Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo.

Autor: McAvoy, Kathleen M.¹, Rajamohamed Sait, Hameetha¹, Marsh, Galina¹, Peterson, Michael¹, Reynolds, Taylor L.¹, Gagnon, Jake¹, Geisler, Sarah¹, Leach, Prescott¹, Roberts, Chris¹, Cahir-McFarland, Ellen¹, Ransohoff, Richard M.², Crotti, Andrea¹ andrea.crotti@astellas.com

Publikováno v: PLoS ONE. 8/13/2019, Vol. 14 Issue 8, p1-28. 28p.

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An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.

Autor: Vicidomini C; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Goode TD; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA., McAvoy KM; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Yu R; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA., Beveridge CH; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA., Iyer SN; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA., Victor MB; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Leary N; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Evans L; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Steinbaugh MJ; Harvard Chan Bioinformatics Core, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA., Lai ZW; Harvard Chan Advanced Multi-omics Platform, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Lyon MC; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Silvestre MRFS; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bonilla G; Department of Molecular Biology. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sadreyev RI; Department of Molecular Biology. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Walther TC; Harvard Chan Advanced Multi-omics Platform, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.; Howard Hughes Medical Institute, Boston, Massachusetts, USA., Sui SH; Harvard Chan Bioinformatics Core, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA., Saido T; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198 Japan., Yamamoto K; Graduate School of Technology, Industrial and Social Sciences, Tokushima University, 2-1 Minami-jyosanjima, Tokushima 770-8513, Japan., Murakami M; Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan., Tsai LH; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Chopra G; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.; Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN 47907, USA., Sahay A; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; BROAD Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 03. Date of Electronic Publication: 2024 Sep 03.