Zobrazeno 1 - 10
of 76
pro vyhledávání: '"McBriar, Mark"'
Autor:
Zhao, Zhiqiang, Pissarnitski, Dmitri A., Josien, Hubert B., Bara, Thomas A., Clader, John W., Li, Hongmei, McBriar, Mark D., Rajagopalan, Murali, Xu, Ruo, Terracina, Giuseppe, Hyde, Lynn, Song, Lixin, Zhang, Lili, Parker, Eric M., Osterman, Rebecca, Buevich, Alexei V.
Publikováno v:
In European Journal of Medicinal Chemistry 29 November 2016 124:36-48
Autor:
Xu, Ruo, Li, Shengjian, Paruchova, Jaroslava, McBriar, Mark D., Guzik, Henry, Palani, Anandan, Clader, John W., Cox, Kathleen, Greenlee, William J., Hawes, Brian E., Kowalski, Timothy J., O’Neill, Kim, Spar, Brian D., Weig, Blair, Weston, Daniel J.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2006 14(10):3285-3299
Autor:
Ruo Xu, Monica Vicarel, Lili Zhang, Duane A. Burnett, Giuseppe Terracina, Lynn A. Hyde, Wen-Lian Wu, Qi Zhang, Thomas Bara, William J. Greenlee, Robert A. Del Vecchio, Amin A. Nomeir, Mcbriar Mark D, Mary Cohen-Williams, Josien Hubert B, Murali Rajagopalan, Julie Lee, Theodros Asberom, Martin S. Domalski, John W. Clader, Chad Bennett, Lixin Song, Eric M. Parker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:844-849
An investigation is detailed of the structure activity relationships (SAR) of two sulfone side chains of compound (−)- 1a (SCH 900229), a potent, PS1-selective γ-secretase inhibitor and clinical candidate for the treatment of Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7acb8f10ab43bcf5cd40b91f4b39ca
https://doi.org/10.1016/j.bmcl.2012.11.047
https://doi.org/10.1016/j.bmcl.2012.11.047
Autor:
Hyde Lynn, Pissarnitski Dmitri, J Greenlee William, XU Ruo, McBRIAR Mark, Zhang LiLi, WU Wen-Lian, Bara Tom, LI HongMei, Clader John, Josien Hubert, Tang HaiQun, A Burnett Duane, Zhao ZhiQiang, Asberom Ted, Sasikumar Thavalakulamgara, Domalski Martin, Su Jing, McKITTRICK Brian, Rajagopalan Murali, Qiang Li, Bennett Chad, Cole David
Publikováno v:
Science China Chemistry. 54:1688-1701
Novel tricyclic sulfones as γ-secretase inhibitors have been reported by this laboratory for the treatment of Alzheimer’s disease. Compounds in this series have comparable or better in vitro activities and in vivo efficacies than sulfonamide analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e325e6cca0e6d70c9d979699edc638d5
https://doi.org/10.1007/s11426-011-4388-6
https://doi.org/10.1007/s11426-011-4388-6
Autor:
Wu, Wen-Lian, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Josien, Hubert, McBriar, Mark, Rajagopalan, Murali, Vicarel, Monica, Xu, Ruo, Hyde, Lynn A., Del Vecchio, Robert A., Cohen-Williams, Mary E., Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M., Zhang, Lili
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 February 2013 23(3):844-849
Autor:
Sasikumar Thavalakulamgar K, Andrew T. McPhail, Ruo Xu, Lynn A. Hyde, Ted Asberom, Wen-Lian Wu, Jing Su, Duane A. Burnett, Haiqun Tang, Josien Hubert B, Tom Bara, Lili Zhang, Hongmei Li, Martin S. Domalski, Li Qiang, Zhiqiang Zhao, Mckittrick Brian A, Dmitri A. Pissarnitski, William J. Greenlee, Murali Rajagopalan, Chad Bennett, David Cole, Mcbriar Mark D, John W. Clader
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
A novel series of tricyclic gamma-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4811174cbfc257679dcdd4619def41f9
https://pubmed.ncbi.nlm.nih.gov/20236824
https://pubmed.ncbi.nlm.nih.gov/20236824
Autor:
McBriar, Mark D., Clader, John W., Chu, Inhou, Del Vecchio, Robert A., Favreau, Leonard, Greenlee, William J., Hyde, Lynn A., Nomeir, Amin A., Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Zhang, Lili, Zhao, Zhiqiang
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2008 18(1):215-219
Autor:
Li, Hongmei, Asberom, Theodros, Bara, Thomas A., Clader, John W., Greenlee, William J., Josien, Hubert B., McBriar, Mark D., Nomeir, Amin, Pissarnitski, Dmitri A., Rajagopalan, Murali, Xu, Ruo, Zhao, Zhiqiang, Song, Lixin, Zhang, Lili
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2007 17(22):6290-6294
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Autor:
McBriar, Mark D., Guzik, Henry, Shapiro, Sherry, Xu, Ruo, Paruchova, Jaroslava, Clader, John W., O’Neill, Kim, Hawes, Brian, Sorota, Steve, Margulis, Michael, Tucker, Kristal, Weston, Daniel J., Cox, Kathleen
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2006 16(16):4262-4265