Biological Engineering, Massachusetts Institution of Technology, Cambridge, MA, USA.; Singapore-MIT Alliance for Research and Technology Antimicrobial Resistance Interdisciplinary Research Group, Singapore, Singapore., Kranzusch PJ; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Waldor MK; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. mwaldor@research.bwh.harvard.edu.; Department of Microbiology, Harvard Medical School, Boston, MA, USA. mwaldor@research.bwh.harvard.edu.; Howard Hughes Medical Institute, Boston, MA, USA. mwaldor@research.bwh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 11; Vol. 13 (1), pp. 5994. Date of Electronic Publication: 2022 Oct 11.

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict.

Autor: Eaglesham JB; Department of Microbiology, Harvard Medical School, Boston, United States.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, United States.; Harvard PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, United States., McCarty KL; Department of Microbiology, Harvard Medical School, Boston, United States.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, United States., Kranzusch PJ; Department of Microbiology, Harvard Medical School, Boston, United States.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, United States.; Harvard PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, United States.; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, United States.

Publikováno v: ELife [Elife] 2020 Nov 16; Vol. 9. Date of Electronic Publication: 2020 Nov 16.

Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease.

Autor: Helman AM; Department of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Siever M; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., McCarty KL; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Lott IT; Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Doran E; Department of Pediatrics, University of California, Irvine, Irvine, CA, USA., Abner EL; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Schmitt FA; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Department of Neurology, University of Kentucky, Lexington, KY, USA., Head E; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2019; Vol. 67 (1), pp. 103-112.