Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome.

Autor: Rittase WB; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., McCart EA; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Muir JM; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Bouten RM; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Slaven JE; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Mungunsukh O; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Bylicky MA; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Wilkins WL; Division of Comparative Pathology, The Armed Forces Radiobiology Research Institute/Uniformed Services University of Health Sciences, Bethesda, MD, United States of America., Lee SH; Division of Comparative Pathology, The Armed Forces Radiobiology Research Institute/Uniformed Services University of Health Sciences, Bethesda, MD, United States of America., Gudmundsson KO; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Di Pucchio T; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Olsen CH; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Du Y; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America., Day RM; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.

Publikováno v: PloS one [PLoS One] 2021 Aug 27; Vol. 16 (8), pp. e0256208. Date of Electronic Publication: 2021 Aug 27 (Print Publication: 2021).

Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice.

Autor: Mungunsukh O; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., George J; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., McCart EA; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Snow AL; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Mattapallil JJ; Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Mog SR; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA., Panganiban RAM; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Bolduc DL; Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA., Rittase WB; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Bouten RM; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Day RM; Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Publikováno v: Journal of radiation research [J Radiat Res] 2021 Mar 10; Vol. 62 (2), pp. 236-248.

Delayed Captopril Administration Mitigates Hematopoietic Injury in a Murine Model of Total Body Irradiation.

Autor: McCart EA; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Lee YH; Altimmune, Inc., Gaithersburg, MD, 20878, USA., Jha J; Rise Therapeutics, Rockville, MD, 20850, USA., Mungunsukh O; Department of Anesthesia, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Rittase WB; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Summers TA Jr; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Muir J; Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Day RM; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. regina.day@usuhs.edu.

Publikováno v: Scientific reports [Sci Rep] 2019 Feb 18; Vol. 9 (1), pp. 2198. Date of Electronic Publication: 2019 Feb 18.

Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury.

Autor: McCart EA; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Thangapazham RL; Department of Dermatology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Lombardini ED; Public Health Activity-Fort Carson, 1661 O'Connell Blvd, Fort Carson, CO 80913, USA., Mog SR; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5001 Campus Drive, College Park, MD 20740, USA., Panganiban RAM; Molecular and Integrative Physiological Sciences, Harvard TH Chan School of Public Health, 677 Huntington Ave., Boston, MA 02115, USA., Dickson KM; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Mansur RA; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Nagy V; Department of Radiation Dosimetry, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Kim SY; Department of Radiology, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA., Selwyn R; Department of Radiology, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA., Landauer MR; Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Darling TN; Department of Dermatology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA., Day RM; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.

Publikováno v: Journal of radiation research [J Radiat Res] 2017 Sep 01; Vol. 58 (5), pp. 636-646.

Effect of ionizing radiation on liver protein oxidation and metabolic function in C57BL/6J mice.

Autor: Barshishat-Kupper M; Department of Pharmacology, Uniformed Services University of the Health Sciences , Bethesda, MD , USA., Tipton AJ, McCart EA, McCue J, Mueller GP, Day RM

Publikováno v: International journal of radiation biology [Int J Radiat Biol] 2014 Dec; Vol. 90 (12), pp. 1169-78. Date of Electronic Publication: 2014 Aug 11.