Novel Synthesis of C-Methylated Phytocannabinoids Bearing Anti-inflammatory Properties.

Autor: Lavi Y; Medicinal Chemistry, Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel., Kogan NM; Medicinal Chemistry, Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.; Institute of Personalized and Translational Medicine, Molecular Biology, Ariel University, Ariel 4070000, Israel., Topping LM; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, U.K., Liu C; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, U.K., McCann FE; 180 Life Sciences, Menlo Park, California 94025, United States., Williams RO; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, U.K., Breuer A; Medicinal Chemistry, Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel., Yekhtin Z; Lautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel., Ezra AF; Medicinal Chemistry, Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel., Gallily R; Lautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel., Feldmann M; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, U.K.; 180 Life Sciences, Menlo Park, California 94025, United States., Mechoulam R; Medicinal Chemistry, Institute of Drug Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Apr 27; Vol. 66 (8), pp. 5536-5549. Date of Electronic Publication: 2023 Apr 14.

Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis

Autor: McCann, FE, Perocheau, DP, Ruspi, G, Blazek, K, Davies, ML, Feldmann, M, Dean, JL, Stoop, AA, Williams, RO

OBJECTIVE: Tumor necrosis factor (TNF) signals via 2 receptors, TNFR type I (TNFRI) and TNFRII, with distinct cellular distribution and signaling functions. In rheumatoid arthritis (RA), the net effect of TNFR signaling favors inflammatory responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::20a9f003f96bd16f817923e6504762f7
https://doi.org/10.1002/art.38755

Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse

Autor: Taner, SB, Onfelt, B, Pirinen, NJ, McCann, FE, Magee, AI, Davis, DM

Supramolecular clusters at the immunological synapse provide a mechanism for structuring complex communication networks between cells of the immune system. Regulating intra- and intercellular trafficking of proteins and lipids to and from the immunol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2ef217ff0518795ae28965f0407d1bbb
https://ora.ox.ac.uk/objects/uuid:3d69533d-8dd6-4302-b2b3-b19a00cea29b

Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300.

Autor: Williams LM; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom., McCann FE; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom., Cabrita MA; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom., Layton T; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom., Cribbs A; Botnar Research Centre, National Institute for Health Research Oxford Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7LD, United Kingdom., Knezevic B; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Fang H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Knight J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Zhang M; Biotherapeutics Department, Celgene Corporation, San Diego, CA 92121., Fischer R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Bonham S; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom., Steenbeek LM; Department of Plastic Surgery, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands., Yang N; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom., Sood M; Department of Plastic and Reconstructive Surgery, Broomfield Hospital, Mid and South Essex National Health Service Foundation Trust, Chelmsford CM1 4ET, Essex, United Kingdom., Bainbridge C; Pulvertaft Hand Surgery Centre, Royal Derby Hospital, University Hospitals of Derby and Burton National Health Service Foundation Trust, Derby DE22 3NE, United Kingdom., Warwick D; Department of Trauma and Orthopaedic Surgery, University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom., Harry L; Department of Plastic and Reconstructive Surgery, Queen Victoria Hospital National Health Service Foundation Trust, East Grinstead RH19 3DZ, United Kingdom., Davidson D; Department of Plastic and Reconstructive Surgery, St. John's Hospital, Livingston, West Lothian EH54 6PP, United Kingdom., Xie W; Biotherapeutics Department, Celgene Corporation, San Diego, CA 92121., Sundstrӧm M; Structural Genomics Consortium, Karolinska Centre for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden., Feldmann M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom; marc.feldmann@kennedy.ox.ac.uk jagdeep.nanchahal@kennedy.ox.ac.uk., Nanchahal J; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom; marc.feldmann@kennedy.ox.ac.uk jagdeep.nanchahal@kennedy.ox.ac.uk.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 25; Vol. 117 (34), pp. 20753-20763. Date of Electronic Publication: 2020 Aug 05.

Challenges and innovations in the surgical treatment of advanced Dupuytren disease by percutaneous needle fasciotomy: indications, limitations, and medico-legal implications.

Autor: Basile, Giuseppe¹, Amadei, Federico², Prevot, Luca Bianco¹, Tronconi, Livio Pietro³, Ciccarelli, Antonello⁴, Bolcato, Vittorio⁵, Zaami, Simona⁶ simona.zaami@uniroma1.it

Publikováno v: Journal of Orthopaedic Surgery & Research. 7/23/2024, Vol. 19 Issue 1, p1-10. 10p.