Latent Toxoplasma Infection and Higher Toxoplasma gondii Immunoglobulin G Levels Are Associated With Worse Neurocognitive Functioning in HIV-Infected Adults

Autor: Bharti, Ajay R., McCutchan, Allen, Deutsch, Reena, Smith, Davey M., Ellis, Ronald J., Cherner, Mariana, Woods, Steven P., Heaton, Robert K., Grant, Igor, Letendre, Scott L.

Publikováno v: Clinical Infectious Diseases, 2016 Dec . 63(12), 1655-1660.

Externí odkaz: https://www.jstor.org/stable/26373595

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Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

Autor: Mehta, Sanjay R, Perez-Santiago, Josue, Hulgan, Todd, Day, Tyler RC, Barnholtz-Sloan, Jill, Gittleman, Haley, Letendre, Scott, Ellis, Ronald, Heaton, Robert, Patton, Stephanie, Suben, Jesse D, Franklin, Donald, Rosario, Debralee, Clifford, David B, Collier, Ann C, Marra, Christina M, Gelman, Benjamin B, McArthur, Justin, McCutchan, Allen, Morgello, Susan, Simpson, David, Connor, James, Grant, Igor, Kallianpur, Asha

Publikováno v: Mehta, Sanjay R; Perez-Santiago, Josue; Hulgan, Todd; Day, Tyler RC; Barnholtz-Sloan, Jill; Gittleman, Haley; et al.(2017). Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment. JOURNAL OF NEUROINFLAMMATION, 14(1), 72. doi: 10.1186/s12974-017-0848-z. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0x24019k

Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, contains CpG motifs that act as TLR-9 lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::b4e9cdd8bf129fd310c6216ab1846e0d
http://www.escholarship.org/uc/item/0x24019k

Additional file 1: Table S1. of Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

Autor: Mehta, Sanjay, JosuĂŠ PĂŠrez-Santiago, Hulgan, Todd, Day, Tyler, Barnholtz-Sloan, Jill, Gittleman, Haley, Letendre, Scott, Ellis, Ronald, Heaton, Robert, Patton, Stephanie, Suben, Jesse, Franklin, Donald, Debralee Rosario, Clifford, David, Collier, Ann, Marra, Christina, Gelman, Benjamin, McArthur, Justin, McCutchan, Allen, Morgello, Susan, Simpson, David, Connor, James, Grant, Igor, Kallianpur, Asha

Categorization of the 216 individuals with follow-up neurocognitive assessments. Baseline assessments were compared to the assessment at the last follow-up visit, and individuals were categorized as improved, stable, or declined. Â Table S2. Univari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5438cf79b1f0fc738bbac44ae1df35ff