TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors.

Autor: McAvera RM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7BL, UK., Morgan JJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7BL, UK., Herrero AB; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.; Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain.; Cancer Research Center-IBMCC (USAL-CSIC), Salamanca, Spain., Mills KI; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7BL, UK., Crawford LJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7BL, UK. lisa.crawford@qub.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2024 Apr 16; Vol. 14 (1), pp. 8797. Date of Electronic Publication: 2024 Apr 16.

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.

Autor: Crawford LJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. lisa.crawford@qub.ac.uk., Campbell DC; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Morgan JJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Lawson MA; Department of Oncology and Metabolism, Sheffield Myeloma Research Team, Medical School, University of Sheffield, Sheffield, UK., Down JM; Department of Oncology and Metabolism, Sheffield Myeloma Research Team, Medical School, University of Sheffield, Sheffield, UK., Chauhan D; Department of Medical Oncology, The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., McAvera RM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Morris TC; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Hamilton C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Krishnan A; Cell Biology Unit, University Medical Center Mainz, Mainz, Germany., Rajalingam K; Cell Biology Unit, University Medical Center Mainz, Mainz, Germany., Chantry AD; Department of Oncology and Metabolism, Sheffield Myeloma Research Team, Medical School, University of Sheffield, Sheffield, UK., Irvine AE; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.

Publikováno v: Oncogene [Oncogene] 2020 Jul; Vol. 39 (27), pp. 5001-5014. Date of Electronic Publication: 2020 Jun 10.